Nature Search

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5⁺ basal cells

Kathiriya et al. report that fibrotic signalling in the lung mesenchyme leads to transdifferentiation of human alveolar type 2 cells into KRT5⁺ basal cells, providing a mechanistic explanation for the pathology associated with severe lung injuries.

Jaymin J. Kathiriya
Chaoqun Wang
Tien Peng
Research30 Dec 2021
Nature Cell Biology

Volume: 24, P: 10-23
Gli1⁺ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

Cassandras et al. show that Gli1-expressing mesenchymal stromal cells promote metaplastic differentiation of airway progenitors into basal cells by antagonizing BMP signalling in lung fibrosis.

Monica Cassandras
Chaoqun Wang
Tien Peng
Research12 Oct 2020
Nature Cell Biology

Volume: 22, P: 1295-1306
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Xi et al. show that after influenza infection, hypoxia drives Notch signalling to expand Krt5⁺ basal-like cells in the lung. On HIF1α loss, epithelial progenitors directly differentiate into alveolar type II cells and promote functional regeneration.

Ying Xi
Thomas Kim
Andrew E. Vaughan
Research24 Jul 2017
Nature Cell Biology

Volume: 19, P: 904-914
Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

Lineage-tracing experiments identify a rare, undifferentiated population of quiescent cells in the mouse distal lung that are activated through a Notch signalling pathway to repair the epithelium after bleomycin- or influenza-mediated injury; inappropriate Notch signalling may be a major contributor to failed regeneration within the lungs of patients with chronic lung disease.

Andrew E. Vaughan
Alexis N. Brumwell
Harold A. Chapman
Research24 Dec 2014
Nature

Volume: 517, P: 621-625
A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

Brian D. Kangas
Annabel K. Short
Diego A. Pizzagalli
Research17 Dec 2021
Neuropsychopharmacology

Volume: 47, P: 767-775
Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood

Laura M. Glynn
Hal S. Stern
Elysia P. Davis
Research23 Nov 2018
Neuropsychopharmacology

Volume: 44, P: 876-882
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia

Y Xi
Y Wei
H A Chapman
Research17 Dec 2012
Oncogene

Volume: 32, P: 5048-5057

Search

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5⁺ basal cells

Gli1⁺ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood

Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia

Search

Quick links

Search

Filter By:

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood

Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia

Search

Quick links

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5⁺ basal cells

Gli1⁺ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung