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An aromatic metallo-annulene, comprising a 15-carbon macrocycle enclosing an osmium complex, with the metal residing within the plane of the macrocycle is reported.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

Design of hydrogen evolution catalysts needs to balance the hydrogen adsorption energy to facilitate easy adsorption and desorption. Here, the authors report a composite catalyst where hydrogen adsorption occurs on rhodium and desorbs from silicon which has a lower adsorption energy.

Radialenes have distinct structural, electronic and chemical properties from other hydrocarbons, but their synthesis remains a challenge. Here, the authors report a copper catalyzed one-step synthetic protocol of [4]radialene via the cyclotetramerization of phenylacetylene molecules upon thermal activation.

Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here, the authors show that methylcobalamin in base-off conformation coordinates to Cys180 in GSDME to prevent caspase-3/GzmB-GSDME interactions and thereby GSDME-mediated liver failure.

Identifying new, active material phases provides a promising avenue in the development of efficient catalysts. Here, authors demonstrate a metastable 1T-phase IrO₂ metallene oxide as an oxygen evolution electrocatalyst in acidic electrolytes.

Radicals are expected to be inactive on metal surfaces. Here the authors describe general intermolecular radical transfer reactions on Ag and Cu surfaces and confirm the reaction mechanism by extensive control experiments.

A correlated structural and chemical evolution of silicon and the solid–electrolyte interphase was unveiled in three dimensions by integrating sensitive elemental tomography, an advanced algorithm and cryogenic scanning transmission electron microscopy.

Keto-enol tautomerism offers a promising platform for modulating charge transport at the nanoscale. Here, the authors show that the keto-enol equilibrium can be modulated on the single-molecule scale by controlling charge injection in a two-terminal junction system.

An individual-particle passivation strategy that reduces ion migration in perovskite nanocrystal film can be used to make high-refresh-rate active-matrix displays with microsecond response times reduced by three orders of magnitude compared with typical perovskite light-emitting diodes.

Reactions induced by σ-aromaticity are uncommon compared with those induced by π-aromaticity. Now, a π- and σ-aromaticity relay strategy is developed to realize the ring contraction of metallacyclobutadiene to metallacyclopropene. This reaction involves the release of π-antiaromaticity to afford a π-aromatic intermediate, followed by ring reclosure to form σ-aromatic metallacyclopropene.

Covalently bridged π-stacked dimers are excellent molecular platforms for understanding the relationship between stacking orientation and properties. Here, the authors synthesize a pair of π-stacked dimers that are aligned either cofacially or crosswise, allowing them to compare how the intramolecular stacking mode affects each dimer’s photoswitching properties.

Azulene-based conjugated systems are of great interests due to their unusual structures and photophysical properties but incorporation of a transition metal into azulene skeleton presents remains elusive. Here, the authors describe an efficient [5 + 2] annulation reaction for the rapid construction of a metalla-dual-azulene.

The combination of neoadjuvant nivolumab, ipilimumab and chemotherapy showed promising efficacy in patients with resectable non-small cell lung cancer, with higher tumor immune cell infiltration and tertiary lymphoid structures after treatment compared with neoadjuvant nivolumab plus chemotherapy.

Metal-carbon σ bonds mark the basis of organometallic chemistry, but the formation of multiple such bonds between single organic and metal entities remains a challenge. Here, the authors report a one-pot aromaticity-driven method to construct osmium-based multidentate complexes containing three metal-carbon σ bonds from multiyn chains.

Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the authors report an organocatalytic transisopropenylation approach for IPPE synthesis in mild reaction conditions and with wide range of substrates, and use it to prepare acid-sensitive ketal-linked prodrugs and biomaterials.

Pentalyne — a bicyclic anti-aromatic molecule that contains a strained five-membered ring — is a challenging synthetic target. Incorporation of an osmium centre has been shown to stabilize such features and enable the preparation of two osmapentalyne derivatives. Despite featuring the smallest angles observed so far at a carbyne moiety, these molecules benefit from Möbius aromaticity and reduced ring strain.

Cations are used to control the interlayer spacing of graphene oxide membranes, enabling efficient and selective sieving of hydrated cations.

Direct methane conversion to high value-added products is a promising way for highly-efficient utilization of methane. Here, the authors demonstrate that rhodium single-atom supported on cerium dioxide nanowires can selectively convert methane to oxygenates under mild conditions.

Coordination complexes based on polydentate ligands that contain both nitrogen and carbon ligating atoms are ubiquitous, but design of those with planar cores remains challenging. Here the authors show that complexes with planar CCCN, CCCCN and NCCCN cores can be accessed by modification of the coordinating atoms in CCCC core complexes.

A cooperative reaction is reported whereby the halogenation of one silicon atom on a surface is shown to induce, invariably, halogenation of a neighbouring silicon. This is a first step towards using surface-propagated cooperative reactions to create molecular-scale patterns on surfaces.

The recoil of adsorbates away from and towards surfaces is well-known. Here, long-range recoil in the plane of the surface, which leads to reaction at a distance, is described. Surface reactions are shown to propel their physisorbed ethylenic products across the rough surface of Si(100) by up to 200 Å before re-attachment.

Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein interaction partners and crosslinking sites.

The Brassica rapa Genome Sequencing Project Consortium reports the draft genome of the B. rapa accession Chiifu-401-42, an inbred Chinese cabbage line. The B. rapa genome should provide a useful reference genome for the Brassica species, which include many important oil and vegetable crops.

How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.

DNA damage induces translocation of cyclic GMP–AMP synthase to the nucleus, where it suppresses homologous recombination by interfering with the formation of the PARP1–Timeless complex.

This protocol describes strategies for the characterization of transient protein–protein interactions and their interaction interfaces via genetically encoded releasable photo-cross-linkers.