Nature Search

Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials

SARS-CoV-2 evolves into new subtypes necessitating further vaccine development. Here the authors generate a trivalent vaccine with Receptor Binding Domains from Delta, BA.5 and XBB.1.5 variants and characterize immunogenicity and protection in mice and safety in a phase I vaccine trial in humans.

Jingyun Yang
Weiqi Hong
Xiawei Wei
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-18
A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights

Cervical cancer remains a significant public health problem in many regions. Here, the authors perform a proteogenomic analysis of cervical cancer in Chinese patients; they reveal proteomic subgroups associated with clinical and biological features, and a potential biomarker of response to radiotherapy.

Jing Yu
Xiuqi Gui
Daming Gao
ResearchOpen Access22 Nov 2024
Nature Communications

Volume: 15, P: 1-23
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

A recombinant vaccine that targets the receptor-binding ___domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Jingyun Yang
Wei Wang
Xiawei Wei
Research29 Jul 2020
Nature

Volume: 586, P: 572-577
Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore

A copper(II)-functionalized Mycobacterium smegmatis porin A nanopore enables direct identification of all 20 proteinogenic amino acids, one unnatural amino acid and two post-translational modifications, and shows potential for peptide discrimination and sequencing.

Ming Zhang
Chao Tang
Jia Geng
ResearchOpen Access05 Mar 2024
Nature Methods

Volume: 21, P: 609-618
Cationic crosslinked carbon dots-adjuvanted intranasal vaccine induces protective immunity against Omicron-included SARS-CoV-2 variants

Lei et al. show that intranasal immunisation with their vaccine candidate is able to broadly protect mice from SARS-CoV-2 infection, including Omicron variants.

Hong Lei
Aqu Alu
Xiawei Wei
ResearchOpen Access09 May 2023
Nature Communications

Volume: 14, P: 1-17
A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.

Cai He
Jingyun Yang
Xiawei Wei
ResearchOpen Access17 Sept 2022
Nature Communications

Volume: 13, P: 1-14
Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion

Herpesvirus glycoprotein D binds to nectin 1 and the herpes virus entry mediator protein on the surface of host cells. In this study, Zhanget al. report the crystal structure of glycoprotein D in complex with the immunoglobulin-like domains of nectin 1, which suggests that binding of glycoprotein D to nectin 1 prevents nectin 1 dimerization.

Na Zhang
Jinghua Yan
George F Gao
Research06 Dec 2011
Nature Communications

Volume: 2, P: 1-10
Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4

Measles virus hemagglutinin (MVH) can bind to different cell surface receptors in the human host. CD46, the first identified MVH receptor, is used mainly by vaccine strains, whereas clinical strains can use SLAM on macrophages and dendritic cells and nectin-4 on epithelial cells. The crystal structure of MVH in complex with the outermost ectodomain of nectin-4 is now presented, revealing a potential target site for drug development.

Xiaoai Zhang
Guangwen Lu
George F Gao
Research02 Dec 2012
Nature Structural & Molecular Biology

Volume: 20, P: 67-72
Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Jingyun Yang
Wei Wang
Xiawei Wei
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E23
Active DNA unwinding and transport by a membrane-adapted helicase nanopore

Active translocation of DNA through nanopores usually needs enzyme assistance. Here authors present a nanopore derived from helicase E1 of bovine papillomavirus (BPV) which acts as a conductive pore embedded in lipid membrane to allow the translocation of ssDNA and unwinding of dsDNA.

Ke Sun
Changjian Zhao
Jia Geng
ResearchOpen Access08 Nov 2019
Nature Communications

Volume: 10, P: 1-11
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

The role of neutrophils in the regulation of tumour growth and metastasis remains controversial. Here, the authors demonstrate that neutrophils, by exerting inhibitory effects on cytotoxic NK cells, show a net pro-metastatic effect in immune-competent mice, while they are tumoricidal and anti-metastatic in NK cell-deficient hosts.

Peishan Li
Ming Lu
Guangwen Ren
ResearchOpen Access01 Sept 2020
Nature Communications

Volume: 11, P: 1-14
Stress corrosion cracking behavior of 20MnTiB high-strength bolts in simulation of humid climate in Chongqing

Lin Chen
Juan Wen
Chengwu Ming
ResearchOpen Access13 Dec 2021
Scientific Reports

Volume: 11, P: 1-9
A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants

Jingyun Yang
Weiqi Hong
Xiawei Wei
ResearchOpen Access26 Feb 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-15
Structural basis of BAM-mediated outer membrane β-barrel protein assembly

The structural basis of the late-stage intermediate assembly of outer membrane β-barrel proteins mediated by the bacterial β-barrel assembly machinery is determined.

Chongrong Shen
Shenghai Chang
Haohao Dong
Research26 Apr 2023
Nature

Volume: 617, P: 185-193
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis

Phagocytes can acquire lipids and this modulates their function in a variety of disease states, such as atherosclerosis. Ren and colleagues demonstrate that neutrophils accumulate lipids and deliver them to tumor cells, which supports their proliferation, survival and metastasis.

