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Showing 1–3 of 3 results
Advanced filters: Author: Heimo Rainer Clear advanced filters

  • Data suggest an inverse relationship exists between where plant diversity occurs in nature and where it is housed. This disparity persists across physical and digital botanical collections despite overt colonialism ending over half a century ago.

    • Daniel S. Park
    • Xiao Feng
    • Charles C. Davis
    Research
    Nature Human Behaviour
    Volume: 7, P: 1059-1068

  • The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of  failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice and show that upregulation of funny current to the levels observed in human heart failure alters calcium homeostasis leading to cardiac remodelling and arrhythmia.

    • Pessah Yampolsky
    • Michael Koenen
    • Patrick A. Schweizer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Although the precipitating mechanisms of atrial fibrillation are not fully understood, atrial fibrosis is thought to set the stage for arrhythmia. Volker Rudolph et al. now show that the enzyme myeloperoxidase, released by inflammatory cells, is a key inducer of atrial fibrosis and arrhythmia in a mouse model of atrial fibrillation, and that myeloperoxidase levels are associated with atrial fibrillation in humans.

    • Volker Rudolph
    • René P Andrié
    • Stephan Baldus
    Research
    Nature Medicine
    Volume: 16, P: 470-474