Nature Search

Nature-inspired methylated polyhydroxybutyrates from C1 and C4 feedstocks

Polyhydroxyalkanoates are potential substitutes for non-degradable polyolefin plastics. Now, it has been shown that structurally related methylated polyhydroxybutyrates, synthesized from carbon monoxide and 2-butenes, can provide a full suite of polyolefin-like polymers. These materials can be recycled or upcycled, and their properties can be easily tuned by varying the cis/trans ratio of the starting materials.

Zhiyao Zhou
Anne M. LaPointe
Geoffrey W. Coates
Research06 Apr 2023
Nature Chemistry

Volume: 15, P: 856-861
The mutagenic forces shaping the genomes of lung cancer in never smokers

An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

Marcos Díaz-Gay
Tongwu Zhang
Maria Teresa Landi
Research02 Jul 2025
Nature

P: 1-12
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing ___domain

Drugs that rescue function of episodic ataxia 1 (EA1) mutant potassium channels are lacking. Here, Manville et al identify and describe the molecular basis for Native American botanical ataxia remedies that directly rescue EA1 mutant channels.

Rían W. Manville
J. Alfredo Freites
Geoffrey W. Abbott
ResearchOpen Access06 Jun 2023
Nature Communications

Volume: 14, P: 1-18
Murine maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehaviour

Malnutrition during pregnancy has lasting effects on maternal and offspring health. Its adverse impacts are modified by the maternal microbiome and attenuated by gestational treatment with select microbial metabolites.

Elena J. Coley-O’Rourke
Gregory R. Lum
Elaine Y. Hsiao
Research13 Jun 2025
Nature Microbiology

Volume: 10, P: 1648-1664
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

T cell responses can be generated to either pathogen infection or from priming with a vaccine. Here the authors compare T cell generation, phenotype and single cell transcriptome of participants vaccinated with a mpox vaccine or infected with the virus showing that the virus induced T cells showed more effective function and phenotype.

Ji-Li Chen
Beibei Wang
Tao Dong
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-17
Resonant osmotic diodes for voltage-induced water filtration across composite membranes

While nanofluidics demonstrate unconventional properties at the nanoscale, large-scale implementation remains challenging. The authors demonstrate macroscale resonant electro-osmotic transport in asymmetric membranes for advanced water filtration applications.

Soufiane Abdelghani-Idrissi
Lucie Ries
Lydéric Bocquet
Research11 Jun 2025
Nature Materials

Volume: 24, P: 1109-1115
Ambient solar thermal catalysis for polyolefin upcycling using copper encapsulated in silicon nanosheets and chloroaluminate ionic liquid

Solution-based methods exist to upcycle waste polyolefins, although these resort to the use of co-reactants and require non-negligible energy inputs. Here the authors show how a solar thermal catalytic system based on copper particles encapsulated within a 2D Si material can strongly alleviate such issues.

Chuanwang Xing
Chengliang Mao
Wei Sun
Research05 Jun 2025
Nature Catalysis

Volume: 8, P: 556-568
A binary star model for SS433

D. S. De Young
Geoffrey Burbidge
Research01 Sept 1979
Nature

Volume: 281, P: 183-185
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Edmond M. Kwan
Sarah W. S. Ng
Alison Y. Zhang
Research27 May 2025
Nature Medicine

P: 1-15
Annexin-A1 deficiency uncovers female-specific pathways in blood pressure control and cardiovascular remodeling in mice

Annexin-A1 shields against hypertension-induced cardiovascular damage, with heightened effects in females. Estrogen-driven upregulation of annexin-A1 unveils a novel, sex-specific protective axis, offering innovative targets for tailored cardiovascular therapies.

Jaideep Singh
Kristy L. Jackson
Cheng Xue Qin
ResearchOpen Access06 Jul 2025
Communications Biology

Volume: 8, P: 1-16
Human mitochondrial ferritin exhibits highly unusual iron-O₂ chemistry distinct from that of cytosolic ferritins

Human mitochondrial ferritin protects against oxidative stress by detoxifying iron. Here, highly unusual iron-oxygen chemistry, involving formation of a mixed valent diiron site and a tyrosine radical, is uncovered.

Justin M. Bradley
Zinnia Bugg
Nick E. Le Brun
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-10
CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma

Pathological B-cell receptor (BCR) signaling is a key driver of mantle cell lymphoma tumorigenesis. Here, the authors discover that CEACAM1, an immunoglobulin-like transmembrane protein, is essential for a subset of mantle cell lymphoma through activation of the BCR.

