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Spatiotemporally activating DC cells in lymph nodes (LN) for cancer vaccine therapy remains a challenge. Here the authors combine antigen loaded STING nanoadjuvants with LN-confined laser or ultrasound stimulation to activate DC cells, sequentially enhances antigen-specific CD8⁺ T cell response and reduces tumor size.

The authors propose a high entropy modulation design in a quantum paraelectric ferroelectric/antiferroelectric matrix, showing high energy storage performance. Through entropy engineering, the microstructure of the material is changed with higher fluctuation on the B-site of the perovskite.

Cryo-EM reveals an asymmetric bacterial photosynthetic supercomplex built upon a homodimeric reaction center core. The structure provides mechanistic insights into light excitation transfer and a possible evolutionary transition intermediate of photosynthetic machinery.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

The conductance from bulk bands in a topological insulator usually blurs effects arising from edge states. Here, Song et al. report a Coulomb gap opened by electron–electron interactions, which effectively suppress the bulk conductance and promote observation of topological edge states in the single-layer 1T’-WTe₂.

SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.

Valley states can be used to realise topologically protected transport. Here, He et al. show that considering additional degrees of freedom, together with glide symmetry, allow the design of 2D acoustic topological pseudospin-valley coupled saddle surface states in 3D structures.

A new aluminosilicate zeolite called ZMQ-1 is introduced that has an intrinsic meso-microporous channel system and shows high thermal and hydrothermal stability and tunable framework Si/Al molar ratios.

Antitumor performance of PROteolysis-TArgeting Chimeras (PROTACs) is limited by their targeting ability and retention to tumor sites. Here the authors design the reactive oxygen species (ROS)-activatable and hypoxia-responsive PROTAC nanoparticles with selective penetration into tumors for degradation of BRD4 to suppress breast and head and neck cancer progression.

Controlling the properties of transition metal chalcogenides enables the study of new condensed-matter phenomena and the development of potential applications. Here, the authors continuously tune the crystal and electronic structure of molybdenum diselenide away from the pristine state using pressure.

Introduction of any interface will inevitably lead to a decrease in carrier mobility. Here, authors employ atomic layer deposition technology to construct composite phase interfaces, decoupling the interrelated thermoelectric parameters in n-type ZrNiSn materials.

The authors develop a general method that combines machine learning and physics to construct macroscopic dynamics directly from microscopic observations, leading to an intuitive understanding of polymer stretching in elongational flow.

Mercury isotope signatures in groundwater, soil gas, solid peat, and atmosphere suggest that dark abiotic reduction of peat soil Hg^II to volatile Hg⁰ does not play a significant role in mobilizing Hg during peat mass loss

Converting solar energy to hydrogen fuel requires light-absorbers that well-match the wavelengths of incoming sunlight. Here, authors prepare a broadband visible-light-absorbing molecular complex that efficiently produces hydrogen from water.

The magnetic exchange interaction of MnBi₂Te₄—an intrinsic magnetic topological insulator—can be tuned by intercalating ferromagnetic layers of MnTe.

Proteolysis targeting chimeras (PROTACs) have emerged as promising cancer therapy agents but have suffered from systemic toxicity issues. Here, the authors report on the creation of polymeric PROTAC nanoparticles for tumour targeting delivery and demonstrate protein degradation in vivo, in combination with photodynamic therapy.

Large-area single-crystal high-index copper and nickel foils with several types of facet are fabricated using mild pre-oxidation of the metal foil surface followed by annealing in a reducing atmosphere.

A Type II Weyl fermion semimetal has been predicted in Mo_xW_1−xTe₂, but it awaits experimental evidence. Here, Belopolski et al. observe a topological Fermi arc in Mo_xW_1−xTe₂, showing it originates from a Type II Weyl fermion and offering a new platform to study novel transport phenomena in Weyl semimetals.

Targeting the TGF-β signaling pathway has been exploited to relieve immunosuppression in the tumor microenvironment. Here the authors describe the design of a nanoplatform integrating the TGF-β receptor 1 inhibitor LY2157299 and the ROS-responsive JQ1 pro-drug, promoting anti-tumor immune responses in preclinical cancer models.

Targeting regulatory T cells (Treg) represents a therapeutic option to abrogate tumor-associated immune suppression. Here the authors show that pharmacological degradation of BCL-X_L preferentially induces apoptosis of tumor-infiltrating Treg, promoting CD8 T cell activation and anti-tumor immune responses in preclinical cancer models.

Development of suitable methanol oxidation reaction catalysts for direct methanol fuel cells is challenging due to sluggish kinetics. Herein, authors show that four-coordinate nickel atoms form charge-transfer orbitals near the Fermi energy level, leading to remarkable methanol oxidation activity.

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

Dongxin Lin and colleagues report a genome-wide association study for esophageal squamous cell carcinoma (ESCC) in Chinese populations, identifying nine new susceptibility loci. They also perform a genome-wide gene-environment interaction analysis with alcohol consumption, a known risk factor for ESCC.

Acoustic sensors have myriad important applications, but they are limited by their pressure sensitivity. Chen et al.show how the use of graded anisotropic acoustic metamaterial structures can help overcome this by amplifying the acoustic waves via compression effects.

There is crosstalk between the maintenance of DNA methylation and histone methylation. Here, the authors create an Uhrf1 knockin mouse model that abolishes the H3K9me2/3-binding activity of Uhrf1, and show that DNA maintenance methylation in mammals is largely independent of H3K9 methylation.

High-capacity and structural stable cathode materials are challenges for sodium-ion batteries. Here, the authors report a layered P2-Na_0.612K_0.056MnO₂ with large-sized K⁺ riveted in the Na-layers to enable 0.9 Na⁺ (de)insertion with a reversible phase transition of P2-P’2.

Control of the directional photocurrent by polarized light in topological insulators may enable topological spintronics but is not yet well understood. Here the authors demonstrate that the directional photocurrent is due to the asymmetric optical transitions between topological surface states and bulk states.

Cancer vaccines represent a promising personalized therapeutic approach to treating cancer. Here, the authors report the efficacy in a metastatic model of a cancer vaccine-mediated postoperative immunotherapy, based on the coencapsulation of the JQ1 and a photosensitizer ICG together with inactivated tumor cells into a hydrogel matrix.

Identifying active sites and designing rationally heterogeneous catalysts are not inherently straightforward due to their complexity. Here, the authors reveal the nature of active sites for efficient C–H bond activation in C1-C4 alkanes over bare ZrO₂ and provide fundamentals for controlling their concentration.

Yinghao Sun and colleagues report a genome-wide association study for prostate cancer in Han Chinese men. They identify two new risk-associated loci at chromosomes 9q31 and 19q13.