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The efficacy of CAR-T cells against solid tumors is still limited by immunosuppressive factors. Here, the authors show that engineering of CAR T cells with A1R enhances their efficacy against solid tumors in vitro and in vivo.

ILT J1101 is a white dwarf–M dwarf binary that emits minute-duration radio pulses with a 2-h periodicity. The period of the radio pulses is linked to the orbital period of the binary, rather than the rotation period of the stellar components.

This study uses multispecies modelling to show that the management of a coral predator, the crown-of-thorns starfish, could help corals recover following bleaching events. They show that management was most effective when heat stress severity for corals was low to moderate, when corals had lower heat sensitivity and when the recruitment rate of starfish was high.

Electron spins generated by phosphorus dopant atoms buried in silicon represent well-isolated quantum bits with long coherence times, but so far the control of such single electrons has been insufficient to use them in this way. These authors report single-shot, time-resolved readout of electron spins in silicon, achieved by coupling the donor atoms to a charge-sensing device called a single-electron transistor. This opens a path to the development of a new generation of quantum computing and spintronic devices in silicon.

Donors spins in silicon are coherent, high-performance qubits, but scale-up has been challenging. Here the authors present the first experimental demonstration of exchange-based, entangling two qubit gates between electrons bound to ³¹P donors in Si.

African Americans have an elevated risk of developing chronic kidney disease, yet only a fraction of those with high-risk genotypes develop the disease. Here, the authors show that a missense variant in APOL1 has a strong protective effect when co-inherited with the high-risk G2 allele of APOL1, with important implications for clinical practice and translational research.

Quantum computers will require a large network of coherent qubits, connected in a noise-resilient way. Tosi et al. present a design for a quantum processor based on electron-nuclear spins in silicon, with electrical control and coupling schemes that simplify qubit fabrication and operation.

The existence and properties of tetraquark states with two heavy quarks and two light antiquarks have been widely debated. Here, the authors use a unitarized model to study the properties of an exotic narrow state compatible with a doubly charmed tetraquark.

A combined analysis of datasets across four JWST instrument modes provides a benchmark transmission spectrum for the Saturn-mass WASP-39 b. The broad wavelength range and high resolution constrain orbital and stellar parameters to below 1%.

Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

Time-series observations from the JWST of the transiting exoplanet WASP-39b show gaseous water in the planet’s atmosphere and place an upper limit on the abundance of methane.

The LHCb collaboration reports an improved measurement of the oscillation frequency of mesons consisting of a bottom quark and strange quark, which is then combined with previous results.

The Large Hadron Collider beauty collaboration reports a test of lepton flavour universality in decays of bottom mesons into strange mesons and a charged lepton pair, finding evidence of a violation of this principle postulated in the standard model.

A broad-wavelength 0.5–5.5 µm atmospheric transmission spectrum of WASP-39b, a 1,200 K, roughly Saturn-mass, Jupiter-radius exoplanet, demonstrates JWST’s sensitivity to a rich diversity of exoplanet compositions and chemical processes.

The presence of multiple minima, or valleys, in the conduction band of group IV semiconductors can be a problem for spin-based quantum computing, but can also enable alternative qubit implementations. Yang et al. demonstrate electrostatic control of the valleys’ energy splitting in a silicon quantum dot.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

Transmission spectroscopy observations from the James Webb Space Telescope show the detection of carbon dioxide in the atmosphere of the gas giant exoplanet WASP-39b.

Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases.

The accurate determination of quark mixing parameters is essential for the understanding of the Standard Model. The LHCb collaboration now reports the coupling strength of the b quark to the u quark through the measurement of a baryonic decay mode.

CP violation has deep implications for particle physics and cosmology. Previously observed only in meson decays, signs of CP violation have now been spotted in baryon decays by analysing the proton–proton collision data from the LHCb detector.

The discovery of a long-period radio transient, GPM J1839–10, prompted a search of radio archives, thereby finding that this source has been repeating since at least 1988.

The LHCb Collaboration reports the observation of an exotic, narrow, tetraquark state that contains two charm quarks, an up antiquark and a down antiquark.

A hybrid approach to detecting individual defect spins in solids, whereby an optically induced spin change is detected electronically, offers the high fidelities required for quantum information processing devices.

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

The electron spin in a silicon-based quantum dot can be controlled electrically for as long as several tens of microseconds, which improves the prospects for quantum information processing based on this type of quantum dot.