The Gabija system is a newly discovered bacterial immune system. Here, the authors report the EM structure of the Gabija complex at 3.6 Å. Here, the authors show that when invading phages depletes cellular NTP and dNTP, the nuclease activity of Gabija complex is activated and cleaves the circular DNA to prevent phage DNA replication.
- Yanwu Huo
- Lingfei Kong
- Taotao Wei
