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Global evolution of inflammatory bowel disease across epidemiologic stages

An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of inflammatory bowel disease, and models stage 4 progression.

Lindsay Hracs
Joseph W. Windsor
Gilaad G. Kaplan
ResearchOpen Access30 Apr 2025
Nature

Volume: 642, P: 458-466
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

How anti-helminth and allergic immune responses are initiated is poorly understood. Here the authors show that to trigger these responses, dendritic cells specifically require methyl-CpG-binding ___domain-2, a protein promoting repressed chromatin state.

Peter C. Cook
Heather Owen
Andrew S. MacDonald
ResearchOpen Access24 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Macrophages in intestinal homeostasis and inflammatory bowel disease

Macrophages are critical for maintaining intestinal homeostasis, yet are implicated in chronic intestinal inflammation. This Review provides detailed insights into the biology of macrophages in the context of inflammatory bowel disease and discusses future perspectives.

Lizi M. Hegarty
Gareth-Rhys Jones
Calum C. Bain
Reviews17 Apr 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 20, P: 538-553

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Global evolution of inflammatory bowel disease across epidemiologic stages

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

Macrophages in intestinal homeostasis and inflammatory bowel disease

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