Pyroptosis is a programmed cell death mechanism relevant in cancer therapy that can be triggered by endocytic organelle stress, but is challenging to induce in a controlled manner. In this paper the authors engineer a library of ultra-pH-sensitive nanophotosensitizers that can target specific endocytic organelles and elicit pyroptotic cancer cell death in a controlled fashion.
- Binlong Chen
- Yue Yan
- Yiguang Wang
