Most neuropeptides target G-protein-coupled receptors. Now, it has been shown that the tetrapeptide FMRFamide can directly bind and activate a type of ion channel called FMRFamide-activated sodium channels (FaNaCs). This study reports the structure of the FaNaC ion channel in the apo and FMRFamide-bound states and the substrate specificity and possible gating mechanism of FaNaCs.
- Fenglian Liu
- Yu Dang
- Qingfeng Chen
