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Showing 1–3 of 3 results
Advanced filters: Author: Hailey I. Edelstein Clear advanced filters

  • Understanding principles that govern protein association with extracellular vesicles should expand their potential as a therapeutic modality. Here, the authors show that by localizing proteins to the plasma membrane and lipid rafts, a variety of proteins can be preferentially loaded into extracellular vesicles.

    • Justin A. Peruzzi
    • Taylor F. Gunnels
    • Neha P. Kamat
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Engineering mammalian cellular functions requires a toolkit of orthogonal and well-characterized genetic components. Here the authors develop COMET: an ensemble of transcription factors, promoters, and accompanying models for the design and construction of genetic programs.

    • Patrick S. Donahue
    • Joseph W. Draut
    • Joshua N. Leonard
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19

  • Synthetic receptor signaling systems have evolved as platforms for user-controlled programming of cellular functions. This Perspective reviews these advances and defines a metrics-based engineering workflow to support future engineering efforts.

    • Janvie Manhas
    • Hailey I. Edelstein
    • Leonardo Morsut
    Reviews
    Nature Chemical Biology
    Volume: 18, P: 244-255