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Showing 1–4 of 4 results
Advanced filters: Author: Fujiko Duke Clear advanced filters
  • This paper reports one of the largest breast cancer whole-exome and whole-genome sequencing efforts so far, identifying previously unknown recurrent mutations in CBFB, deletions of RUNX1 and recurrent MAGI1–AKT3 fusion; the fusion suggests that the use of ATP-competitive AKT inhibitors should be evaluated in clinical trials.

    • Shantanu Banerji
    • Kristian Cibulskis
    • Matthew Meyerson
    ResearchOpen Access
    Nature
    Volume: 486, P: 405-409
  • RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sensitivity to Aurora kinase inhibitors.

    • Athea Vichas
    • Amanda K. Riley
    • Alice H. Berger
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19
  • Whole-exome sequencing and analysis of 115 cervical carcinoma–normal paired samples, in addition to transcriptome and whole-genome sequencing for a subset of these tumours, reveal novel genes mutated at significant levels within this cohort and provide evidence that HPV integration is a common mechanism for target gene overexpression; results also compare mutational landscapes between squamous cell carcinomas and adenocarcinomas.

    • Akinyemi I. Ojesina
    • Lee Lichtenstein
    • Matthew Meyerson
    Research
    Nature
    Volume: 506, P: 371-375