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Showing 1–6 of 6 results
Advanced filters: Author: Hein Schepers Clear advanced filters

  • A series of genetic studies have led to the discovery of novel independent loci and candidate genes associated with red blood cell phenotype; for a proportion of these genes potential single-nucleotide genetic variants are also identified, providing new insights into genetic pathways controlling red blood cell formation, function and pathology.

    • Pim van der Harst
    • Weihua Zhang
    • John C. Chambers
    Research
    Nature
    Volume: 492, P: 369-375

  • Several important changes in disease classification and improvements in the management of patients with acute pancreatitis have been achieved in the past few years. This Review provides an overview of these changes, the effect on patient management and outcome, and outlines their scientific basis.

    • Olaf J. Bakker
    • Yama Issa
    • Hein G. Gooszen
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 462-469

  • CDC7 inhibition selectively induces senescence in hepatocellular carcinoma cells with TP53 mutations, which enables the selective apoptotic cell death of these senescent cells using inhibitors of mTOR signalling.

    • Cun Wang
    • Serena Vegna
    • René Bernards
    Research
    Nature
    Volume: 574, P: 268-272

  • The goals of treatment of chronic pancreatitis can roughly be divided into three categories: pain management, prevention and management of complications of pancreatitis, and correction of pancreatic insufficiency. In this Review, the authors discuss the merits and drawbacks of various treatment modalities for chronic pancreatitis, with a focus on management of pain.

    • Yama Issa
    • Marco J. Bruno
    • Marja A. Boermeester
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 556-564