Nature Search

Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide

Jing Li
Li Luo
Guoping Li
Research01 Oct 2009
Cellular & Molecular Immunology

Volume: 6, P: 381-385
Induction of Th1-Type Immune Response by Chitosan Nanoparticles Containing Plasmid DNA Encoding House Dust Mite Allergen Der p 2 for Oral Vaccination in Mice

Guoping Li
Zhigang Liu
Nanshan Zhong
Research01 Feb 2009
Cellular & Molecular Immunology

Volume: 6, P: 45-50
Correction: Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

Yi Lu
Cheng Zhong
Liping Wang
Amendments and CorrectionsOpen Access14 Jun 2016
Nature Communications

Volume: 7, P: 1
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

Evidence for the treatment of patients with mild-to-moderate COPD is limited. Here, the authors show that long-term treatment with high-dose N-acetylcysteine neither significantly reduced the annual rate of total exacerbations nor improve lung function in patients with mild-tomoderate COPD.

Yumin Zhou
Fan Wu
Li Chen
ResearchOpen Access30 Sept 2024
Nature Communications

Volume: 15, P: 1-11
Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids

Here, the authors present scRICA-seq, which is capable of profiling isoforms and chromatin accessibility for up to 10,000 single cells in a single run. By applying this method to human retinal organoids, they construct a multi-omic cell atlas.

Shuyao Zhang
Yuhua Xiao
Youjin Hu
ResearchOpen Access13 Sept 2024
Nature Communications

Volume: 15, P: 1-13
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

Lymphocytic leukaemia cells are characterized by high respiratory rates. Here, the authors report that the oxysterol-binding protein ORPL4 sustains mitochondrial respiration in T-cell acute lymphoblastic leukaemia cells by regulating Ca²⁺release from the endoplasmic reticulum.

Wenbin Zhong
Qing Yi
Daoguang Yan
ResearchOpen Access01 Sept 2016
Nature Communications

Volume: 7, P: 1-14
Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation

Most single-cell RNA sequencing methods have limited ability to profile the transcriptome at isoform resolution. Here the authors develop scRCAT-seq to characterize the 5′- and 3′-ends of transcripts in single cells, and identify cell-type specific alternative transcript isoforms.

Youjin Hu
Jiawei Zhong
Yizhi Liu
ResearchOpen Access13 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

Tokhir Dadaev
Edward J. Saunders
Zsofia Kote-Jarai
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-19
Chemical-induced phase transition and global conformational reorganization of chromatin

The authors show that adriamycin induces global changes on chromatin conformation associated with phase transitions mediated through Histone H1.

Tengfei Wang
Shuxiang Shi
Chao-Po Lin
ResearchOpen Access09 Sept 2023
Nature Communications

Volume: 14, P: 1-18
Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

The network mechanism supporting seizure spread in temporal lobe epilepsy (TLE) is only partially understood. Using optogenetic methods, Lu et al.identify a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus to the medial entorhinal cortex in a mouse model of TLE.

Yi Lu
Cheng Zhong
Liping Wang
ResearchOpen Access21 Mar 2016
Nature Communications

Volume: 7, P: 1-12
An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis

The oxysterol-binding protein-related protein 4 (ORP4L) is expressed in T-cell acute lymphoblastic leukemia and is required for leukemogenesis. Here the authors show that ORP4L orchestrates the transport of the phospholipid PI(4)P from Golgi to the plasma membrane, contributing to PI3K/AKT hyperactivation and T-cell leukemogenesis.

Wenbin Zhong
Weize Lin
Daoguang Yan
ResearchOpen Access29 Jul 2022
Nature Communications

Volume: 13, P: 1-18
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Chen et al. report that the immune modulatory metabolite itaconic acid selectively inhibits the activity of TET DNA dioxygenases to repress the inflammatory responses.

Lei-Lei Chen
Carmen Morcelle
Dan Ye
Research07 Mar 2022
Nature Cell Biology

Volume: 24, P: 353-363
Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator

Qingfeng Wang
Guoping Cheng
Zhong Qing
ResearchOpen Access26 Nov 2018
Scientific Reports

Volume: 8, P: 1-7
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

This study maps the DNA methylome profile of adult mouse dentate gyrus neurons at the single-base resolution and finds prevalent methylation of both CpG dinucleotides and non-CpG cytosines (CpH). The study also shows that CpH methylation can repress transcription. Furthermore, CpH methylation is recognized by the Rett syndrome–associated protein MeCP2, which is established during neuronal maturation and maintained by DNA methyltransferase DNMT3A.

Junjie U Guo
Yijing Su
Hongjun Song
Research22 Dec 2013
Nature Neuroscience

Volume: 17, P: 215-222
Effects of land use change on runoff depth in the Songnen Plain, China

Zhong Lu
Jinliang Zhang
Ziyang Yu
ResearchOpen Access18 Oct 2024
Scientific Reports

Volume: 14, P: 1-17
Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Expression of TET1 dioxygenase, which catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, is downregulated by repeated cocaine administration in mouse nucleus accumbens, where it controls cocaine reward. Genome-wide mapping of 5-hydroxymethylcytosine in this brain region reveals novel modes of epigenetic regulation by cocaine.

