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Genetic etiology of ventriculomegaly in 73 fetuses identified by High-Throughput sequencing

Zhao Chenyue
Xue Huiqin
Wu Jianrui
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice

Drosophila Bap180 is induced by immune deficiency/Relish in response to both pathogenic and commensal bacteria. Bap180 can feedback to restrain immune deficiency signalling and repress pro-inflammatory gene eiger (TNF), limiting tissue damage and elongating life span.

Xiaomeng He
Junjing Yu
Hong Tang
Research18 Apr 2017
Nature Microbiology

Volume: 2, P: 1-13
Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris

Pityriasis rubra pilaris (PRP) is a chronic immune‐mediated papulosquamous dermatosis and is caused by dysregulation of keratinocytes. Here the authors identify keratin 32 (KRT32) mutations associated with PRP which results in the inhibitory function of KRT32 towards NF-kB signalling and IKK complex formation being reduced.

Peidian Shi
Wenjie Chen
Furen Zhang
ResearchOpen Access24 Jul 2024
Nature Communications

Volume: 15, P: 1-18
Transient naive reprogramming corrects hiPS cells functionally and epigenetically

A new reprogramming strategy used to produce human induced pluripotent stem cells from somatic cells results in epigenetic and functional profiles that are highly similar to those of human embryonic stem cells.

Sam Buckberry
Xiaodong Liu
Ryan Lister
ResearchOpen Access16 Aug 2023
Nature

Volume: 620, P: 863-872
Reprogramming roadmap reveals route to human induced trophoblast stem cells

Single-cell transcriptomics roadmap of human dermal fibroblasts reprogrammed to primed and naive pluripotency reveals a route for the direct reprogramming of somatic cells into induced trophoblast stem cells.

Xiaodong Liu
John F. Ouyang
Jose M. Polo
Research16 Sept 2020
Nature

Volume: 586, P: 101-107
Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

Human fibroblasts are reprogrammed to generate blastocyst-like structures called iBlastoids, which recapitulate aspects of embryo implantation.

Xiaodong Liu
Jia Ping Tan
Jose M. Polo
Research17 Mar 2021
Nature

Volume: 591, P: 627-632
Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.

Alexandra Grubman
Xin Yi Choo
Jose M. Polo
ResearchOpen Access21 May 2021
Nature Communications

Volume: 12, P: 1-22
Be₁₂O₁₂ Nano-cage as a Promising Catalyst for CO₂ Hydrogenation

Haiyan Zhu
Yawei Li
Qiang Sun
ResearchOpen Access18 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
A donor-DNA-free CRISPR/Cas-based approach to gene knock-up in rice

This study reports a donor DNA-free approach for gene knock-up based on CRISPR. It induced designed promoter swap or replacement for target genes by triggering genomic inversion or duplication so as to elevate gene expression and generate new traits.

Yu Lu
Jiyao Wang
Linjian Jiang
Research15 Nov 2021
Nature Plants

Volume: 7, P: 1445-1452
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy

Furen Zhang and colleagues report the results of a three-stage genome-wide association study of leprosy in the Chinese population. They discover six new susceptibility loci and observe substantial overlap with loci previously implicated in autoimmune and inflammatory diseases.

Hong Liu
Astrid Irwanto
Furen Zhang
Research02 Feb 2015
Nature Genetics

Volume: 47, P: 267-271
A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

Grubman et al. generated a single-cell transcriptomic atlas of the entorhinal cortex from patients with Alzheimer’s disease and identified transcription factor networks predicted to control disease progression in a cell-subtype-specific way.

Alexandra Grubman
Gabriel Chew
Jose M. Polo
Research25 Nov 2019
Nature Neuroscience

Volume: 22, P: 2087-2097

Search

Genetic etiology of ventriculomegaly in 73 fetuses identified by High-Throughput sequencing

Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice

Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris

Transient naive reprogramming corrects hiPS cells functionally and epigenetically

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Be₁₂O₁₂ Nano-cage as a Promising Catalyst for CO₂ Hydrogenation

A donor-DNA-free CRISPR/Cas-based approach to gene knock-up in rice

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

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