Nature Search

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Structural control over single-crystalline oxides for heterogeneous catalysis

Single-crystalline oxides offer well-defined surfaces, enabling superior control of their chemistry with tunable catalytic activity and enhanced stability. This review summarizes new advances in their synthesis and analysis, and their prominence in heterogeneous catalysis, namely thermo-, electro- and photocatalysis.

Seok-Jin Kim
Raghu V. Maligal-Ganesh
Cafer T. Yavuz
Reviews28 Apr 2025
Nature Reviews Chemistry

Volume: 9, P: 397-414
Author Correction: Telemedicine — maintaining quality during times of transition

Sue Romanick-Schmiedl
Ganesh Raghu
Amendments and Corrections07 Jul 2020
Nature Reviews Disease Primers

Volume: 6, P: 1
Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts

The association of telomere length with age and mortality across racially diverse pulmonary fibrosis populations is unknown. Here, the authors show that leukocyte telomere length associates with chronologic age and is predictive of mortality in pulmonary fibrosis across racial groups.

Ayodeji Adegunsoye
Chad A. Newton
Imre Noth
ResearchOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1-13
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

Roy et al. describe a generalized method for computationally designing miniproteins selective for a single integrin heterodimer and conformational state. The designed αvβ6 inhibitor remains monomeric and maintains biological activity following aerosolization and shows excellent efficacy in bleomycin induced lung fibrosis.

Anindya Roy
Lei Shi
David Baker
ResearchOpen Access13 Sept 2023
Nature Communications

Volume: 14, P: 1-18
Idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive lung scarring that is thought to occur in a genetically susceptible, ageing individual through aberrant reparative responses to repeated injury to the alveolar epithelium. This Primer summarizes the processes thought to underlie the development of IPF and clinical challenges faced in treating patients with this irreversible condition.

Fernando J. Martinez
Harold R. Collard
Athol U. Wells
Reviews20 Oct 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-19
Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes

Nancy Casanova
Tong Zhou
Joe G. N. Garcia
ResearchOpen Access15 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
Telemedicine — maintaining quality during times of transition

Here, the authors consider some limitations of telemedicine and offer a perspective on how clinicians can adapt to working in different health-care delivery systems.

Sue Romanick-Schmiedl
Ganesh Raghu
Comments & Opinion01 Jun 2020
Nature Reviews Disease Primers

Volume: 6, P: 1-2
Combination of esomeprazole and pirfenidone enhances antifibrotic efficacy in vitro and in a mouse model of TGFβ-induced lung fibrosis

Afshin Ebrahimpour
Manisha Ahir
Yohannes T. Ghebre
ResearchOpen Access30 Nov 2022
Scientific Reports

Volume: 12, P: 1-12
Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes

Suhas Ganesh
Alekhya Vemula
Meera Purushottam
ResearchOpen Access07 Dec 2022
Scientific Reports

Volume: 12, P: 1-11

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