Search

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

The epigenetic mechanisms underlying phenotypic diversity across different metastatic sites in castration-resistant prostate cancer (CRPC) remain to be characterised. Here, multi-omic profiling across metastatic lesions identifies regulatory networks driving tumour lineage programs and potential therapeutic targets.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Stabilizing lithium-metal anodes is challenging due to their high reactivity with electrolytes. This work presents a dual-passivation polymer coating that enhances solid–electrolyte interphase stability, improving cycling performance and increasing capacity retention over extended cycles.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver disease in humans.

A quantum simulation of a (2 + 1)-dimensional lattice gauge theory is carried out on a quantum computer working with neutral atoms trapped by optical tweezers in a Kagome geometry.

Here, the authors identify distinct gut microbiome and metabolome signatures in microscopic colitis, a condition causing chronic diarrhea, highlighting pro-inflammatory species and metabolites as potential non-invasive biomarkers and therapeutic targets.

Lewis acid additive semicarbazide hydrochloride improves the formation of α-phase FAPbI₃-based films and promotes a homogeneous vertical distribution of A-site cations through a deprotonation–reprotonation process. The upgraded device performance reaches up to 26.12% with high stability, and mini-module perovskite solar cells achieving 21.47% (area, 11.52 cm²) demonstrate great scalability.

Sustainable management of soil organic carbon (SOC) in farmland is critical for mitigating climate change and improving soil health. Degradable film mulching is a promising alternative to plastic film mulching, sequestering SOC and reducing C loss in dryland agroecosystems under climate change.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

In patients with advanced cancer, the development of brain metastasis (BM) often signals a worsening prognosis with limited therapeutic options. Here, the authors assemble a large, open-source neuroimaging dataset of BM and perform spatial and morphological analysis which they use to develop a framework for function-sparing brain radiotherapy design.

Purifying C₂H₂ by removing trace CO₂ is needed but challenging due to their analogous physical properties. Herein, the authors report the pilot-scale production of a commercial resin adsorbent loaded with polyethyleneimine for the selective capture of CO₂ traces and exclusion of C₂H₂.

Achieving both high activity and selectivity in CH₄ photooxidation to C₂₊ hydrocarbons is challenging. This work shows that integrating photochemical and photothermal effects enhances both, enabling efficient CH₄ oxidative coupling to C₂₊ alkanes.

Teixobactin is a recently identified antibiotic that shows activity against drug resistant strains of bacteria. Here, the authors report a highly convergent total synthesis of this natural product, with sufficient flexibility to also allow the synthesis of a number of analogues.

A study reports on the antigenic characterization of SARS-CoV-2 BA.1, BA.1.1 and BA.2 and the neutralizing activity of different monoclonal antibodies and sera against them.

The authors show PTEN mutations, which can cause both congenital hydrocephalus and autism spectrum disorder, disrupt CSF homeostasis and brain connectivity in mice. Reducing mTORC1 activation ameliorates ventricular enlargement and neuronal deficits.

The majority of growth references for preterm infants were assumed to reflect intrauterine growth. Here, the authors identify postnatal growth patterns of very preterm infants that are distinctly different than intrauterine growth.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

The critical floating phase can bridge crystalline orders and the disordered phase. Here, the authors experimentally observe the quantum floating phase in neutral atom qubit arrays, revealing ___domain walls and incommensurate quasi long-range order, and analyse its emergence via Fourier spectroscopy.

A new acid-degradable linker termed ‘azido-acetal’ has been developed that rapidly hydrolyses at pH 6.0 but is stable at pH 7.4. Lipid nanoparticles made with this linker delivered mRNA in vivo and in vitro better than traditional lipid nanoparticles.

Here, the authors introduce METRIC, a deep-learning method that corrects measurement errors in self-reported dietary nutrient profiles using assessed data and microbial composition, effectively enhancing dietary accuracy.

Silicon dioxide is one of the most abundant natural compounds and its various crystalline phases are widely studied. Here, using synchrotron X-ray diffraction and theoretical modelling, the authors discover a polymorphic phase transition involving previously unknown triclinic phases of silicon dioxide.

Metal halide perovskites have been studied as promising materials for blue light-emitting diodes (LEDs) but the stability is still a bottleneck. Here Wang et al. develop a chelating additive strategy to increase efficiency, operational stability and color stability of blue perovskite LEDs.

Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal ___domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.

A cluster randomized trial in China shows that telemedicine-based, village doctor-led delivery of integrated care reduced the occurrence of adverse cardiovascular events and hospitalizations in older adults with atrial fibrillation.

Touch-guided tongue control in mice relies on a collicular mechanosensorimotor map, analogous to collicular visuomotor maps associated with visually guided orienting across many species.

The observation of superconductivity in infinite-layer nickelates has been limited to epitaxial thin films, which has restricted their experimental investigation. Now, a technique is reported for the release of millimetre-scale freestanding superconducting nickelate membranes. This geometry enables a range of studies, including the response of superconductivity to strain.

The study of nematic hosts with anisotropic colloidal particles is reported, but not on the chiral counterparts. Here, the authors report on biaxial properties in a system of colloidal rods with designed surface anchoring doped into a chiral nematic host.

The PSA (KLK3) genetic variant rs17632542 is associated with reduced prostate cancer risk and lower serum PSA levels, although the underlying reasons are unclear. Here, the authors show that this PSA variant reduced proteolytic activity and leads to smaller tumours, but also increases invasion and bone metastasis, indicating its dual risk association depending on tumour context; the variant is associated with both lower risk and poor clinical outcomes.

A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group.

Fabricating and mechanically testing nanoarchitected materials remains a challenge. Here, the authors use colloidal synthesis to fabricate Au-Ag hollow nanoboxes and investigate the effect of either a rough or a smooth nanobox surface on the mechanical properties.

A molecular aggregate formed in a two-dimensional organic–inorganic hybrid perovskite superlattice with a near-equilibrium distance is shown to have a near-unity photoluminescence quantum yield like that of single molecules, despite being in an aggregated state.

Asymmetric histone modifications in parental pronuclei displays epigenetic regulation. Here the authors reveal the role of LSM1-mediated Major Satellite RNA decay in the H3 variant incorporation and modifications in male pronucleus.

Defect-free monolayers of graphene and hexagonal boron nitride are highly permeable to thermal protons, but are impenetrable to gases. Here the authors show that mechanically exfoliated crystals exhibit perfect proton selectivity, corroborating proton transport through the bulk without atomic-scale defects.

The stability of perovskite tandem solar cells is an issue. Li et al. show that diamines improve the compositional homogeneity of a low-bandgap perovskite surface and form a low-dimensional barrier that passivates defects, leading to an operational stability of over 1,000 h.

The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer’s disease. Here the authors report that HTRA1 inhibits aggregation of α-syn as well as FUS and TDP-43, which are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

This study investigates the genetic similarities and differences between two subtypes of glaucoma (normal tension and high tension). Multi-ethnic meta-analysis reveals overlapping risk loci, with a lower effect magnitude in normal tension glaucoma. The authors also use their gene discovery approach to highlight possible neuro-protective drug targets for glaucoma.