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Showing 1–50 of 291 results

Advanced filters: Author: Goo Lee Clear advanced filters

Modulating light level patterns reduces rest/activity disruption associated with shiftwork

Varun Mandi
Haley Miller
Mariana G. Figueiro
ResearchOpen Access03 Jul 2025
npj Biological Timing and Sleep

Volume: 2, P: 1-9
Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications

Lack of standardization between biofoundries limits their operational efficiency. In this perspective the authors advocate for a common framework to improve interoperability and reproducibility.

Haseong Kim
Nathan J. Hillson
Seung-Goo Lee
ReviewsOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-6
SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling

Mi Kyoung Seo
Jung Goo Lee
Sung Woo Park
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Activation of the β1 isozyme of phospholipase C by α subunits of the G_q class of G proteins

Stephen J. Taylor
Ho Zoon Chae
John H. Exton
Research11 Apr 1991
Nature

Volume: 350, P: 516-518
Risk of pancreatic cancer according to glycemic status in nonalcoholic fatty liver disease: a nationwide cohort study

Han Na Jung
Ji Hye Huh
Sung-Hee Ihm
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Outcome of second allogeneic hematopoietic cell transplantation in adult patients with relapsed B-cell acute lymphoblastic leukemia in the era of new immunotherapeutic agents

Daehun Kwag
Jae-Ho Yoon
Seok Lee
Research17 Jun 2025
Bone Marrow Transplantation

P: 1-9
Multi-platform discovery of haplotype-resolved structural variation in human genomes

Structural variants (SVs) in human genomes contribute diversity and diseases. Here, the authors use a multi-platform strategy to generate haplotype-resolved SVs for three human parent–child trios.

Mark J. P. Chaisson
Ashley D. Sanders
Charles Lee
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-16
Discovery of effectors for casein kinase signaling in the African trypanosome

Justin Wiedeman
Gaurav Kumar
Kojo Mensa-Wilmot
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-20
7SL RNA and signal recognition particle orchestrate a global cellular response to acute thermal stress

7SL is traditionally thought to function within the SRP to aid in protein translocation into the ER. Here, the authors show that under acute heat shock, it selectively arrests cellular transcription and translation, independent of the signal peptide.

Bojan Bujisic
Hun-Goo Lee
Jeannie T. Lee
ResearchOpen Access14 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome

While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations. Here the authors identify EPHA2 as another causative gene of Pendred syndrome with SLC26A4.

Mengnan Li
Shin-ya Nishio
Masanori Nakayama
ResearchOpen Access12 Mar 2020
Nature Communications

Volume: 11, P: 1-15
Diagnosis of early-stage bladder cancer via unprocessed urine samples at the point of care

A point-of-care diagnostic device for the detection of early-stage bladder in urine obviates the need of sample pretreatment and enhances diagnostic accuracy.

Changjoon Keum
Haejin Yeom
Youngdo Jeong
Research28 Nov 2024
Nature Biomedical Engineering

P: 1-13
Rare variant contribution to the heritability of coronary artery disease

Whole genome sequences enable discovery of rare variants which may help to explain the heritability of common diseases. Here the authors find that ultra-rare variants explain ~50% of coronary artery disease (CAD) heritability and highlight several functional processes including cell type-specific regulatory mechanisms as key drivers of CAD genetic risk.

Ghislain Rocheleau
Shoa L. Clarke
Ron Do
ResearchOpen Access09 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Research on the extrusion characteristics for the geometry of materials in material extrusion process using heating syringe

Kwang Yeol Yu
Do Young Goo
In Hwan Lee
ResearchOpen Access02 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

Ki-Hoan Nam
Jae-Hoon Choi
Goo Taeg Oh
ResearchOpen Access01 Aug 2006
Experimental & Molecular Medicine

Volume: 38, P: 445-452
ATP released from β‐amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion

Soo Yoon Kim
Ju Hyun Moon
Yong Beom Lee
ResearchOpen Access01 Dec 2007
Experimental & Molecular Medicine

Volume: 39, P: 820-827
Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo

Keun Woo Park
Hwan Goo Lee
Yong Beom Lee
ResearchOpen Access01 Dec 2007
Experimental & Molecular Medicine

Volume: 39, P: 812-819
Flexible, scalable, high channel count stereo-electrode for recording in the human brain

Electrodes available for deep brain recording and stimulation have a number of limitations. Here the authors describe a thin-film depth electrode that may offer improved spatial and temporal resolution for recording brain activity.

Keundong Lee
Angelique C. Paulk
Shadi. A. Dayeh
ResearchOpen Access17 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Medication versus globus pallidus internus deep brain stimulation in Parkinson’s disease with deep learning video analysis of finger tapping

Grace Yoojin Lee
Hee Yeon Kwon
Sun Ju Chung
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-15
F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patients

Yunyoung Jung
Hongil Ha
Byung-Il Yeh
ResearchOpen Access01 Mar 2001
Experimental & Molecular Medicine

Volume: 33, P: 29-31
Correction: Corrigendum: The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice

Mi-Ran Lee
Chae-ji Lim
Goo Taeg Oh
Amendments and Corrections21 Jan 2015
Nature Communications

Volume: 6, P: 1-2
Preoperative smoking and robot-assisted radical cystectomy outcomes & complications in multicenter KORARC database

Joongwon Choi
Jooyoung Lee
Yong Seong Lee
ResearchOpen Access08 May 2024
Scientific Reports

Volume: 14, P: 1-7
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression

Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 (APAF1), support DNA packaging on the surface of tumor-derived extracellular vesicles that are taken up by resident liver macrophages, thereby suppressing metastasis.

