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Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy

The immune response of immunotherapy in colorectal cancer remains low and new adjuvant targets are in demand. By in vivo CRISPR-Cas9 screening that targets membrane and secreted proteins genes, the authors identify that disrupting MBTPS1 in tumor cells upregulates STAT1-transcribed chemokines, promotes CXCR3⁺ CD8 T cells infiltration and potentiates anti-PD-1 therapy.

Yi-Yu Wang
Jin-Fei Lin
Rui-Hua Xu
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-21
Nucleus-translocated GCLM promotes chemoresistance in colorectal cancer through a moonlighting function

Platinum-based therapies are a key component of colorectal cancer therapy, but patients often become resistant. Here, the authors identify a non-canonical function of glutamate-cysteine ligase modifier (GCLM) wherein its nuclear translocation increases NF-κB activity promoting resistance to platinum-based chemotherapy in colorectal cancer.

Jin-Fei Lin
Ze-Xian Liu
Rui-Hua Xu
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Slow cooling and efficient extraction of C-exciton hot carriers in MoS₂ monolayer

Light-matter interaction in atomically thin transition metal dichalcogenides is dominated by excitonic effects and hot-carrier relaxation/extraction mechanisms. Here, the authors report that the C exciton in two-dimensional MoS₂exhibits a slower hot-carrier cooling than band-edge excitons.

Lei Wang
Zhuo Wang
Hong-Bo Sun
ResearchOpen Access05 Jan 2017
Nature Communications

Volume: 8, P: 1-8
Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer

Chen Wei
Kun Liao
Rui-Hua Xu
ResearchOpen Access28 Apr 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-17
The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

The suppressive immune microenvironment in colorectal cancer (CRC) liver metastasis remains to be explored. Here, the authors find tumor-associated macrophages in the liver microenvironment induces elevated secretion of FGL1 from cancer cells and hepatocytes which promotes CRC metastasis by suppressing the infiltration of T cells.

Jia-Jun Li
Jin-Hong Wang
Huai-Qiang Ju
ResearchOpen Access23 Oct 2023
Nature Communications

Volume: 14, P: 1-18
A two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients

Jia-huan Lu
Zhi-xiang Zuo
Zhao-lei Zeng
ResearchOpen Access18 Dec 2018
Cell Death Discovery

Volume: 4, P: 1-12
Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway

Yun-Xin Lu
Dong-Liang Chen
Rui-Hua Xu
ResearchOpen Access27 Oct 2016
Cell Death & Disease

Volume: 7, P: e2432

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Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy

Nucleus-translocated GCLM promotes chemoresistance in colorectal cancer through a moonlighting function

Slow cooling and efficient extraction of C-exciton hot carriers in MoS2 monolayer

Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer

The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

A two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients

Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway

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Slow cooling and efficient extraction of C-exciton hot carriers in MoS₂ monolayer