CDDP induces the stabilization of HIF-1α that leads to the expression of its target gene BNIP3. BNIP3 promotes autophagy of mitochondria by increasing their fission and degradation rates. This process ultimately boosts the ability of resistant cancer cells to escape CDDP cytotoxicity by eliminating one of its main targets, mitochondria, from which cytochrome c is released to initiate cell death. While BNIP3 expression could be a new prognostic factor to predict the chemotherapy responsiveness of cancer patients, targeting mitophagy could be a new therapeutic approach to overcome platinum resistance. We used BioRender Software (BioRender.com) to draw the schematic picture.
- Caterina Vianello
- Veronica Cocetta
- Monica Montopoli
