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Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

Guangsheng Pei
Jimin Min
Anirban Maitra
Research23 Apr 2025
Nature

Volume: 642, P: 212-221
An atlas of epithelial cell states and plasticity in lung adenocarcinoma

Analyses of single epithelial cells from early-stage lung adenocarcinoma and normal lung identifies a population of intermediate cells that may have an increased likelihood of transforming to tumour cells after injury such as tobacco exposure.

Guangchun Han
Ansam Sinjab
Humam Kadara
ResearchOpen Access28 Feb 2024
Nature

Volume: 627, P: 656-663
Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma

Guangchun Han
Ansam Sinjab
Humam Kadara
Amendments and CorrectionsOpen Access18 Mar 2024
Nature

Volume: 628, P: E1
Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial

In patients with advanced clear cell renal cell carcinoma (ccRCC), sitravatinib (tyrosine kinase inhibitor) has shown efficacy both alone and in combination with nivolumab (anti-PD-1). Here, the authors investigate triplet combination of sitravatinib with nivolumab and ipilimumab (anti-CTLA4) in patients with metastatic ccRCC and longitudinal single-cell transcriptomic analysis.

Pavlos Msaouel
Kai Yu
Jianjun Gao
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-18
9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy

The molecular mechanisms of resistance to immune checkpoint therapy remain elusive. Here, the authors perform immunogenomic analysis of TCGA data and data from clinical trials for antiPD-1/PD-L1 therapy and highlight the association of 9p21 loss with a cold tumor microenvironment and resistance to therapy.

Guangchun Han
Guoliang Yang
Linghua Wang
ResearchOpen Access23 Sept 2021
Nature Communications

Volume: 12, P: 1-19
METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics

Integrating tissue histology with spatial transcriptomics (ST) can significantly enhance the analysis of tumor heterogeneity and the tumor microenvironment (TME). Here, the authors present METI, a computational framework to analyze cancer cells and the complex TME by integrating ST with histology imaging.

Jiahui Jiang
Yunhe Liu
Linghua Wang
ResearchOpen Access25 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas

Single-cell transcriptomics reveals that the heterogeneity of anti-CD19 CAR T cell infusion products contributes to variability in clinical response, early molecular response and development of immune effector cell-associated neurotoxicity syndrome in patients with large B cell lymphomas.

Qing Deng
Guangchun Han
Michael R. Green
Research05 Oct 2020
Nature Medicine

Volume: 26, P: 1878-1887
Author Correction: Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Shaojun Zhang
Vivian Changying Jiang
Michael Wang
Amendments and CorrectionsOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1
MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response when comparing to MTAP-proficient UC patients.

Omar Alhalabi
Jianfeng Chen
Jianjun Gao
ResearchOpen Access04 Apr 2022
Nature Communications

Volume: 13, P: 1-12
Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

Treatment with neoadjuvant BRAF/MEK-targeted therapy results in higher rates of major pathological response in female compared with male patients with melanoma, and pharmacological inhibition of androgen receptor signalling improved the responses of male and female mice to BRAF/MEK-targeted therapy.

Christopher P. Vellano
Michael G. White
Jennifer A. Wargo
Research15 Jun 2022
Nature

Volume: 606, P: 797-803
Author Correction: Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

Christopher P. Vellano
Michael G. White
Jennifer A. Wargo
Amendments and Corrections10 Jan 2023
Nature

Volume: 613, P: E3
Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Mantle cell lymphoma can be refractory to treatment. Here, the authors used single cell sequencing to study the tumours of patients that were responsive and resistant to treatment and find gains of 17q in resistant tumours, which they attribute to increased expression of Birc5 and validate these findings in mouse models of the disease.

Shaojun Zhang
Vivian Changying Jiang
Michael Wang
ResearchOpen Access17 May 2021
Nature Communications

Volume: 12, P: 1-17
Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma

Single-cell analysis of gastric cancer samples tracks the cell of origin of metastatic lesions and identifies an independent prognostic signature of the clinical outcome.

Ruiping Wang
Minghao Dang
Linghua Wang
Research04 Jan 2021
Nature Medicine

Volume: 27, P: 141-151
B cells and tertiary lymphoid structures promote immunotherapy response

Multiomic profiling of several cohorts of patients treated with immune checkpoint blockade highlights the presence and potential role of B cells and tertiary lymphoid structures in promoting therapy response.

Beth A. Helmink
Sangeetha M. Reddy
Jennifer A. Wargo
Research15 Jan 2020
Nature

Volume: 577, P: 549-555
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance

A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.

Yanshuo Chu
Enyu Dai
Linghua Wang
Research29 May 2023
Nature Medicine

Volume: 29, P: 1550-1562
Biochemical basis of synergism between pathogenic fungus Metarhizium anisopliae and insecticide chlorantraniliprole in Locusta migratoria (Meyen)

Miao Jia
Guangchun Cao
Zehua Zhang
ResearchOpen Access22 Jun 2016
Scientific Reports

Volume: 6, P: 1-15
Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

Hang Ma
Yingying Guo
Jianwei Zhu
ResearchOpen Access15 Feb 2022
Cell Discovery

Volume: 8, P: 1-14

Search

Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma

Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial

9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy

METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics

Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas

Author Correction: Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

Author Correction: Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma

B cells and tertiary lymphoid structures promote immunotherapy response

Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance

Biochemical basis of synergism between pathogenic fungus Metarhizium anisopliae and insecticide chlorantraniliprole in Locusta migratoria (Meyen)

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

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