Nature Search

Calprotectin and iron match up

Iron availability plays a decisive role in host-pathogen interaction, and limitation of iron availability to microbes has been characterized as an effective host defense strategy. The identification of the iron-scavenging property of the neutrophil protein calprotectin adds an important new piece to this concept of nutritional immunity.

Guenter Weiss
News & Views17 Sept 2015
Nature Chemical Biology

Volume: 11, P: 756-757
Ca²⁺ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

Susanne Ludwiczek
Igor Theurl
Guenter Weiss
Research11 Feb 2007
Nature Medicine

Volume: 13, P: 448-454
The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection

Guenter Russmueller
Rudolf Seemann
Christoph Steininger
ResearchOpen Access17 Aug 2016
Scientific Reports

Volume: 6, P: 1-8
Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Shane J. F. Cronin
Corey Seehus
Josef M. Penninger
Amendments and Corrections31 Jul 2019
Nature

Volume: 572, P: E18
Severe COVID-19 disease is associated with genetic factors affecting plasma ACE2 receptor and CRP concentrations

Verena Vogi
David Haschka
Günter Weiss
ResearchOpen Access08 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Macrophage vesicles starve bacteria of iron

Iron is a growth factor for many microbes, and its availability is critical for the course of infections. A new study uncovers a mechanism by which extracellular vesicles released by macrophages withdraw iron from the blood, thereby limiting iron access for bacteria and improving outcomes from sepsis.

Günter Weiss
News & Views19 Jan 2023
Nature Metabolism

Volume: 5, P: 10-12
Anaemia in inflammatory rheumatic diseases

Anaemia as a result of chronic inflammation is common in patients with rheumatic disease. In this Review, Weiss and Schett provide a broad overview of the topic, covering the pathogenesis, diagnosis, treatment and management of anaemia in inflammatory rheumatic disease, offering practical guidance for clinicians.

Günter Weiss
Georg Schett
Reviews13 Nov 2012
Nature Reviews Rheumatology

Volume: 9, P: 205-215
Genetic mechanisms and modifying factors in hereditary hemochromatosis

Hereditary hemochromatosis, or primary iron overload, is one of the most frequent genetic diseases in the world. This Review describes the regulation of iron metabolism and the inherited mutations that cause hereditary hemochromatosis. The author also discusses inherited and environmental modifiers that affect the severity of the disease.

Günter Weiss
Reviews17 Nov 2009
Nature Reviews Gastroenterology & Hepatology

Volume: 7, P: 50-58
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Tetrahydrobiopterin (BH4) is an enzyme co-factor that is involved in the nervous system; it is shown here to also function in T cell activation and proliferation, with roles in autoimmunity, allergic inflammation and cancer.

Shane J. F. Cronin
Corey Seehus
Josef M. Penninger
Research07 Nov 2018
Nature

Volume: 563, P: 564-568
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

Damaged erythrocytes accumulate in various pathological conditions, such as hemolytic anemia, anemia of inflammation, and sickle cell disease. In mice challenged with damaged erythorcytes, a monocyte subset migrates to the liver (but not to the spleen), and this subset differentiates into a transient macrophage population that removes the damaged erythrocytes, thus preventing organ damage.

Igor Theurl
Ingo Hilgendorf
Filip K Swirski
Research18 Jul 2016
Nature Medicine

Volume: 22, P: 945-951
Laboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection

Mario Gietl
Francesco Burkert
Katharina Kurz
ResearchOpen Access06 May 2024
Scientific Reports

Volume: 14, P: 1-10

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Calprotectin and iron match up

Ca²⁺ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Severe COVID-19 disease is associated with genetic factors affecting plasma ACE2 receptor and CRP concentrations

Macrophage vesicles starve bacteria of iron

Anaemia in inflammatory rheumatic diseases

Genetic mechanisms and modifying factors in hereditary hemochromatosis

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

Laboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection

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