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Showing 1–50 of 105 results

Advanced filters: Author: Hiroyuki Yasuda Clear advanced filters

Plasma Polymerization of Hexamethyldisilazane

Soo Young Park
Nakjoong Kim
Hiroyuki Sasabe
Research01 Mar 1990
Polymer Journal

Volume: 22, P: 242-249
Synthesis and Biodegradability of Copolymers of Ethylene Carbonate with Lactones

Hiroyuki Shirahama
Akinori Kanetani
Hajime Yasuda
Research01 Mar 2000
Polymer Journal

Volume: 32, P: 280-286
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma

Resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) is prevalent. Here the authors establish a biobank of patient-derived EGFR-mutant lung cancer organoids and identify a subgroup of EGFR-TKI-resistant lung adenocarcinoma organoids, which exhibit a basal-shift phenotype and vulnerability to CDK4/6 inhibitors.

Taro Shinozaki
Kazuhiro Togasaki
Toshiro Sato
ResearchOpen Access11 May 2025
Nature Communications

Volume: 16, P: 1-15
Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells

Atsuho Morita
Makoto Ishii
Koichi Fukunaga
ResearchOpen Access23 Jun 2025
npj Regenerative Medicine

Volume: 10, P: 1-16
Stabilization of Enzyme Activity by an Organic Solvent

SHIGEKI TAKEMORI
EISUKE FURUYA
MASAYUKI KATAGIRI
Research22 Jul 1967
Nature

Volume: 215, P: 417-419
A protein language model for exploring viral fitness landscapes

Ito et al. present CoVFit, an AI model that predicts variant fitness (transmissibility) from spike protein sequences alone. They further demonstrate its utility in forecasting viral evolution via single amino acid mutations.

Jumpei Ito
Adam Strange
Kei Sato
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-16
Highly coupled ATP synthesis by F₁-ATPase single molecules

Yannick Rondelez
Guillaume Tresset
Hiroyuki Noji
Research17 Feb 2005
Nature

Volume: 433, P: 773-777
An organoid library unveils subtype-specific IGF-1 dependency via a YAP–AP1 axis in human small cell lung cancer

Sato and colleagues present a biobank of patient-derived SCLC organoids, conducting a comprehensive genome and transcriptome profiling that reveals the existence of NE and non-NE subtypes with distinct molecular dependencies.

Takahiro Fukushima
Kazuhiro Togasaki
Toshiro Sato
Research30 Apr 2025
Nature Cancer

Volume: 6, P: 874-891
Ethylene Polymerization with Silica-Supported Cr[N(SiMe₃)₂]₃/Alumoxane Catalyst

Takashi Monoi
Haruhiko Ikeda
Yasuaki Sasaki
Research01 Jun 2002
Polymer Journal

Volume: 34, P: 461-465
Direct observation of the rotation of F₁-ATPase

Hiroyuki Noji
Ryohei Yasuda
Kazuhiko Kinosita Jr
Research20 Mar 1997
Nature

Volume: 386, P: 299-302
Correction: Corrigendum: Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults

Takahiko Yasuda
Shinobu Tsuzuki
Hiroyuki Mano
Amendments and Corrections29 Nov 2016
Nature Genetics

Volume: 48, P: 1591
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults

Hiroyuki Mano and colleagues report fusions involving DUX4 in 16.4% of Ph-negative adolescent and young adult acute lymphoblastic leukemia (AYA-ALL) cases. Transplantation assays in mice support an oncogenic role for the DUX4-IGH fusion gene, which expresses DUX4 protein with an aberrant C terminus at high levels in patients with AYA-ALL.

