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Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Juan Jose Rodriguez-Sevilla
Irene Ganan-Gomez
Simona Colla
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation

Analysis of whole-genome sequencing data from hematopoietic stem and progenitor cells taken from patients with myeloma shows how treatment shapes clonal architecture and sheds light on the evolution of treatment-related myeloid neoplasms.

Hidetaka Uryu
Koichi Saeki
Koichi Takahashi
ResearchOpen Access01 Jul 2025
Nature Genetics

P: 1-13
Allogeneic hematopoietic cell transplantation for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN)

Qaiser Bashir
Denái R. Milton
Naveen Pemmaraju
Research11 Oct 2021
Bone Marrow Transplantation

Volume: 57, P: 51-56
Donor clonal hematopoiesis increases risk of acute graft versus host disease after matched sibling transplantation

Betül Oran
Richard E. Champlin
Koichi Takahashi
Research16 Jun 2021
Leukemia

Volume: 36, P: 257-262
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia

Notch1 is frequently activated promoting T-cell acute lymphoblastic leukaemia (T-ALL). Here, the authors show that Notch1 induces oxidative phosphorylation dependency in T-ALL and synergism when inhibiting both mitochondrial complex I and glutaminolysis in preclinical murine and human xenograft models.

Natalia Baran
Alessia Lodi
Marina Konopleva
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-20
Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy derived from the precursors of plasmacytoid dendritic cells. Here the authors characterize the anti-tumor activity of allogeneic anti-CD123 CAR-T cells in preclinical models of BPDCN.

Tianyu Cai
Agnès Gouble
Marina Konopleva
ResearchOpen Access28 Apr 2022
Nature Communications

Volume: 13, P: 1-11
Correction to: Donor clonal hematopoiesis increases risk of acute graft versus host disease after matched sibling transplantation

Betül Oran
Richard E. Champlin
Koichi Takahashi
Amendments and Corrections07 Dec 2021
Leukemia

Volume: 36, P: 298
Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

The response rate of relapsed/refractory acute myeloid leukemia patients to PD-1 checkpoint blockade is low and unpredictable. Authors here show by single cell RNA sequencing, T cell receptor profiling and genomic analysis that the phenotypes and repertoire of CD8 + T cells and loss of chromosome 7/7q are important determinants of response.

Hussein A. Abbas
Dapeng Hao
Andrew Futreal
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-13
An inhibitor of oxidative phosphorylation exploits cancer vulnerability

A new inhibitor targeting the mitochondrial complex I shows antitumor activity in preclinical models of acute myeloid leukemia and glioblastoma relying on oxidative phosphorylation.

Jennifer R. Molina
Yuting Sun
Joseph R. Marszalek
Research11 Jun 2018
Nature Medicine

Volume: 24, P: 1036-1046
Impact of a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), on allogeneic transplant outcomes in patients with acute myeloid leukemia and myelodysplastic syndrome

Piyanuch Kongtim
Simrit Parmar
Stefan O. Ciurea
Research26 Sept 2018
Bone Marrow Transplantation

Volume: 54, P: 839-848

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Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes

Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation

Allogeneic hematopoietic cell transplantation for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN)

Donor clonal hematopoiesis increases risk of acute graft versus host disease after matched sibling transplantation

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia

Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

Correction to: Donor clonal hematopoiesis increases risk of acute graft versus host disease after matched sibling transplantation

Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Impact of a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), on allogeneic transplant outcomes in patients with acute myeloid leukemia and myelodysplastic syndrome

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