Genomic mutations can be translated into modified functional proteins, impacting protein–protein interactions (PPIs) and thus altering cellular functions. In this Review, Fu, Mo and Ivanov summarize the mechanisms by which oncogenic mutations impact PPIs, technologies for monitoring this, the categories and features of PPIs in cancer, and finally the therapeutic implications of this.
- Haian Fu
- Xiulei Mo
- Andrey A. Ivanov
