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Showing 1–5 of 5 results

Advanced filters: Author: Gintautas Vainorius Clear advanced filters

Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths

Expression of transcription factors can convert one cell type to another beyond developmental paths. Here, the authors show that cells can take two mechanistically distinct paths in the same transition paradigm when driven by the similar proneural factors Ascl1 and Ngn2.

Gintautas Vainorius
Maria Novatchkova
Ulrich Elling
ResearchOpen Access02 Sept 2023
Nature Communications

Volume: 14, P: 1-14
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models

Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.

Esther C. H. Uijttewaal
Joonsun Lee
Ulrich Elling
ResearchOpen Access16 Dec 2024
Nature Biotechnology

P: 1-13
ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers

Yelagandula et al. show that ZFP462 interacts with G9A/GLP to modulate enhancers with binding sites for embryonic stem cell-specific transcription factors, thereby regulating lineage specification during neural differentiation of mouse embryonic stem cells.

Ramesh Yelagandula
Karin Stecher
Oliver Bell
Research05 Jan 2023
Nature Cell Biology

Volume: 25, P: 42-55
Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles

Guide RNA selection plays an essential role in CRISPR screens, the Vienna Bioactivity CRISPR (VBC) scoring system provides an improved selection for sgRNAs that generate loss-of-function alleles.

Georg Michlits
Julian Jude
Ulrich Elling
Research08 Jun 2020
Nature Methods

Volume: 17, P: 708-716
CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens

Combining each sgRNA with a unique molecular identifier in a genome-wide screen increases sensitivity and robustness in both positive and negative selection.

Georg Michlits
Maria Hubmann
Ulrich Elling
Research16 Oct 2017
Nature Methods

Volume: 14, P: 1191-1197