Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Gracjan Michlewski Clear advanced filters

  • hnRNP A1 is an auxiliary factor that promotes the Microprocessor-mediated processing of pri-mir-18a, of the oncomiR-1 cluster. Here the authors employ an integrative structural biology approach and provide insights into the molecular mechanism of how hnRNP A1 facilitates pri-mir-18a biogenesis.

    • Hamed Kooshapur
    • Nila Roy Choudhury
    • Michael Sattler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • The RNA-binding ubiquitin E3 ligase TRIM25 plays a critical role in antiviral immunity. Here the authors identify key RNA-binding residues of TRIM25, link RNA binding to antiviral activity, reveal RNA structural and sequence preferences, and investigate binding to the viral genome.

    • Lucía Álvarez
    • Kevin Haubrich
    • Janosch Hennig
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • microRNAs regulate gene expression and control cell fate and differentiation processes. In this work, Nowak et al. reveal that brain-specific miR-9 is under post-transcriptional control and that the pre-miR-9 binding protein Lin28a decreases the levels of mature miR-9 during retinoic acid-mediated neuronal differentiation.

    • Jakub S. Nowak
    • Nila Roy Choudhury
    • Gracjan Michlewski
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12

  • The Drosha–DGCR8, or Microprocessor, complex, is required for microRNA biogenesis. DGCR8 recognizes the RNA substrates, whereas Drosha functions as an endonuclease. High-throughput sequencing and cross-linking immunoprecipitation (HITS-CLIP) analyses reveal many other RNA targets of DGCR8 besides microRNAs, including snoRNAs, which are processed in a Drosha-independent manner, as well as long noncoding RNAs and mRNAs of protein-coding genes.

    • Sara Macias
    • Mireya Plass
    • Javier F Cáceres
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 760-766

  • let-7a, a miRNA involved in differentiation, was known to be regulated by Lin-28. Now work reveals another factor that could control let-7a levels in vivo: hnRNP A1 binds to unprocessed pri-let-7a and inhibits its processing by Drosha. The inhibitory effect of hnRNP A1 is further shown to occur via antagonizing the binding of KSRP to pri-let-7a, which is known to promote biogenesis.

    • Gracjan Michlewski
    • Javier F Cáceres
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1011-1018