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Showing 1–15 of 15 results
Advanced filters: Author: Henrik Scheller Clear advanced filters

  • QS-21—an FDA-approved vaccine adjuvant—and several structural analogues of QS-21 can be synthesized in engineered yeast strains, and this process is much less laborious compared with the conventional mode of extraction from the Chilean soapbark tree.

    • Yuzhong Liu
    • Xixi Zhao
    • Jay D. Keasling
    ResearchOpen Access
    Nature
    Volume: 629, P: 937-944

  • Plant cell walls incorporate a variety of acetylated polysaccharides. In addition to enzymes catalysing acetylation (acetyltransferases), plants could produce enzymes to remove acetyl groups (acetylesterases). Previously, pectin acetylesterases were known and now a xylan acetylesterase has been identified — and it has many surprises.

    • Henrik V. Scheller
    News & Views
    Nature Plants
    Volume: 3, P: 1-2

  • Methyl jasmonate triggers saponin production in Saponaria vaccaria. Using transcriptome data and heterologous expression, the authors identify P450s and glycosyltransferases that modify triterpenoids. They also discover the pathway for UDP-D-fucose biosynthesis.

    • Xiaoyue Chen
    • Graham A. Hudson
    • Henrik V. Scheller
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Hydroxyglutarate synthase (HglS) converts 2-oxoadipate to D-2- hydroxyglutarate during lysine catabolism in bacteria. Here the authors use structural and biochemical approaches to show that HglS acts via successive decarboxylation and intramolecular hydroxylation and that homologous enzymes catalyze the final step of lysine catabolism in plants.

    • Mitchell G. Thompson
    • Jacquelyn M. Blake-Hedges
    • Jay D. Keasling
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Engineering of yeast transcription factors and design of hybrid DNA promoter elements have resulted in a toolkit for tunable and orthogonal regulation of gene expression in Arabidopsis thaliana and Nicotiana benthamiana plants.

    • Michael S. Belcher
    • Khanh M. Vuu
    • Patrick M. Shih
    Research
    Nature Chemical Biology
    Volume: 16, P: 857-865

  • Nucleotide sugars are transported from the cytoplasm to the Golgi lumen where they are incorporated into cell wall polysaccharides and used for glycosylation of proteins and lipids. Here the authors identify GFT1, an ArabidopsisGolgi-localized GDP-fucose transporter that is required for plant growth and development

    • Carsten Rautengarten
    • Berit Ebert
    • Joshua L. Heazlewood
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Cell walls made mainly of polysaccharides are a distinguishing feature of plants. They play key roles in adaptation today and during pivotal evolutionary events, such as colonization of dry land and development of a water-conducting vascular system. A critical enzyme involved in cell wall biosynthesis has now been identified.

    • Peter Ulvskov
    • Henrik V. Scheller
    News & Views
    Nature Plants
    Volume: 4, P: 635-636

  • N-linked glycosylation is processed in the endoplasmic reticulum and Golgi for eukaryotic proteins. Now, a single Golgi-localized UDP-N-acetyl-d-glucosamine transporter was identified to be essential for the processing of protein N-glycosylation and the synthesis of GlcNAc-containing sphingolipids.

    • Berit Ebert
    • Carsten Rautengarten
    • Joshua L. Heazlewood
    Research
    Nature Plants
    Volume: 4, P: 792-801

  • Production of aromatic monoterpene molecules in hop flowers is affected by genetic, environmental, and processing factors. Here, the authors engineer brewer’s yeast for the production of linalool and geraniol, and show pilot-scale beer produced by engineered strains reconstitutes some qualities of hop flavor.

    • Charles M. Denby
    • Rachel A. Li
    • Jay D. Keasling
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • The genome of the wild grass Brachypodium distachyon (Brachypodium), a member of the Pooideae subfamily, is sequenced. The Pooideae are one of three subfamilies of grasses that provide the bulk of human nutrition and may become major sources of renewable energy. Availability of the genome sequence should help establish Brachypodium as a model for developing new energy and food crops.

    • John P. Vogel
    • David F. Garvin
    • Ivan Baxter
    Research
    Nature
    Volume: 463, P: 763-768