Nature Search

A newly discovered mechanism driving neuronal mutations in Alzheimer’s disease

Variable brain-specific mutations have been observed in Alzheimer’s disease. One mechanism underlying this mosaicism involves integration of variant gene copies back into the neuronal genome.

Guoliang Chai
Joseph G. Gleeson
News & Views21 Nov 2018
Nature

Volume: 563, P: 631-632
Rational design of a topological polymeric solid electrolyte for high-performance all-solid-state alkali metal batteries

Solid-state polymer electrolytes are crucial for developing future rechargeable batteries, but they are still limited in performance. Here, the authors designed a topological polymeric solid electrolyte, enabling an all-solid-state high-voltage lithium metal pouch cell to cycle 200 times efficiently.

Yun Su
Xiaohui Rong
Yong-Sheng Hu
ResearchOpen Access19 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Correction: Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity

Xinyi Qi
Jinxin Qiu
Ju Qiu
Amendments and CorrectionsOpen Access23 Jul 2020
Mucosal Immunology

Volume: 14, P: 277
Dual interfacial engineering of a Chevrel phase electrode material for stable hydrogen evolution at 2500 mA cm⁻²

Stable electrodes which operate at large current density are essential for industrial water electrolysis. Here, a highly active Chevrel phase electrode is reported to achieve 2500 mA/cm⁻² current density for 300 hours at small overpotentials.

Heming Liu
Ruikuan Xie
Bilu Liu
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Somatic mosaicism reveals clonal distributions of neocortical development

A comprehensive analysis of brain somatic mosaicism across the neocortex demonstrates the origins and distribution patterns of cells within the human brain.

Martin W. Breuss
Xiaoxu Yang
Joseph G. Gleeson
Research20 Apr 2022
Nature

Volume: 604, P: 689-696
Biallelic hypomorphic mutations in HEATR5B, encoding HEAT repeat-containing protein 5B, in a neurological syndrome with pontocerebellar hypoplasia

Shereen G. Ghosh
Martin W. Breuss
Joseph G. Gleeson
Research06 Apr 2021
European Journal of Human Genetics

Volume: 29, P: 957-964
Feedback regulation of apical progenitor fate by immature neurons through Wnt7–Celsr3–Fzd3 signalling

The switch from neurogenesis to gliogenesis in cortical development is only partially understood. Here the authors show that Wnt-Planar cell polarity signaling in immature cortical neurons activates Notch in neural progenitor cells, thereby tuning the timing of their fate decisions.

Wei Wang
Yves Jossin
Andre M. Goffinet
ResearchOpen Access04 Mar 2016
Nature Communications

Volume: 7, P: 1-11
Copper-surface-mediated synthesis of acetylenic carbon-rich nanofibers for active metal-free photocathodes

While photoelectrochemical devices combine light-absorption with fuel and electricity generation, their implementation is hampered by high costs and low output. Here, the authors synthesized acetylene-rich carbon fibers by copper-mediated polymerization for high-activity, metal-free photocathodes.

Tao Zhang
Yang Hou
Xinliang Feng
ResearchOpen Access19 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Celsr3 is required in motor neurons to steer their axons in the hindlimb

In this study, the authors show that Celsr3 and Fzd3 interact in motor neurons to cooperatively direct axon guidance to target muscles in the periphery. In addition, they find that loss of Celsr3 or Fzd3 function also impairs axonal responses to ephrinA reverse, attractive signaling, suggesting a functional interaction between these guidance pathways.

Guoliang Chai
Libing Zhou
Fadel Tissir
Research10 Aug 2014
Nature Neuroscience

Volume: 17, P: 1171-1179
Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition

Shereen G. Ghosh
Sangmoon Lee
Joseph G. Gleeson
Research14 Nov 2020
Genetics in Medicine

Volume: 23, P: 524-533
Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity

Xinyi Qi
Jinxin Qiu
Ju Qiu
ResearchOpen Access01 Jul 2020
Mucosal Immunology

Volume: 14, P: 38-52
Genome-wide association study Identified multiple Genetic Loci on Chilling Resistance During Germination in Maize

Guanghui Hu
Zhao Li
Zhiwu Zhang
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Homoeologue expression insights into the basis of growth heterosis at the intersection of ploidy and hybridity in Cyprinidae

Li Ren
Wuhui Li
Shaojun Liu
ResearchOpen Access06 Jun 2016
Scientific Reports

Volume: 6, P: 1-12

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A newly discovered mechanism driving neuronal mutations in Alzheimer’s disease

Rational design of a topological polymeric solid electrolyte for high-performance all-solid-state alkali metal batteries

Correction: Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity

Dual interfacial engineering of a Chevrel phase electrode material for stable hydrogen evolution at 2500 mA cm⁻²

Somatic mosaicism reveals clonal distributions of neocortical development

Biallelic hypomorphic mutations in HEATR5B, encoding HEAT repeat-containing protein 5B, in a neurological syndrome with pontocerebellar hypoplasia

Feedback regulation of apical progenitor fate by immature neurons through Wnt7–Celsr3–Fzd3 signalling

Copper-surface-mediated synthesis of acetylenic carbon-rich nanofibers for active metal-free photocathodes

Celsr3 is required in motor neurons to steer their axons in the hindlimb

Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition

Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity

Genome-wide association study Identified multiple Genetic Loci on Chilling Resistance During Germination in Maize

Homoeologue expression insights into the basis of growth heterosis at the intersection of ploidy and hybridity in Cyprinidae

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