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Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity

Influenza A virus (IAV) and SARS-CoV-2 coinfection is a possible scenario during influenza season. Here, the authors show in a mouse model that IAV infection increases the risk of severe disease upon SARS-CoV-2 infection two days later. IAV vaccination, especially antibody-dependent, protects from severe disease during coinfection.

Hagit Achdout
Einat. B. Vitner
Tomer Israely
ResearchOpen Access05 Oct 2021
Nature Communications

Volume: 12, P: 1-10
Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

In this study, the authors show that a single dose of a combination of two human-like monoclonal antibodies protect mice in therapeutic treatment against challenges with ectromelia virus and monkeypox virus. Combination treatment provided more effective viral clearance than single antibody treatment.

Hadas Tamir
Tal Noy-Porat
Tomer Israely
ResearchOpen Access16 Apr 2024
Nature Communications

Volume: 15, P: 1-10
A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the vaccine.

Yfat Yahalom-Ronen
Hadas Tamir
Tomer Israely
ResearchOpen Access16 Dec 2020
Nature Communications

Volume: 11, P: 1-13
The coding capacity of SARS-CoV-2

A high-resolution map of coding regions in the SARS-CoV-2 genome enables the identification of 23 unannotated open reading frames and quantification of the expression of canonical viral open reading frames.

Yaara Finkel
Orel Mizrahi
Noam Stern-Ginossar
Research09 Sept 2020
Nature

Volume: 589, P: 125-130
A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding ___domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, which show efficient neutralizing activities against authentic virus in vitro.

Tal Noy-Porat
Efi Makdasi
Ronit Rosenfeld
ResearchOpen Access27 Aug 2020
Nature Communications

Volume: 11, P: 1-7
The activating receptor NKp46 is essential for the development of type 1 diabetes

Natural killer cells infiltrate the pancreas during type 1 diabetes. Mandelboim and co-workers find that the natural killer receptor NKp46 recognizes ligands on pancreatic beta cells and is essential for full diabetes development.

Chamutal Gur
Angel Porgador
Ofer Mandelboim
Research20 Dec 2009
Nature Immunology

Volume: 11, P: 121-128
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus

Tal I Arnon
Hagit Achdout
Ofer Mandelboim
Research10 Apr 2005
Nature Immunology

Volume: 6, P: 515-523
Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

Roi Gazit
Raizy Gruda
Ofer Mandelboim
Research26 Mar 2006
Nature Immunology

Volume: 7, P: 517-523
Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments

Yaron Vagima
David Gur
Emanuelle Mamroud
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-16

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Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity

Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

The coding capacity of SARS-CoV-2

A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

The activating receptor NKp46 is essential for the development of type 1 diabetes

Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus

Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments

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