Inbal Wortzel
Yura Seo
David Lyden
Research03 Dec 2024
Nature Cancer

Volume: 5, P: 1815-1833
Ultrafast coherent motion and helix rearrangement of homodimeric hemoglobin visualized with femtosecond X-ray solution scattering

Femtosecond time-resolved X-ray solution scattering (fs-TRXSS) measurements provide information on the structural dynamics of proteins in solution. Here, the authors present a structure refinement method for the analysis of fs-TRXSS data and use it to characterise the ultrafast structural changes of homodimeric haemoglobin.

Yunbeom Lee
Jong Goo Kim
Hyotcherl Ihee
ResearchOpen Access16 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro

Jun-Woo Kim
Keon-Wook Kang
Youngmi Kim Pak
ResearchOpen Access01 May 2002
Experimental & Molecular Medicine

Volume: 34, P: 137-144
Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism

Michung Yoon
Sunhyo Jeong
Goo Taeg Oh
ResearchOpen Access01 Dec 2002
Experimental & Molecular Medicine

Volume: 34, P: 481-488
Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia

Identifying the mechanisms underlying the early inflammatory phase of aortic valve disease is crucial for disease prevention. Here the authors perform single-cell RNA sequencing to show the immunomodulatory role of PPARγ in valvular endothelial cells during hyperlipidemia.

Seung Hyun Lee
Nayoung Kim
Jae-Hoon Choi
ResearchOpen Access17 Sept 2022
Nature Communications

Volume: 13, P: 1-22
The Single Chain Properties of the Bisphenol A Polycarbonate by the Rotational-Isomeric-State Monte Carlo Method

Sukmin Lee
Jung Goo Lee
Hosull Lee
Research01 Sept 2001
Polymer Journal

Volume: 33, P: 685-689
The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice

Retnla is an adipokine with known roles in tissue repair and inflammation. Here Lee et al. show that Retnla also promotes cholesterol metabolism and excretion, thereby lowering blood cholesterol levels and reducing the development of atherosclerosis in mice.

Mi-Ran Lee
Chae-ji Lim
Goo Taeg Oh
Research15 Jul 2014
Nature Communications

Volume: 5, P: 1-15
FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics

FICTURE is a segmentation-free approach for identifying tissue architecture in spatial transcriptomics data. FICTURE is compatible with both imaging-based and sequencing-based methods and is uniquely suited for handling the largest available datasets.

Yichen Si
ChangHee Lee
Hyun Min Kang
Research12 Sept 2024
Nature Methods

Volume: 21, P: 1843-1854
Author Correction: Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts

Sung-Jin Bae
Min Wook Shin
Kyu-Won Kim
Amendments and CorrectionsOpen Access04 Jun 2025
Experimental & Molecular Medicine

Volume: 57, P: 1339-1340
Comparison of the trabecular meshwork length between open and closed angle with evaluation of the scleral spur ___location

Wungrak Choi
Min woo Lee
Gong Je Seong
ResearchOpen Access02 May 2019
Scientific Reports

Volume: 9, P: 1-8
Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover

Aeby et al. report that DCP1A negatively regulates Tsix RNA abundance by suppressing its transcriptional elongation and RNA stability, thus contributing to X-chromosome inactivation.

Eric Aeby
Hun-Goo Lee
Jeannie T. Lee
Research17 Aug 2020
Nature Cell Biology

Volume: 22, P: 1116-1129
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

Mutations in SHANK2 have been associated with autism spectrum disorders in humans; here, Shank2 mutant mice are shown to exhibit autistic-like behaviours that can be improved by restoring decreased NMDA receptor function.

Hyejung Won
Hye-Ryeon Lee
Eunjoon Kim
Research13 Jun 2012
Nature

Volume: 486, P: 261-265
AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis

Direct targeting of oncogenic KRAS activity is a challenge. Here the authors report that a splice variant of AIMP2, AIMP2-DX2, enhances KRAS stability by blocking ubiquitin-mediated degradation of KRAS via the E3 ligase, Smurf2, and identify a chemical that can hinder AIMP2-DX2 from interacting with KRAS.

Dae Gyu Kim
Yongseok Choi
Sunghoon Kim
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-17
Isoalantolactone induces the apoptosis of oxaliplatin-resistant human colorectal cancer cells mediated by ROS generation and activation of JNK and p38 MAPK

Seung-On Lee
Sang Hoon Joo
Jung-Hyun Shim
ResearchOpen Access28 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Structural dynamics of protein-protein association involved in the light-induced transition of Avena sativa LOV2 protein

Here, the authors provide mechanistic insight into light-induced dimerization of a Light-Oxygen-Voltage (LOV) ___domain using time-resolved X-ray liquidography, furthering our understanding LOV ___domain photoactivation and protein-protein interaction-driven oligomerization.