Serene Xavier
Vivian Nguyen
Vu N. Ngo
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-18
Histochemical Demonstration of Cholinesterase and 5-Nucleotidase in Normal and Diseased Human Muscle

EVELYN B. BECKETT
GEOFFREY H. BOURNE
Research13 Apr 1957
Nature

Volume: 179, P: 771-772
Exploring the potential of dental calculus to shed light on past human migrations in Oceania

Preservation of oral microbiome ancient DNA from Oceania is much better than human ancient DNA. The authors leverage this to demonstrate that oral microbial community composition in Oceania is not only distinct from the rest of the world, but it may also be associated with patterns of ancient human migration in the region.

Irina M. Velsko
Zandra Fagernäs
Christina Warinner
ResearchOpen Access24 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Intra-Cellular Distribution of Vitamin C in the Adrenal Cortex

GEOFFREY H. BOURNE
Research30 Sept 1950
Nature

Volume: 166, P: 549-550
Increasing burden of poor mental health attributable to high temperature in Australia

The authors assess the current and future burden of mental and behavioural disorders across Australia. They show that high temperatures contributed 1.8% of Australia’s mental and behavioural disorder burden in the 2010s with expected increases to 2.4–2.8% by the 2050s and highlight the need for both adaptation and mitigation.

Jingwen Liu
Blesson M. Varghese
Peng Bi
Research14 Apr 2025
Nature Climate Change

Volume: 15, P: 489-496
Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

Katelyn E. Connelly
Katherine Hullin
Laufey T. Amundadottir
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-18
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytosine, leading to the derepression of transposable elements and, in certain cases, the activation of nearby genes.

Hugo Sepulveda
Xiang Li
Anjana Rao
Research28 Mar 2025
Nature Structural & Molecular Biology

P: 1-15
Alkaline Phosphatase in Taste Buds and Nasal Mucosa

GEOFFREY H. BOURNE
Research20 Mar 1948
Nature

Volume: 161, P: 445-446
A Template Model for the Synthesis of Ribonucleic Acid from Deoxyribonucleic Acid

GEOFFREY ZUBAY
Research08 Nov 1958
Nature

Volume: 182, P: 1290-1292
FEEDING POST-WAR EUROPE

GEOFFREY BOURNE
Research14 Feb 1942
Nature

Volume: 149, P: 182-184
Hippocampal output suppresses orbitofrontal cortex schema cell formation

Inactivation of the ventral subiculum does not change existing schema cells in the orbitofrontal cortex (OFC) but aids their formation during new learning. This challenges the idea that the OFC relies on the hippocampus and suggests that these regions work in parallel to process different aspects of cognitive maps.

Wenhui Zong
Jingfeng Zhou
Geoffrey Schoenbaum
ResearchOpen Access14 Apr 2025
Nature Neuroscience

Volume: 28, P: 1048-1060
Respiratory risks from wildfire-specific PM_2.5 across multiple countries and territories

Wildfires are becoming increasingly frequent in several regions around the world due to climate change, posing serious health risks, especially for respiratory diseases. This study examines the respiratory health risk and burden of wildfire-specific PM_2.5 pollution across eight countries and territories.

Yiwen Zhang
Rongbin Xu
Shanshan Li
ResearchOpen Access08 Apr 2025
Nature Sustainability

Volume: 8, P: 474-484
The Perineural Epithelium: Nature and Significance

T. R. SHANTHAVEERAPPA
GEOFFREY H. BOURNE
Research10 Aug 1963
Nature

Volume: 199, P: 577-579
A versatile and open source design for one and two photon light sheet microscopy

Antoine Hubert
Thomas Panier
Volker Bormuth
ResearchOpen Access03 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Histochemical Changes in Kidneys and Adrenals of Rats made Hypertensive by the Goldblatt Method

ANTONIO PASQUALINO
GEOFFREY H. BOURNE
Research22 Nov 1958
Nature

Volume: 182, P: 1426-1427
Histochemistry of Xanthine Oxidase

GEOFFREY H. BOURNE
Research01 Aug 1953
Nature

Volume: 172, P: 193-195
Modeling seawater intrusion along the Alabama coastline using physical and machine learning models to evaluate the effects of multiscale natural and anthropogenic stresses

Hossein Gholizadeh
T. Prabhakar Clement
Yong Zhang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-18
Heterogeneity of Deoxyribonucleic Acids

GEOFFREY L. BROWN
M. WATSON
Research22 Aug 1953
Nature

Volume: 172, P: 339-342
A family of structural genes for human lymphoblastoid (leukocyte-type) interferon

