Nature Search

Induction of ornithine decarboxylase by IL-3 is mediated by sequential c-Myc-independent and c-Myc-dependent pathways

Graham Packham
John L Cleveland
Research04 Sept 1997
Oncogene

Volume: 15, P: 1219-1232
Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1

Christine M Eischen
Graham Packham
John L Cleveland
Research01 Nov 2001
Oncogene

Volume: 20, P: 6983-6993
Fas activates NF-κB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-α

Graham Packham
Jill M Lahti
John L Cleveland
Research01 Feb 1997
Cell Death & Differentiation

Volume: 4, P: 130-139
The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock

Mark J Coldwell
Matthew L deSchoolmeester
Anne E Willis
Research11 Jul 2001
Oncogene

Volume: 20, P: 4095-4100
Correction: Chronic lymphocytic leukaemia

Thomas J. Kipps
Freda K. Stevenson
Kanti Rai
Amendments and Corrections09 Feb 2017
Nature Reviews Disease Primers

Volume: 3, P: 1
Correction: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Jessica Okosun
Rachel L Wolfson
Jude Fitzgibbon
Amendments and Corrections27 May 2016
Nature Genetics

Volume: 48, P: 700
The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription

Ramsey I Cutress
Paul A Townsend
Graham Packham
Research06 Aug 2003
Oncogene

Volume: 22, P: 4973-4982
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Identification of a novel human BCL-X promoter and exon

Lucy MacCarthy-Morrogh
Lynn Wood
Graham Packham
Research16 Nov 2000
Oncogene

Volume: 19, P: 5534-5538
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Mutation in myosin heavy chain 6 causes atrial septal defect

Yung-Hao Ching
Tushar K Ghosh
J David Brook
Research27 Feb 2005
Nature Genetics

Volume: 37, P: 423-428
Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage

Jorg Michels
Jason W O'Neill
Graham Packham
Research03 May 2004
Oncogene

Volume: 23, P: 4818-4827
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells

John M Draus
Mary Jane Elliott
Kelly M McMasters
ResearchOpen Access01 Dec 2001
Experimental & Molecular Medicine

Volume: 33, P: 209-219
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

Matthew Brimmell
Rezzeline Mendiola
Graham Packham
Research23 Apr 1998
Oncogene

Volume: 16, P: 1803-1812
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

Whole-genome sequencing of chronic lymphocytic leukemia from 485 patients identifies putative coding and noncoding drivers of disease. Genomically defined subgroups show distinct clinical and biological characteristics.

Pauline Robbe
Kate E. Ridout
Anna Schuh
ResearchOpen Access04 Nov 2022
Nature Genetics

Volume: 54, P: 1675-1689
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Jessica Okosun, David Sabatini and colleagues identify recurrent RRAGC mutations in follicular lymphoma, resulting in activated mTORC1 signaling. The activating nature of the mutations, their existence within the dominant clone and their stability during disease progression support the potential of these mutations as promising candidates for targeted therapy.

Jessica Okosun
Rachel L Wolfson
Jude Fitzgibbon
Research21 Dec 2015
Nature Genetics

Volume: 48, P: 183-188
DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

Beatriz Valle-Argos
Giorgia Chiodin
Freda K. Stevenson
ResearchOpen Access03 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

Lindsay D. Smith
Annabel R. Minton
Andrew J. Steele
ResearchOpen Access28 Aug 2019
Leukemia

Volume: 34, P: 640-644
DNA binding of USF is required for specific E-box dependent gene activation in vivo

Astrid Kiermaier
Jonathan M Gawn
Graham Packham
Research08 Dec 1999
Oncogene

Volume: 18, P: 7200-7211
Correction: Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter’s syndrome: therapeutic implications

Francesca Arruga
Valeria Bracciamà
Silvia Deaglio
Amendments and Corrections13 Dec 2019
Leukemia

Volume: 34, P: 1721
Chronic lymphocytic leukaemia

Research on the biology of chronic lymphocytic leukaemia (CLL) — a malignancy of CD5⁺ B cells — has profoundly enhanced the identification of patients who are at high risk of disease progression and the treatment of patients with drugs that target the distinctive features of CLL. This Primer highlights these advances, as well as the epidemiology, genetics and immunobiology of CLL.

Thomas J. Kipps
Freda K. Stevenson
Kanti Rai
Reviews19 Jan 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-22
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Dean Bryant
Lindsay Smith
Jonathan C. Strefford
ResearchOpen Access11 May 2023
Leukemia

Volume: 37, P: 1454-1463
Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter’s syndrome: therapeutic implications

Francesca Arruga
Valeria Bracciamà
Silvia Deaglio
Research29 Aug 2019
Leukemia

Volume: 34, P: 462-477
Data from a pre-publication independent replication initiative examining ten moral judgement effects

Warren Tierney
Martin Schweinsberg
Eric Luis Uhlmann
ResearchOpen Access11 Oct 2016
Scientific Data

Volume: 3, P: 1-7

Search

Induction of ornithine decarboxylase by IL-3 is mediated by sequential c-Myc-independent and c-Myc-dependent pathways

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1

Fas activates NF-κB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-α

The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock

Correction: Chronic lymphocytic leukaemia

Correction: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Identification of a novel human BCL-X promoter and exon

Mapping the human genetic architecture of COVID-19

Mutation in myosin heavy chain 6 causes atrial septal defect

Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage

A second update on mapping the human genetic architecture of COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells

Genetic mechanisms of critical illness in COVID-19

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

DNA binding of USF is required for specific E-box dependent gene activation in vivo

Correction: Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter’s syndrome: therapeutic implications

Chronic lymphocytic leukaemia

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter’s syndrome: therapeutic implications

Data from a pre-publication independent replication initiative examining ten moral judgement effects

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