Changin Kim
So Ri Yun
Hyotcherl Ihee
ResearchOpen Access14 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin

The classical neuronal-gene corepressor RCOR1/CoREST is paradoxically enriched in transcriptionally active chromatin. Here the authors show RCOR1 is recruited during promoter-proximal pausing and negatively regulates the nascent-transcript synthesis. They also show that an RCOR1-LSD1- HDAC1 complex removes lysine acetylation from RNA polymerase II to repress transcription.

Carlos Rivera
Hun-Goo Lee
María Estela Andrés
ResearchOpen Access23 Mar 2022
Nature Communications

Volume: 13, P: 1-15
Determining the charge distribution and the direction of bond cleavage with femtosecond anisotropic x-ray liquidography

Tracking the flow of charge in reacting molecules may provide key insight into reaction mechanisms, but is particularly challenging in liquid solutions. Here the authors, by analyzing the isotropic and anisotropic scattering signal in femtosecond time resolved X-ray liquidography, determine the charge localization and structural changes during photodissociation of the triiodide anion I₃^-

Jun Heo
Jong Goo Kim
Hyotcherl Ihee
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-11
Tailoring gadolinium-doped ceria-based solid oxide fuel cells to achieve 2 W cm⁻² at 550 °C

In low-temperature solid oxide fuel cells, power losses due to large ohmic resistances and activation barriers of ion transport are a common problem. Here, Lee et al. report a gadolinium-doped ceria-based solid oxide fuel cell, which overcomes the problem and achieves a power density of 2 W cm⁻².

Jin Goo Lee
Jeong Ho Park
Yong Gun Shul
Research04 Jun 2014
Nature Communications

Volume: 5, P: 1-10
Single-cell transcriptome profiling of the stepwise progression of head and neck cancer

Head and neck squamous cell carcinomas (HNSCCs) undergo a stepwise progression from normal tissues. In order to better understand the molecular mechanisms behind such progression, here the authors profile HNSCC tumors at different stages using single-cell RNA-seq, and observe the role of interactions with the tumor microenvironment.

Ji-Hye Choi
Bok-Soon Lee
Chul-Ho Kim
ResearchOpen Access24 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Photosensitive ion channels in layered MXene membranes modified with plasmonic gold nanostars and cellulose nanofibers

Artificial ion channels are in demand for ionotronic devices. Here, the authors use layered MXene membranes modified with plasmonic gold nanostars and cellulose nanofibers to convert a thermal gradient into an ion current for photosensitive ion channeling.

Jeonghee Yeom
Ayoung Choe
Hyunhyub Ko
ResearchOpen Access23 Jan 2023
Nature Communications

Volume: 14, P: 1-11
Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation

In-Hyuk Jung
You-Han Lee
Goo Taeg Oh
ResearchOpen Access27 Jan 2012
Experimental & Molecular Medicine

Volume: 44, P: 311-318
Effect of intraoperative fluid volume on postoperative ileus after robot-assisted radical cystectomy

Ji Sung Shim
Tae Il Noh
Seok Ho Kang
ResearchOpen Access18 May 2021
Scientific Reports

Volume: 11, P: 1-9
Coordinated change of a ratio of methylated H3-Iysine 4 or acetylated H3 to acetylated H4 and DNA methylation is associated with tissue-specific gene expression in cloned pig

Jae-Ku Kang
Kwang-Wook Park
Jeung-Whan Han
ResearchOpen Access01 Feb 2007
Experimental & Molecular Medicine

Volume: 39, P: 84-96
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II

Min Hee Choi
In Kyung Lee
Sang Won Kang
Research19 May 2005
Nature

Volume: 435, P: 347-353
Comparison between norepinephrine plus epinephrine and norepinephrine plus vasopressin after return of spontaneous circulation in patients with out-of-hospital cardiac arrest

Sejoong Ahn
Bo-Yeong Jin
Ji Hoon Kim
ResearchOpen Access18 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Excessive NLRP3 inflammasome activation underlies inflammatory diseases such as gout. Here the authors show that orphan nuclear receptor small heterodimer partner protein (SHP) negatively regulates NLRP3, and its loss leads to accumulation of damaged mitochondria and gout-like immunopathology.

Chul-Su Yang
Jwa-Jin Kim
Eun-Kyeong Jo
ResearchOpen Access06 Feb 2015
Nature Communications

Volume: 6, P: 1-11
Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts

Mouse fibroblasts can be simultaneously directly reprogrammed into cardiomyocytes, endothelial cells and smooth muscle cells to form cardiac tissue structures that improve cardiac function on implantation into infarcted mouse hearts.

Jaeyeaon Cho
Sangsung Kim
Young-sup Yoon
Research23 Aug 2021
Nature Biomedical Engineering

Volume: 5, P: 880-896
Correction: Corrigendum: The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens

Soon Ho Hong
Jin Sik Kim
Jae Jong Kim
Amendments and Corrections01 Dec 2004
Nature Biotechnology

Volume: 22, P: 1589

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