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Showing 1–6 of 6 results
Advanced filters: Author: Hanna Debiec Clear advanced filters

  • Considerable advances in our understanding of the molecular pathomechanisms of membranous nephropathy have been made over the past few years. In this Review, Ronco and Debiec provide an update on antigen–antibody systems involved in membranous nephropathies. The authors discuss experimental models that have helped elucidate systems involved in human disease, recent advances in this field as well as new therapies and future challenges.

    • Pierre Ronco
    • Hanna Debiec
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 203-213

  • Circulating anti-phospholipase A2 receptor (PLA2R) antibodies have been identified as an immunological marker of disease activity in patients with idiopathic membranous nephropathy. A simple assay has been developed to detect anti-PLA2R antibodies in serum. Now, we can monitor the response to drugs and adapt therapy in daily clinical practice.

    • Hanna Debiec
    • Pierre Ronco
    News & Views
    Nature Reviews Nephrology
    Volume: 7, P: 496-498

  • Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

    • Alexandra Barry
    • Michelle T. McNulty
    • Matthew G. Sampson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • By integrating discussion of responses to HLA and non-HLA donor antigens in transplantation, and fetomaternal microchimerism, Pierre Ronco and colleagues have produced a clear and concise overview of alloimmune processes underlying nephropathy of both grafted and native kidneys. The article describes the authors' discovery of a novel form of alloimmunization which causes congenital embranous nephropathy—transfer of antibodies against neutral endopeptidase from mother to fetus.

    • Pierre Ronco
    • Hanna Debiec
    • Vincent Guigonis
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 2, P: 388-397

  • Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

    • Jingyuan Xie
    • Lili Liu
    • Krzysztof Kiryluk
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Membranous nephropathy is a glomerular disease that is the most frequent cause of nephrotic syndrome in adults. This Primer reviews the epidemiology, pathophysiology, diagnosis and management of this disease and discusses how to improve long-term renal prognosis and quality of life.

    • Pierre Ronco
    • Laurence Beck
    • Jack Wetzels
    Reviews
    Nature Reviews Disease Primers
    Volume: 7, P: 1-23