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Through multimodal analyses of human cardiac tissues across different ages, Fan, Zheng, Zhan, Xu, Liu and colleagues reveal that RNA-binding protein ARID5A drives inflammaging by stabilizing the MAVS mRNA and activating the NF-κB–TBK1 pathway, and show that inactivating myocardial ARID5A attenuates cardiac senescence and functional decline.

He et al. report a two-transistor-two-resistor core unit based synaptic kernel with monolithic 3D heterogeneous integration compatibility, showing compelling performance, yield (91.2%), and component uniformity. Synaptic kernel supporting differential weight achieves beyond 85% CIFAR-10 recognition.

Chemoselective reactions of two or multiple functional groups with similar reactivities remain an ongoing challenge in chemistry. Here the authors disclosed a chemoselective reaction of enedial and observed that the high chemoselectivity is mainly controlled via redox (rather than steric) properties of the substrate/catalyst.

The exact mechanism for superconductivity in iron-based superconductors remains elusive, but is thought to involve complex interactions between many orbitals. Using angle-resolved photoelectron spectroscopy, Liuet al. report the electronic structure of the single-layer parent compound FeSe.

Propane dehydrogenation is challenging to perform under mild conditions due to the reaction’s endothermic nature. Now, near-ambient propane dehydrogenation has been shown using copper single-atom catalysts supported on titanium oxide under light illumination and a water vapour environment.

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

Two-photon-pumped dye lasers are useful for applications such as biological imaging; however, loss processes reduce their efficiency. Here, metal-organic frameworks, into which the laser dye is incorporated, demonstrate enhanced laser operation because losses such as dye aggregation-caused quenching are reduced.

Cyanobacteria mutants with improved tolerance to combined high light and high temperature (HLHT) are rarely reported. Here, the authors use a hypermutation system for adaptive laboratory evolution and identify a mutant with improved HLHT tolerance by enhancing expression of shikimate kinase.

Eurasian grasslands have high production sensitivity to extreme drought compared with North American grasslands.

Nanotwinning strategies are widely recognized for their ability to substantially enhance the mechanical properties of materials. Here diamond with both penetrating and interlocked twins was synthesized, yielding a hardness of 276 GPa, which can be explained by diamond models that feature diverse twin configurations and dimensions.

A sulfur-rich covalent organic framework with low-valence Pt single atom sites is reported for photocatalytic hydrogen evolution. The material was stable under reaction conditions due to reduced hydrogen desorption barriers and enhanced charge separation.

The authors report a wet-chemistry-based method to fabricate amorphous, transferable high-k copper calcium titanate thin films as dielectrics for two-dimensional electronic devices.

Primary biliary cholangitis is a chronic autoimmune disease critically linked to immunological dysregulation but the local immune-pathogenesis is poorly understood. Here the authors present single cell transcriptomic characterisation of primary biliary cholangitis and implicates Th1 like cells in a murine model.

Ag clusters dispersed in glass are critical for optical storage media. The authors present fluorine-modified glass with high Ag⁺ ion solubility, enhancing the formation of Ag clusters under low-energy laser irradiation. The inert network effectively confines Ag clusters uniformly within the glass.

Virus-mediated somatic genetics experiments in adult mouse brain identify key roles of LKB1 and SIK3 upstream of HDAC4/5 and CREB in the transcriptional regulation of non-rapid eye movement sleep.

During prolonged ABA signalling, N-glycosylation-mediated nucleus-peroxisome subcellular dynamics of SnRK2s orchestrate a transition state from short-term sensitive response to long-term acclimation to environmental stress.

The mechanism of high-temperature superconductivity in the iron-based materials remains not fully understood. Here, the authors report on ARPES measurements on an FeSe-based bulk superconductor, whose electronic properties are found to be similar to those of single-layer FeSe/STO films.

The critical temperature of single-layer FeSe films is much higher than the bulk of other iron-based superconductors, but the mechanism for this is unclear. Adding to the puzzle, Liu et al.show that it is much more difficult to induce superconductivity in a double-layer FeSe film than a single layer.

In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise the role of EMC in facultative heterochromatin assembly and gene silencing.

