Nature Search

Myocardial infarction accelerates atherosclerosis

Myocardial infarction accelerates atherosclerosis through activation of the sympathetic nervous system, and the consequent release of haematopoietic stem and progenitor cells.

Partha Dutta
Gabriel Courties
Matthias Nahrendorf
Research27 Jun 2012
Nature

Volume: 487, P: 325-329
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis

Maximilian J. Schloss
Maarten Hulsmans
Matthias Nahrendorf
Amendments and Corrections15 Jun 2022
Nature Immunology

Volume: 23, P: 1285
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis

Nahrendorf and colleagues show that B cells in the bone marrow are an important source of the neurotransmitter acetylcholine, which limits hematopoiesis through modulating the signals produced by the bone marrow stromal niche during steady-state and emergency hematopoiesis.

Maximilian J. Schloss
Maarten Hulsmans
Matthias Nahrendorf
Research28 Mar 2022
Nature Immunology

Volume: 23, P: 605-618
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

Sick heart and vessels skew hematopoiesis toward inflammatory myeloid cells. Rhode et al. show that hypertension, atherosclerosis and myocardial infarction cause endothelial dysfunction in bone marrow (BM), which in return causes overproduction of inflammatory myeloid cells and systemic leukocytosis in mice. This process is mediated by VEGF signaling, IL-6 and versican production by the BM endothelium.

David Rohde
Katrien Vandoorne
Matthias Nahrendorf
ResearchOpen Access23 Dec 2021
Nature Cardiovascular Research

Volume: 1, P: 28-44
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

Systemically injected lipid–polymer nanoparticles encapsulating small interfering RNA for silencing genes in bone-marrow endothelial cells of mice improved the healing of the mice after myocardial infarction.

Marvin Krohn-Grimberghe
Michael J. Mitchell
Matthias Nahrendorf
Research05 Oct 2020
Nature Biomedical Engineering

Volume: 4, P: 1076-1089
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

The beneficial effects of exercise on cardiovascular disease are linked to decreased inflammation through crosstalk between adipose tissue and hematopoietic progenitor cells in the bone marrow.

Vanessa Frodermann
David Rohde
Matthias Nahrendorf
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1761-1771
Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

The authors describe microscopic channels that directly connect the skull marrow cavities with the meninges. Neutrophils originating from the skull marrow have a higher propensity to travel to the ischemic mouse brain than cells in the tibia.

Fanny Herisson
Vanessa Frodermann
Matthias Nahrendorf
Research27 Aug 2018
Nature Neuroscience

Volume: 21, P: 1209-1217
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that are rapidly excreted by the kidney and with high affinity for macrophages in atherosclerotic plaques.

Edmund J. Keliher
Yu-Xiang Ye
Matthias Nahrendorf
ResearchOpen Access16 Jan 2017
Nature Communications

Volume: 8, P: 1-12
Therapeutic siRNA silencing in inflammatory monocytes in mice

In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al. now show that an optimized lipid nanoparticle delivers siRNA to inflammatory monocytes in mice and, when transporting CCR2 siRNA, has therapeutic effects in cardiovascular disease, cancer and transplant rejection.

Florian Leuschner
Partha Dutta
Matthias Nahrendorf
Research09 Oct 2011
Nature Biotechnology

Volume: 29, P: 1005-1010
Chronic variable stress activates hematopoietic stem cells

Activation of bone marrow hematopoietic stem cells by chronic stress raises circulating leukocyte levels and increases atherosclerotic plaque inflammation.

Timo Heidt
Hendrik B Sager
Matthias Nahrendorf
Research22 Jun 2014
Nature Medicine

Volume: 20, P: 754-758
Fluorescence microscopy tensor imaging representations for large-scale dataset analysis

Claudio Vinegoni
Paolo Fumene Feruglio
Ralph Weissleder
ResearchOpen Access27 Mar 2020
Scientific Reports

Volume: 10, P: 1-15

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