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Showing 1–50 of 71 results

Advanced filters: Author: Helena Castro Clear advanced filters

Frequency of TERT promoter mutations in human cancers

Reactivation of telomerase has been implicated in human tumorigenesis. Here, somatic mutations in the TERT promoter are reported in cancers of the central nervous system, bladder, follicular cell-derived thyroid and melanoma, thus demonstrating that TERTpromoter mutations are a frequent event in human cancer.

João Vinagre
Ana Almeida
Paula Soares
Research26 Jul 2013
Nature Communications

Volume: 4, P: 1-6
Annelid adult cell type diversity and their pluripotent cellular origins

The cellular atlas of Pristina leidyi reveals cell type diversity in adult annelids by single cell transcriptomics, discovering several novel cell types and suggesting a pluripotent stem cell signature associated with adult cell type differentiation

Patricia Álvarez-Campos
Helena García-Castro
Jordi Solana
ResearchOpen Access12 Apr 2024
Nature Communications

Volume: 15, P: 1-22
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality

Here they generate a cell type atlas of the colonial cnidarian Hydractinia symbiolongicarpus, which reveals that distinct colony parts are mostly made from unique combinations of shared cell types, and identify novel cell types involved in biomineralization, and self/non-self recognition.

David A. Salamanca-Díaz
Helen R. Horkan
Jordi Solana
ResearchOpen Access03 Mar 2025
Nature Communications

Volume: 16, P: 1-20
Unforeseen plant phenotypic diversity in a dry and grazed world

Analysis of 20 chemical and morphological plant traits at diverse sites across 6 continents shows that the transition from semi-arid to arid zones is associated with an unexpected 88% increase in trait diversity.

Nicolas Gross
Fernando T. Maestre
Yoann Le Bagousse-Pinguet
Research07 Aug 2024
Nature

Volume: 632, P: 808-814
Reported ultra-low lava viscosities from the 2021 La Palma eruption are potentially biased

Guillem Gisbert
Valentin R. Troll
Juan Carlos Carracedo
ResearchOpen Access16 Oct 2023
Nature Communications

Volume: 14, P: 1-6
Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

Chikungunya virus is endemic in Brazil and cases have been rapidly increasing in recent years. Here, the authors describe the expansion of a genomic surveillance program across the country allowing them to characterise the emergence and dispersal of two distinct subclades mainly seeded from the north eastern region.

Joilson Xavier
Luiz Carlos Junior Alcantara
Marta Giovanetti
ResearchOpen Access21 Jul 2023
Nature Communications

Volume: 14, P: 1-12
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
COVID-19: don’t forget deaf people

Helena Carla Castro
Alex Sandro Lins Ramos
Norman Arthur Ratcliffe
Correspondence17 Mar 2020
Nature

Volume: 579, P: 343
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 306-319
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
The genetic legacy of the expansion of Bantu-speaking peoples in Africa

We gathered genetic data for 1,763 individuals from 147 populations across 14 African countries, and 12 Late Iron Age individuals, to trace the expansion of Bantu-speaking peoples over the past 6,000 years.

Cesar A. Fortes-Lima
Concetta Burgarella
Carina M. Schlebusch
ResearchOpen Access29 Nov 2023
Nature

Volume: 625, P: 540-547
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Oligoclonal mixtures of neutralising antibodies can target multiple antigen components and represent a potential therapeutic solution for the treatment of envenomation. Here, the authors generate mixtures of nanobodies against coral snake venom toxins and demonstrate they can prevent lethality of coral snake venoms in pre-clinical animal models.

Melisa Benard-Valle
Yessica Wouters
Andreas Hougaard Laustsen
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-13
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthetase, demonstrating on-target mechanism of action and efficacy in vivo.

Simon R. Green
Susan H. Davis
Laura A. T. Cleghorn
ResearchOpen Access11 Oct 2022
Nature Communications

Volume: 13, P: 1-12
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences.

Kaisa Thorell
Zilia Y. Muñoz-Ramírez
Charles S. Rabkin
ResearchOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1-16
Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000–2018

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

Natalia V. Bhattacharjee
Lauren E. Schaeffer
Simon I. Hay
ResearchOpen Access03 Jun 2021
Nature Human Behaviour

Volume: 5, P: 1027-1045
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Becher et al. perform a head-to-head comparison of multiple severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) vaccine prime-boost combinations and analyze the ensuing humoral and cellular responses in a large randomized cohort.

Nicolás Gonzalo Nuñez
Jonas Schmid
Burkhard Becher
ResearchOpen Access24 Apr 2023
Nature Immunology

Volume: 24, P: 941-954
Advancing the global public health agenda for NAFLD: a consensus statement

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease with a substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts develop consensus statements and recommendations addressing a broad range of topics on NAFLD to raise awareness and spur action.

Jeffrey V. Lazarus
Henry E. Mark
Ming-Hua Zheng
Reviews27 Oct 2021
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 60-78
StrongKids for pediatric nutritional risk screening in Brazil: a validation study

Carolina Araújo dos Santos
Carla de Oliveira Barbosa Rosa
Andréia Queiroz Ribeiro
Research05 May 2020
European Journal of Clinical Nutrition

Volume: 74, P: 1299-1305
Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.

Heike Stein
Joao Barbosa
Albert Compte
ResearchOpen Access25 Aug 2020
Nature Communications

Volume: 11, P: 1-11
Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography

Functional imaging of proteolytic activity is an emerging strategy to guide patient diagnosis and monitor clinical outcome. Here the authors present a peptide-based probe to detect and localize thrombin activity ex vivoand non-invasively in mouse models of wounding and pulmonary thrombosis.

