Nature Search

A thalamo-amygdalar circuit underlying the extinction of remote fear memories

Silva et al. reveal distinct circuits for the extinction of remote fear memories, with the thalamic nucleus reuniens and its outputs to the basolateral amygdala taking center stage.

Bianca A. Silva
Simone Astori
Johannes Gräff
Research20 May 2021
Nature Neuroscience

Volume: 24, P: 964-974
In mouse chronic pancreatitis CD25⁺FOXP3⁺ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

The function of T regulatory cells in the tissue fibrosis in chronic pancreatitis is not fully understood. Here the authors use a mouse model of chronic pancreatitis to show that Treg cells reduce IL-4 mediated chronic inflammation in the pancreas associated with M2-like macrophages in vivo.

Juliane Glaubitz
Anika Wilden
Matthias Sendler
ResearchOpen Access03 Aug 2022
Nature Communications

Volume: 13, P: 1-20
The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

Philipp Schwabl
Ksenia Brusilovskaya
Thomas Reiberger
ResearchOpen Access19 Jun 2018
Scientific Reports

Volume: 8, P: 1-13
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Microdeletions of chromosome 16p11.2 can cause autism, but the pathogenic mechanisms remain unclear. Here the authors show that in a 16p11.2 mouse model, mGluR5 synaptic plasticity and protein synthesis are altered and that a modulator of mGluR5 reverses the cognitive deficits.

Di Tian
Laura J Stoppel
Mark F Bear
Research12 Jan 2015
Nature Neuroscience

Volume: 18, P: 182-184
Citizen science illuminates the nature of city lights

This study employs a citizen science approach to identify and classify over 230,000 light sources in German city centers, suburbs and villages. The results underscore the pivotal role of citizen science in expanding knowledge of artificial light emissions and bolstering policymaking efforts to mitigate urban light pollution.

Team Nachtlichter
Achim Tegeler
Yiğit Öner Altıntaş
ResearchOpen Access16 Jun 2025
Nature Cities

Volume: 2, P: 496-505
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.

Dominik Saul
Robyn Laura Kosinsky
Sundeep Khosla
ResearchOpen Access16 Aug 2022
Nature Communications

Volume: 13, P: 1-15
Progressively smaller glacier lake outburst floods despite worldwide growth in lake area

By quantifying changes in lake area before glacier lake outburst floods (GLOFs) worldwide from 1990 to 2023, this study shows that despite the overall growth in total lake area and hazard potential, pre-GLOF lake areas barely changed or even decreased regionally and are dependent on a decreasing number of ice-dammed lakes.

Georg Veh
Björn G. Wang
Oliver Korup
ResearchOpen Access18 Feb 2025
Nature Water

Volume: 3, P: 271-283
Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Brain tissue from patients with focal cortical dysplasia type II (FCDII) exhibits dysmorphic neurons bearing hallmarks of senescence. Treatment with a senolytic drug reduces seizures in an FCDII preclinical mouse model.

Théo Ribierre
Alexandre Bacq
Stéphanie Baulac
ResearchOpen Access06 May 2024
Nature Neuroscience

Volume: 27, P: 1125-1136
mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex

Elyza Kelly
Samantha M Schaeffer
Mustafa Sahin
Research05 Dec 2017
Neuropsychopharmacology

Volume: 43, P: 1457-1465
Less extreme and earlier outbursts of ice-dammed lakes since 1900

An assessment of ice-dam failures in six mountain regions shows that extreme peak flows and volumes have declined sharply since 1900, and that ice-dam floods today originate at higher elevations and earlier in the year.

Georg Veh
Natalie Lützow
Oliver Korup
ResearchOpen Access15 Feb 2023
Nature

Volume: 614, P: 701-707
Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss

Xianyi Meng
Zhen Lin
Aline Bozec
ResearchOpen Access17 Feb 2022
Bone Research

Volume: 10, P: 1-12
Underestimated mass loss from lake-terminating glaciers in the greater Himalaya

Accounting for subaqueous melting from lake-terminating glaciers increases estimated glacier mass loss across the Himalaya by 7% over the past 20 years, according to analysis of satellite observations and bathymetric measurements.

Guoqing Zhang
Tobias Bolch
Weicai Wang
Research03 Apr 2023
Nature Geoscience

Volume: 16, P: 333-338
Binge Alcohol Drinking by Mice Requires Intact Group1 Metabotropic Glutamate Receptor Signaling Within the Central Nucleus of the Amygdale

Debra K Cozzoli
Justin Courson
Karen K Szumlinski
Research21 Aug 2013
Neuropsychopharmacology

Volume: 39, P: 435-444
Mechanisms of Disease: Toll-like receptors in cardiovascular disease

Toll-like receptors are the primary innate immune receptors and could, therefore, be a key link between cardiovascular disease development and the immune system. Here, Stefan Frantz, Georg Ertl and Johann Bauersachs review this exciting field of research, and explore the evidence supporting a role for toll-like receptors in the pathophysiology of cardiovascular diseases.

Stefan Frantz
Georg Ertl
Johann Bauersachs
Reviews01 Aug 2007
Nature Clinical Practice Cardiovascular Medicine

Volume: 4, P: 444-454
Characteristics and changes of glacial lakes and outburst floods

Warmer temperatures enhance formation of glacial lakes that can suddenly and catastrophically release as a glacial lake outburst flood (GLOF), threatening downstream lives and infrastructure. This Review outlines observed and projected changes in glacial lakes and GLOFs, reporting that both will increase with ongoing deglaciation.

Guoqing Zhang
Jonathan L. Carrivick
Natalie Lützow
Reviews21 May 2024
Nature Reviews Earth & Environment

Volume: 5, P: 447-462
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation

Xianyi Meng
Sahar Asadi-Asadabad
Aline Bozec
ResearchOpen Access14 Nov 2024
Cellular & Molecular Immunology

Volume: 22, P: 54-67
Unchanged frequency of moraine-dammed glacial lake outburst floods in the Himalaya

Melting glaciers are increasing Himalayan glacial lakes and potentially the risk of outburst floods. An advanced automated algorithm identifies glacial lake outburst floods from Landsat images since the late 1980s to improve understanding of these events and trends in their frequency.

Georg Veh
Oliver Korup
Ariane Walz
Research18 Mar 2019
Nature Climate Change

Volume: 9, P: 379-383
Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa

S Kirschnek
J Vier
G Häcker
Research10 Jun 2011
Cell Death & Differentiation

Volume: 18, P: 1805-1814

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