Peishan Li
Ming Lu
Guangwen Ren
Research21 Sept 2020
Nature Immunology

Volume: 21, P: 1444-1455
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Host tropism and cell entry of pathogenic coronaviruses are mediated by their envelope spike (S) proteins. Here the authors present structural analyses of trimeric MERS-CoV and SARS-CoV S proteins in pre-fusion conformation, and reveal two states of the receptor binding ___domain that suggest new avenues for the generation of neutralizing antibodies.

Yuan Yuan
Duanfang Cao
George F. Gao
ResearchOpen Access10 Apr 2017
Nature Communications

Volume: 8, P: 1-9
Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

CesT is a type III secretion system chaperone that interacts with the post-transcriptional regulator CsrA, which is important for the modulation of post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. Here the authors present the structure of the CsrA/CesT complex and propose a mechanism for CsrA-modulation by CesT.

Fei Ye
Fanli Yang
Guangwen Lu
ResearchOpen Access22 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants

Hong Lei
Weiqi Hong
Xiawei Wei
ResearchOpen Access20 Nov 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-13
Molecular Characterization of the Monoclonal Antibodies Composing ZMAb: A Protective Cocktail Against Ebola Virus

Jonathan Audet
Gary Wong
Xiangguo Qiu
ResearchOpen Access06 Nov 2014
Scientific Reports

Volume: 4, P: 1-8
Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis

De-Ke Jiang
Xiao-Pin Ma
Long Yu
ResearchOpen Access05 Nov 2015
Scientific Reports

Volume: 5, P: 1-7
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

MERS-CoV is a newly emerged coronavirus that is related to SARS-CoV and has proven fatal in half of the people it has infected to date: here the crystal structure of the MERS-CoV receptor binding ___domain is presented in complex with its receptor on human cells, CD26.

Guangwen Lu
Yawei Hu
George F. Gao
Research07 Jul 2013
Nature

Volume: 500, P: 227-231
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

Tokhir Dadaev
Edward J. Saunders
Zsofia Kote-Jarai
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-19
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

Long Yu and colleagues report a genome-wide association study for hepatitis B virus–related hepatocellular carcinoma (HBV-HCC). They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC.

De-Ke Jiang
Jielin Sun
Long Yu
Research16 Dec 2012
Nature Genetics

Volume: 45, P: 72-75
Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages

Jingyun Yang
Xuemei He
Yuquan Wei
ResearchOpen Access27 Jan 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-11
Three-dimensional stability of a fill slope reinforced by a frame beam anchor plate

Anping Huang
Yanpeng Zhu
Guangwen Fang
ResearchOpen Access24 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE

Wen Qiao
Chongrong Shen
Haohao Dong
ResearchOpen Access27 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-12
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind Eeles and colleagues present a genome-wide association study for prostate cancer. They report seven loci newly associated with prostate cancer susceptibility.

Rosalind A Eeles
Zsofia Kote-Jarai
Douglas F Easton
Research20 Sept 2009
Nature Genetics

Volume: 41, P: 1116-1121
Adenovirus-mediated interferon-β gene therapy suppresses growth and metastasis of human prostate cancer in nude mice

Guangwen Cao
Jingdong Su
Zhongyun Dong
Research10 Aug 2001
Cancer Gene Therapy

Volume: 8, P: 497-505
Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Weiqi Hong
Jingyun Yang
Xiawei Wei
ResearchOpen Access10 Mar 2022
Cellular & Molecular Immunology

Volume: 19, P: 577-587
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection

Jingyun Yang
Weiqi Hong
Xiawei Wei
ResearchOpen Access19 Jun 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-12
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding

Sheng Lin
Zimin Chen
Guangwen Lu
ResearchOpen Access21 Feb 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-3
Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response

Cai He
Xuemei He
Xiawei Wei
ResearchOpen Access09 Apr 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-4
Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2

Hong Lei
Aqu Alu
Xiawei Wei
ResearchOpen Access11 Dec 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-3
Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design

Sheng Lin
Hua Chen
Guangwen Lu
ResearchOpen Access29 Jul 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-4
Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

Hong Lei
Aqu Alu
Xiawei Wei
ResearchOpen Access17 May 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
Amendments and CorrectionsOpen Access17 Jan 2019
Nature Communications

Volume: 10, P: 1-5
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

Fei Ye
Xi Lin
Guangwen Lu
ResearchOpen Access16 Sept 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-12
Si-CSP9 regulates the integument and moulting process of larvae in the red imported fire ant, Solenopsis invicta

Daifeng Cheng
Yongyue Lu
Xiaofang He
ResearchOpen Access18 Mar 2015
Scientific Reports

Volume: 5, P: 1-14
A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding ___domain of the spike protein

Yan Li
Yuhua Wan
Jinghua Yan
Research22 Sept 2015
Cell Research

Volume: 25, P: 1237-1249
Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation

Mei-Mei Xiao
Yu-Qi Zhang
Ceng Luo
ResearchOpen Access17 Nov 2016
Scientific Reports

Volume: 6, P: 1-17
Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

Liyan Guo
Sheng Lin
Guangwen Lu
ReviewsOpen Access10 May 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-22

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