The researchers improve the properties of halide perovskite for high-performance X-ray detection by edge-defined film-fed crystal growth. In particular, high resistivity, low trap density, suppressed ion migration and reduced leakage current are demonstrated. They enable detectors with an extremely low detection limit and high sensitivity.

The Mexican axolotl is a well-established tetrapod model for regeneration and development. Here the authors report a scRNA-seq method to profile neotenic, metamorphic and limb development stages, highlighting unique perturbation patterns of cell type-related gene expression throughout metamorphosis.

How high the superconducting transition temperature can reach in single layer FeSe/SrTiO₃ films has been under debate. Here, the authors use Bogoliubov back-bending bands as a benchmark and demonstrate that superconductivity pairing can be realized up to 83 K in this system.

According to conventional wisdom, angle-resolved photoemission spectroscopy (ARPES) can only measure the magnitude of the superconducting gap but not its phase. Here, the authors propose a new method to directly detect the superconducting gap phase using ARPES and validate this technique on a cuprate superconductor.

Fermi arcs, which are open-ended gapless sections in the large Fermi surface, have been observed in the pseudogap state of high-transition-temperature (high-T_c) copper oxide superconductors rather than the closed loop expected of an ordinary metal. This is all the more puzzling because Fermi pockets have been suggested by recent quantum oscillation measurements. Fermi pockets are now measured in a high-T_c copper oxide superconductor and, surprisingly, they appear to coexist with the Fermi arcs.

Recently, superconductivity near 80 K was observed in La3Ni2O7 under high pressure, but the mechanism is debated. Here the authors report angle-resolved photoemission spectroscopy measurements under ambient pressure, revealing flat bands with strong electronic correlations that could be linked to superconductivity.

Topological insulators like bismuth selenide exhibit Dirac surface states in which the electron spin is locked with the crystal momentum. Using spin- and angle-resolved photoemission spectroscopy, the authors observe a new kind of coupling between the spin and orbital texture of the Dirac cones.

Measurements of the electronic structure of a trilayer cuprate superconductor suggest that its high critical temperature is explained by the different doping levels of the layers. The combination of underdoped inner layer and overdoped outer layers supports superconductivity.

The unconventional superconductivity associated with iron pnictide materials has been the subject of intense interest. Using an annealing procedure to control the charge-carrier concentration, the behaviour of an FeSe monolayer deposited on SrTiO₃ is now investigated, and indications of superconductivity at temperatures up to 65 K observed.

Modifying plant lignin pathway to enhance saccharification efficiency is often associated with growth penalty. Here, the authors show that overexpression of Pag-miR408 in poplar leads to enhanced saccharification efficiency and growth in both laboratory and field conditions, and laccase genes are the targets of Pag-miR408.

The impact of the charge density wave (CDW) state to the electronic structure in the Kagome superconductors AV₃Sb₅ remains unclear. Here, the authors observe CDW-induced Fermi surface reconstruction with a strongly anisotropic CDW gap and signatures of the electron-phonon coupling for all V-derived bands.

Zhou, Duan, Wang et al. show that d-2-hydroxyglutarate affects mitochondrial health by inhibiting the 3-hydroxypropionate (3-HP) dehydrogenase HPHD-1, leading to a build-up of 3-HP and interference with IMMT-1 (also knowns as MIC60) function in mitochondria structure.

An untethered phototactic soft machine composed of poly(N-isopropylacrylamide) hydrogel blended with graphene oxide and gold nanoparticles demonstrates underwater full-space artificial phototaxis and manoeuvres around obstacles in natural sunlight.

High-precision photoemission measurements determine that the superconducting pairing symmetry in KFe₂As₂ is the same as in other types of iron-based superconductors, despite having different features in the band structure.

Marine ecosystems are dominated by microbial communities. Inspired by the photoelectric conversion feature of the marine ecosystems, the authors design a four-species microbial community to mimic primary producer, primary degrader, and ultimate consumers, and show its ability to convert light into electricity for over one month.

One-step separation of C2H4 from ternary C2 hydrocarbon mixtures remains a challenge for current physisorbents. Here, the authors reported a strategy of designing multiple supramolecular binding sites in a robust and scalable MOF for highly efficient one-step C2H4 purification from ternary mixtures.