Geoffrey Allen
Karl H. Fantes
Research02 Oct 1980
Nature

Volume: 287, P: 408-411
Neural Basis of Motivation Lateralizes with Motor Control

Geoffrey Brookshire
Daniel Casasanto
ResearchOpen Access09 Nov 2011
Nature Precedings

P: 1
Fault related folding near the Wind River thrust, Wyoming, USA

Geoffrey King
Jonathan Brewer
Research10 Nov 1983
Nature

Volume: 306, P: 147-150
Nageotte nodules in human dorsal root ganglia reveal neurodegeneration in diabetic peripheral neuropathy

Nageotte nodules in the dorsal root ganglia were first described 100 years ago, but little is known about them. Here, the authors link Nageotte nodules to neurodegeneration in diabetic neuropathy in humans and describe their molecular composition.

Stephanie I. Shiers
Khadijah Mazhar
Theodore J. Price
ResearchOpen Access05 May 2025
Nature Communications

Volume: 16, P: 1-16
Biological Action of Aldosterone in vitro

GEOFFREY W. G. SHARP
ALEXANDER LEAF
Research20 Jun 1964
Nature

Volume: 202, P: 1185-1188
Aeronautics before 1919

GEOFFREY TAYLOR
Research22 Oct 1971
Nature

Volume: 233, P: 527-529
POTATO EYES AS READILY TRANSPORTABLE 'SEED' FOR THE COLONIES

GEOFFREY EVANS
Research23 Oct 1943
Nature

Volume: 152, P: 464-466
“International Relations as a University Discipline”

GEOFFREY L. GOODWIN
Research24 May 1952
Nature

Volume: 169, P: 890
Large language models for scientific discovery in molecular property prediction

Zheng et al. developed LLM4SD, a framework using large language models to predict molecular properties. The method leverages the ability of large language models to synthesize knowledge from literature and to reason about scientific data with ___domain expertise.

Yizhen Zheng
Huan Yee Koh
Shirui Pan
Research25 Feb 2025
Nature Machine Intelligence

Volume: 7, P: 437-447
Mutations in the human retinal degeneration slow (RDS) gene can cause either retinitis pigmentosa or macular dystrophy

John Wells
John Wroblewski
Alan Bird
Research01 Mar 1993
Nature Genetics

Volume: 3, P: 213-218
The origin of large local uplift in extensional regions

Geoffrey King
Michael Ellis
Research27 Dec 1990
Nature

Volume: 348, P: 689-693
The photochemistry of methane and carbon monoxide in the troposphere in 1950 and 1985

Joel S. Levine
Curtis P. Rinsland
Geoffrey M. Tennille
Research21 Nov 1985
Nature

Volume: 318, P: 254-257
Integrated human genome–wide maps constructed using the CEPH reference panel

Kenneth H. Buetow
James L. Weber
Jeffrey C. Murray
Research01 Apr 1994
Nature Genetics

Volume: 6, P: 391-393
Osteopontin attenuates the foreign-body response to silicone implants

Transcriptomic and proteomic analyses show that high levels of the extracellular-matrix protein osteopontin are associated with the attenuated foreign-body response elicited by breast silicone implants wrapped with acellular dermal matrix.

Michelle F. Griffin
Jennifer B. Parker
Michael T. Longaker
Research24 Mar 2025
Nature Biomedical Engineering

P: 1-22
Digital technology and service tradability: evidence from patent innovations and knowledge utilization

LEI WANG
Yihan Chen
Geoffrey Hewings
ResearchOpen Access01 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-18
CREB3 gain of function variants protect against ALS

Cross-species transcriptomics on vulnerable neuronal populations unravels the transcription factor CREB3 and its regulatory network as resilience markers of ALS. Genetics and epidemiology further identify the protective rare variant CREB3R119G.

Salim Megat
Christine Marques
Caroline Rouaux
ResearchOpen Access26 Mar 2025
Nature Communications

Volume: 16, P: 1-17
The safety and effectiveness of optometrist-delivered selective laser trabeculoplasty

Alexander Geoffrey Swystun
Elizabeth Langton
Pouya Alaghband
Research20 May 2025
Eye

P: 1-5
MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration

Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Hui San Chin
Jinming Cheng
Nai Yang Fu
ResearchOpen Access22 Mar 2025
Nature Communications

Volume: 16, P: 1-20
Systematic approach to the correction of intonation in wind instruments

Richard A. Smith
Geoffrey J. Daniell
Research26 Aug 1976
Nature

Volume: 262, P: 761-765
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

Simon J. Powis
Edward V. Deverson
Jonathan C. Howard
Research21 May 1992
Nature

Volume: 357, P: 211-215

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