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Showing 1–6 of 6 results
Advanced filters: Author: Göran Widmalm Clear advanced filters

  • The cell wall of the oral bacterium Streptococcus mutans carries SCC, a rhamnose-containing polysaccharide with glucose side-chain decorations. Here, the authors report the SCC structure and the synthesis mechanism, revealing how four glucosyltransferases work together to synthesize the side-chains.

    • Jeffrey S. Rush
    • Svetlana Zamakhaeva
    • Natalia Korotkova
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The cell wall of the bacterial pathogen Group A Streptococcus is decorated with a polysaccharide termed GAC, which is a target for vaccine development. Here, Rush et al. characterize the linkage between GAC and peptidoglycan, and identify a protein that deacetylates the linkage and thus protects the pathogen against host cationic antimicrobial proteins.

    • Jeffrey S. Rush
    • Prakash Parajuli
    • Natalia Korotkova
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Lipopolysaccharides, important components of the bacterial cell envelope, are synthesized at the inner membrane by the Wzx/Wzy-dependent assembly pathway. A cryo-EM structure of an intact E. coli WzzB, the polysaccharide co-polymerase component of this pathway, reveals details of the transmembrane, cytoplasmic domains and a conserved a proline-rich segment proximal to the C-terminal transmembrane helix.

    • Benjamin Wiseman
    • Ram Gopal Nitharwal
    • Martin Högbom
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12