Jian Feng
Ningyi Shao
Eric J Nestler
Research16 Mar 2015
Nature Neuroscience

Volume: 18, P: 536-544
Author Correction: Sparse whole-genome sequencing identifies two loci for major depressive disorder

N. A. Cai
Tim B. Bigdeli
Jonathan Flint
Amendments and Corrections11 Aug 2023
Nature

Volume: 620, P: E28
The Schistosoma japonicum genome reveals features of host–parasite interplay

Schistosoma mansoni and Schistosoma japonicum are the pathogenic agents that cause the tropical disease schistosomiasis. Here, and in an accompanying paper, the genomes of these two flatworms are sequenced and analysed. The results provide insights into the molecular architecture and host interactions of the flatworms, as well as avenues for future development of targeted interventions for schistosomiasis.

Yan Zhou
Huajun Zheng
Zhu Chen
ResearchOpen Access16 Jul 2009
Nature

Volume: 460, P: 345-351
Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation

Xiaoyun Wang
Yin Li
Guoping Li
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22

Wei Zhong
Bin Cui
Xiangyin Kong
Research28 Jun 2003
Journal of Human Genetics

Volume: 48, P: 390-392
Sparse whole-genome sequencing identifies two loci for major depressive disorder

Genomic analysis of 5,303 Chinese women with recurrent major depressive disorder (MDD) enables the identification and replication of two genome-wide significant loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene; the other in an intron of the LHPP gene.

Na Cai
Tim B. Bigdeli
Jonathan Flint
Research15 Jul 2015
Nature

Volume: 523, P: 588-591
The functional landscape of Golgi membrane protein 1 (GOLM1) phosphoproteome reveal GOLM1 regulating P53 that promotes malignancy

Qi Song
Xiang He
Guoping Li
ResearchOpen Access01 Mar 2021
Cell Death Discovery

Volume: 7, P: 1-15
Clinical utility of 24-h rapid trio-exome sequencing for critically ill infants

Huijun Wang
Yanyan Qian
Wenhao Zhou
ResearchOpen Access05 May 2020
npj Genomic Medicine

Volume: 5, P: 1-6
DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer

Shaoqiang Guo
Miaomiao Miao
Junjian Wang
Research13 Mar 2024
Oncogene

Volume: 43, P: 1399-1410
The tomato genome sequence provides insights into fleshy fruit evolution

This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

Shusei Sato
Satoshi Tabata
René M. Klein Lankhorst
ResearchOpen Access30 May 2012
Nature

Volume: 485, P: 635-641
Erratum: Elevated nitrate enriches microbial functional genes for potential bioremediation of complexly contaminated sediments

Meiying Xu
Qin Zhang
Zhili He
Amendments and Corrections20 Jan 2015
The ISME Journal

Volume: 9, P: 532
PRPF19 facilitates colorectal cancer liver metastasis through activation of the Src-YAP1 pathway via K63-linked ubiquitination of MYL9

Rui Zhou
Jie Chen
Lin Qiu
ResearchOpen Access08 Apr 2023
Cell Death & Disease

Volume: 14, P: 1-14
TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

Haiyun Chen
Hongjie Chen
Jianliang Jin
ResearchOpen Access21 Jan 2020
Experimental & Molecular Medicine

Volume: 52, P: 130-151
Elevated nitrate enriches microbial functional genes for potential bioremediation of complexly contaminated sediments

Meiying Xu
Qin Zhang
Zhili He
Research27 Mar 2014
The ISME Journal

Volume: 8, P: 1932-1944

Search

Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide

Induction of Th1-Type Immune Response by Chitosan Nanoparticles Containing Plasmid DNA Encoding House Dust Mite Allergen Der p 2 for Oral Vaccination in Mice

Correction: Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids

ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Chemical-induced phase transition and global conformational reorganization of chromatin

Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

Effects of land use change on runoff depth in the Songnen Plain, China

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Author Correction: Sparse whole-genome sequencing identifies two loci for major depressive disorder

The Schistosoma japonicum genome reveals features of host–parasite interplay

Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation

Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22

Sparse whole-genome sequencing identifies two loci for major depressive disorder

The functional landscape of Golgi membrane protein 1 (GOLM1) phosphoproteome reveal GOLM1 regulating P53 that promotes malignancy

Clinical utility of 24-h rapid trio-exome sequencing for critically ill infants

DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer

The tomato genome sequence provides insights into fleshy fruit evolution

Erratum: Elevated nitrate enriches microbial functional genes for potential bioremediation of complexly contaminated sediments

PRPF19 facilitates colorectal cancer liver metastasis through activation of the Src-YAP1 pathway via K63-linked ubiquitination of MYL9

TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

Elevated nitrate enriches microbial functional genes for potential bioremediation of complexly contaminated sediments

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