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Enantioenriched α-arylated dialkyl ketones with acidic proton are ubiquitous subunits in organic molecules and serve as synthetic precursors for other value-added chiral blocks. Here, the authors report a synthetic strategy of enantioenriched α-arylated dialkyl ketones enabled by nickel-catalyzed iterative cross-hydrocarbonylation of two alkenes.

Transition-metal-catalyzed asymmetric multicomponent reactions with two similar substrates often suffer from the lack of strategies to control the chemo-, regio-, and stereoselectivity. Here, the authors report a Cu(I)-catalyzed asymmetric radical 1,2-carboalkynylation of two different terminal alkynes and alkyl halides with chemo-, regio-, and stereoselectivity.

Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to differentiate into mature neurons.

Tungsten ditelluride has been recently discovered to possess very large and unsaturated magnetoresistance, which opens interesting perspectives for potential applications. Here the authors show suppression of the magnetoresistance and emergence of superconductivity at high pressure.

Direct and site-selective C–H functionalization of alkenes under environmentally benign conditions represents a useful and attractive yet challenging transformation to access value-added molecules. Here, the authors report a protocol for a variety of intermolecular Heck-type functionalization of C(sp2)–H bond of alkenes by thianthrenation.

High-entropy alloy catalysts hold promise for overcoming linear scaling relationships due to their structural complexity. Herein, the authors report a surface entropy reduction method that enables the exsolution of few-atom-layer metals on high-entropy alloy catalysts, resulting in enhanced electrocatalytic reduction of nitrate to ammonia with a Faradaic efficiency of 92.7%.

TET3 is essential to postnatal development due to unknown reasons. Here Mulet et al. demonstrate that TET3 is required for ATP synthase assembly in differentiated cells and that its loss leads to an unphysiological metabolic profile.

Transparent wood has potential in building applications, and there is interest in this having additional functionality. Here, the authors report the development of transparent wood with room temperature phosphorescence.

During meiosis, chromosomes undergo dramatic changes in morphology and intranuclear positioning. Here the authors mapped the 3D genome architecture throughout mouse spermatogenesis by Hi-C of sorted cells to reveal the contributions of transcriptional activity and mechanical force in modulating homolog alignment and recombination.

Neuroligins are extensively studied in neurons, but their role in glial cells remain unclear. Here the authors show that astrocytic deletion of neuroligin 3 impairs social memory, astrocyte activity, glutamate homeostasis, and synaptic plasticity.

Frustrated kagome magnets host both fermionic and bosonic excitations, but evidence of their interplay has been elusive. Here, the authors report a pronounced renormalization of electron bands near the Fermi surface due to the coupling with a flat phonon band in a kagome paramagnet, CoSn.

Gel electrolytes are promising for solid-state supercapacitors, due to their favourable properties such as high ion migration rate, mechanical strength, and water retention. Here, the authors report on a zwitterionic gel electrolyte giving robust performance in graphene-based solid-state supercapacitors.

The development of a transgene-free, rapid and controllable method for producing eight-cell-like cells from human pluripotent stem cells provides a valuable resource to study early human embryogenesis.

An automated deep-learning pipeline for chest-X-ray-image standardization, lesion visualization and disease diagnosis can identify viral pneumonia caused by COVID-19, assess its severity, and discriminate it from other types of pneumonia.

In this work, authors demonstrate highly stretchable conductive porous elastomers that can achieve up to 1200% strain with low or negative Poisson’s ratios by uniaxial, biaxial, and triaxial hot-pressing strategies.

N⁶-methyladenosine RNA and its reader YTHDC1 serve as a bridge to silencing retrotransposons through the RNA derived from these retrotransposons in mouse ES cells.

Efficient oxygen activation is crucial for catalytic oxidation reaction, but highly depends on the construction of active sites. Here, dual adjacent Fe atoms anchored on MnO₂ can assemble into a diatomic site, which activates molecular oxygen to form an active intermediate species Fe(O = O)Fe for CO oxidation.

Embryonic diapause is a state of dormancy with poorly understood mechanisms of embryo intrinsic regulation. Here, the authors show that murine diapause is a dynamic process, where tissue-scale reorganization of the pluripotent lineage is controlled in an autocrine manner by the Wnt/b-catenin/Esrrb signalling cascade.

Telomeres attach to the nuclear envelope to facilitate homolog pairing during meiosis prophase I. Here, the authors show that SUN1 and SPDYA interact, and demonstrate that this interaction is important for telomere structure and function, and essential to mice gametogenesis.

The unexpected phenomenon of rapid, long-distance transport of an ultrathin and uniform metal film on two-dimensional crystals is reported at temperatures well below the melting points of all of the materials involved. The effect is generalizable and may offer possibilities in confined space chemistry, as well as in two-dimensional crystal growth and devices.

High levels of TFIID, a basal transcription factor, are found to be essential to induce and maintain the transcriptional program of pluripotent cells.

The four transcription factors Oct4, Sox2, Klf4 and c-myc induce somatic cells to reprogramme to an early embryonic stem cell state. When expressed in somatic cells under culture conditions that are normally used for stem cells derived from mouse epiblast tissue of post-implantation embryos (EpiSCs), these factors drive reprogramming to a state that closely resembles EpiSCs, highlighting the importance of culture environment in determining the outcome of reprogramming.

It is detailed that adult mouse neural stem cells (NSCs) express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4or c-Myc are sufficient to generate iPS cells from NSCs. The number of reprogramming factors can be reduced when using somatic cells that endogenously express appropriate levels of complementing factors.

Qu et al. present a detailed three-dimensional spatial transcriptome atlas of all major organs in the mouse embryo at E13.5, providing a better understanding of organ development and cellular interactions during mammalian development.

The emission maximum of phosphorescence is normally larger than that of fluorescence. Here, authors report up-converted room-temperature phosphorescence materials that emit from higher-lying triplet states with 3n-π* characters and large phosphorescence decay rate constants, violating Kasha’s rule.

Voltage-gated sodium (Nav) channels are targeted by various clinically applied and investigational drugs. Here cryo-EM structures of Nav1.7 bound to 7 compounds with diverse chemical skeletons reveal the structural basis of action of these drugs and provide a 3D structural map for drug binding sites on Nav channels.

The mammalian transcription factors Oct4 and Pou2 are implicated in germ cell pluripotency induction and maintenance. Tapia and colleagues find that axolotl Pou2 and Oct4 reprogram mouse and human fibroblasts to a pluripotent state, suggesting ancestral Oct4 and Pou2 gene function is evolutionarily conserved.

A chemical screen targeting major epigenetic pathways identifies permissive epigenetic states that enable reprogramming with a broad range of transcriptional regulators and almost all octamer-binding (OCT) family members.

Yue, Zong, Li, Li, Zhang, Wu et al. introduce an in toto live-imaging system to track cardiac ventricle chamber formation at single-cell resolution for up to 1.5 days and digitally reconstruct cell dynamics.

Scanning tunnelling microscopy is used to reveal a new topological kagome magnet with an intrinsic Chern quantum phase, which shows a distinct Landau fan structure with a large Chern gap.