The mechanism by which the tubular architecture of the endoplasmic reticulum (ER) is maintained is unclear, although homotypic membrane fusion is known to be required for ER biogenesis and maintenance and this is dependent on GTP hydrolysis. Here it is demonstrated that loss of the GTPase Atlastin in Drosophila causes ER fragmentation, whereas its overexpression induces enlargement of ER profiles.
- Genny Orso
- Diana Pendin
- Andrea Daga
