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Showing 1–9 of 9 results
Advanced filters: Author: Guillaume Adelmant Clear advanced filters

  • The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA1/2 mutation carriers exhibit significant molecular alterations in normal FTs before loss of heterozygosity (LOH) occurs, and suggest that tumorigenesis in BRCA1/2 carriers requires LOH or secondary genetic events rather than haploinsufficiency alone.

    • Ian Beddows
    • Svetlana Djirackor
    • Hui Shen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and a first-in-class VCPIP1 probe with nanomolar potency.

    • Wai Cheung Chan
    • Xiaoxi Liu
    • Sara J. Buhrlage
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The development of Sulfopin, a highly selective and potent, covalent Pin1 inhibitor that phenocopies Pin1 knockout and regresses tumors in murine and zebrafish models of neuroblastoma as well as in a pancreatic cancer mouse model.

    • Christian Dubiella
    • Benika J. Pinch
    • Nir London
    Research
    Nature Chemical Biology
    Volume: 17, P: 954-963

  • Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.

    • Xiao-Feng Zheng
    • Sanket S. Acharya
    • Dipanjan Chowdhury
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Clairmont et al. find that the TRIP13 ATPase regulates REV7–Shieldin dissociation to promote homology-directed repair and suppress non-homologous end joining, and show the importance of PARPi resistance in BRCA1-deficient cancers.

    • Connor S. Clairmont
    • Prabha Sarangi
    • Alan D. D’Andrea
    Research
    Nature Cell Biology
    Volume: 22, P: 87-96

  • The complexity and dynamic range of mammalian proteomes has stymied comprehensive protein quantification for the past twenty years. Zhou et al. develop DEEP SEQ mass spectrometry and use it to quantify a murine stem cell proteome to a depth equivalent to RNA-seq-based ribosome profiling.

    • Feng Zhou
    • Yu Lu
    • Jarrod A. Marto
    Research
    Nature Communications
    Volume: 4, P: 1-11