Michael J. Page
André L. Lourenço
Charles S. Craik
ResearchOpen Access01 Oct 2015
Nature Communications

Volume: 6, P: 1-11
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil

Emerging variants of SARS-CoV-2 raise concerns about vaccine efficiency. Here, the authors present a post-hoc analysis for the ChAdOx1 nCoV-19 (AZD1222) vaccine trial in Brazil and provide efficacy against symptomatic COVID-19 caused by the Zeta (P.2) and other variants.

Sue Ann Costa Clemens
Pedro M. Folegatti
Rafael Zimmer
ResearchOpen Access06 Oct 2021
Nature Communications

Volume: 12, P: 1-10
PolLimCrop, a global dataset of pollen limitation in crops

Catarina Siopa
Helena Castro
Sílvia Castro
ResearchOpen Access15 Dec 2023
Scientific Data

Volume: 10, P: 1-7
Differential cytokine network profile in polycythemia vera and secondary polycythemia

Maira da Costa Cacemiro
Juçara Gastaldi Cominal
Fabíola Attié de Castro
ResearchOpen Access27 Apr 2020
Scientific Reports

Volume: 10, P: 1-7
Streptomyces qaidamensis sp. nov., isolated from sand in the Qaidam Basin, China

Binglin Zhang
Shukun Tang
Paul Dyson
Research19 Jul 2018
The Journal of Antibiotics

Volume: 71, P: 880-886
Chaperone activation and client binding of a 2-cysteine peroxiredoxin

Many 2-Cystein Peroxiredoxins (Prx) can either function as peroxidases or chaperones when exposed to stress. Here the authors present the structures of Leishmania infantum mitochondrial Prx alone and with a bound model client protein, use crosslinking to reveal interaction regions that stabilize the bound client, and provide insights into the mechanism by which Prx’s adopt chaperone activity.

Filipa Teixeira
Eric Tse
Ursula Jakob
ResearchOpen Access08 Feb 2019
Nature Communications

Volume: 10, P: 1-14
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Modelling the effect of defects and cracks in solar cells’ performance using the d1MxP discrete model

Ricardo A. Marques Lameirinhas
Catarina P. Correia V. Bernardo
Pedro Mendonça dos Santos
ResearchOpen Access01 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
A tiered strategy to identify relevant genetic variants in familial pulmonary fibrosis: a proof of concept for the clinical practice

Aitana Alonso-González
Ibrahim Véliz-Flores
Carlos Flores
ResearchOpen Access02 Jan 2025
European Journal of Human Genetics

P: 1-11
Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012–2015)

Catarina Silva-Costa
Maria J. Brito
Isabel Monteiro
ResearchOpen Access09 Jan 2019
Scientific Reports

Volume: 9, P: 1-9
Beyond comorbidities, sex and age have no effect on COVID-19 health care demand

Jorge M. Mendes
Helena Baptista
Miguel de Castro Neto
ResearchOpen Access05 May 2022
Scientific Reports

Volume: 12, P: 1-12
Potential and limitations of machine meta-learning (ensemble) methods for predicting COVID-19 mortality in a large inhospital Brazilian dataset

Bruno Barbosa Miranda de Paiva
Polianna Delfino Pereira
Milena Soriano Marcolino
ResearchOpen Access01 Mar 2023
Scientific Reports

Volume: 13, P: 1-18
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Solid-state fermented brewer's spent grain enzymatic extract increases in vitro and in vivo feed digestibility in European seabass

Helena Fernandes
Francisco Moyano
Helena Peres
ResearchOpen Access25 Nov 2021
Scientific Reports

Volume: 11, P: 1-15
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress

Átila Duque Rossi
João Locke Ferreira de Araújo
Cynthia Chester Cardoso
ResearchOpen Access06 May 2021
Scientific Reports

Volume: 11, P: 1-9
Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes

Israel Molina
Milena Soriano Marcolino
Maria do Carmo Pereira Nunes
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
Bacterial and Symbiodiniaceae communities’ variation in corals with distinct traits and geographical distribution

Livia Bonetti Villela
Arthur Weiss da Silva-Lima
Paulo Sergio Salomon
ResearchOpen Access16 Oct 2024
Scientific Reports

Volume: 14, P: 1-17
Unlocking the complete blood count as a risk stratification tool for breast cancer using machine learning: a large scale retrospective study

Daniella Castro Araujo
Bruno Aragão Rocha
Ismael Dale Cotrim Guerreiro da Silva
ResearchOpen Access12 May 2024
Scientific Reports

Volume: 14, P: 1-10
Changes in emm types and superantigen gene content of Streptococcus pyogenes causing invasive infections in Portugal

A. Friães
J. Melo-Cristino
Natália Novais
ResearchOpen Access02 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Relatedness-based mate choice and female philopatry: inbreeding trends of wolf packs in a human-dominated landscape

Carolina Pacheco
Helena Rio-Maior
Raquel Godinho
ResearchOpen Access12 Mar 2024
Heredity

Volume: 132, P: 211-220
Parental segregation study reveals rare benign and likely benign variants in a Brazilian cohort of rare diseases

Caio Robledo D.’Angioli Costa Quaio
Jose Ricardo Magliocco Ceroni
Chong Ae Kim
ResearchOpen Access11 May 2022
Scientific Reports

Volume: 12, P: 1-9
Antibiofilm effects of N,O-acetals derived from 2-amino-1,4-naphthoquinone are associated with downregulation of important global virulence regulators in methicillin-resistant Staphylococcus aureus

Juliana Silva Novais
Mariana Fernandes Carvalho
Agnes Marie Sá Figueiredo
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-13
Erratum: miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice

Pedro M Rodrigues
Marta B Afonso
Rui E Castro
Amendments and CorrectionsOpen Access25 May 2017
Cell Death & Disease

Volume: 8, P: e2825

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