Takahiko Yasuda
Shinobu Tsuzuki
Hiroyuki Mano
Research28 Mar 2016
Nature Genetics

Volume: 48, P: 569-574
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Hiroyuki Tamemoto
Takashi Kadowaki
Shinichi Aizawa
Research10 Nov 1994
Nature

Volume: 372, P: 182-186
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Synthesis of Poly(methyl methacrylate) Microspheres Bearing Phosphatidylcholine Analogous and Azobenzene Moieties

Kazuo Sugiyama
Kohei Shiraishi
Hajime Yasuda
Research01 May 1993
Polymer Journal

Volume: 25, P: 521-527
Pediatric Tumor Cells Express Erythropoietin and a Functional Erythropoietin Receptor that Promotes Angiogenesis and Tumor Cell Survival

Sandeep Batra
Natalya Perelman
Punam Malik
Research01 Oct 2003
Laboratory Investigation

Volume: 83, P: 1477-1487
Dominance in self-compatibility between subgenomes of allopolyploid Arabidopsis kamchatica shown by transgenic restoration of self-incompatibility

Self-incompatibility in diploid Arabidopsis relatives is determined by a dominance relationship that is epigenetically regulated. Using transgenic methods, this study demonstrates that the dominance relationship between subgenomes of the allopolyploid species Arabidopsis kamchatica underlies it’s self-compatibility.

Chow-Lih Yew
Takashi Tsuchimatsu
Kentaro K. Shimizu
ResearchOpen Access29 Nov 2023
Nature Communications

Volume: 14, P: 1-11
Mechanically driven ATP synthesis by F₁-ATPase

Hiroyasu Itoh
Akira Takahashi
Kazuhiko Kinosita Jr
Research29 Jan 2004
Nature

Volume: 427, P: 465-468
Occult endocrine disorders newly diagnosed in patients with post-COVID-19 symptoms

Yasuhiro Nakano
Naruhiko Sunada
Fumio Otsuka
ResearchOpen Access05 Mar 2024
Scientific Reports

Volume: 14, P: 1-7
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Structural basis for receptor-binding ___domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Hisano Yajima
Yuki Anraku
Takao Hashiguchi
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex

Tuberous sclerosis complex (TSC) arises from mutations in an activator of the small GTPase Rheb. Here the authors show that syntenin binds to GDP-bound Rheb, and loss of this interaction in TSC leads to increased syntenin expression and downstream signalling defects leading to aberrant spine synapse morphogenesis.

Hiroko Sugiura
Shin Yasuda
Kanato Yamagata
Research16 Apr 2015
Nature Communications

Volume: 6, P: 1-15
Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels

A double-network hydrogel can rapidly reprogramme differentiated tumour cells into cancer stem cells that display elevated tumorigenicity in vivo.

Jun Suzuka
Masumi Tsuda
Shinya Tanaka
Research29 Mar 2021
Nature Biomedical Engineering

Volume: 5, P: 914-925
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

This study identifies TTTCA- and TTTTA-repeat expansions in benign adult familial myoclonic epilepsy. Cortical neurons from affected people exhibit RNA foci containing these expanded repeats, suggesting RNA toxicity as the mechanism underlying disease pathogenesis.

Hiroyuki Ishiura
Koichiro Doi
Shoji Tsuji
Research05 Mar 2018
Nature Genetics

Volume: 50, P: 581-590
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Masato Kasuga and colleagues and Shiro Maeda and colleagues each report the independent identification of SNPs in KCNQ1 associated with type 2 diabetes in the Japanese population. Each group replicated the associations in other populations of East Asian and European descent.

Kazuki Yasuda
Kazuaki Miyake
Masato Kasuga
Research17 Aug 2008
Nature Genetics

Volume: 40, P: 1092-1097
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis

How β-AR signaling coordinates epigenetic and transcriptional pathways is unknown. Here the authors show that cold-induced β-AR signaling negatively regulates MYPT1-PP1β phosphatase activity to orchestrate both pathways for beige adipogenesis.

Hiroki Takahashi
Ge Yang
Juro Sakai
ResearchOpen Access29 Sept 2022
Nature Communications

Volume: 13, P: 1-19
High-efficiency organic light-emitting diodes with fluorescent emitters

Fluorescent organic light-emitting diodes hold promise for next-generation full-colour displays, but are currently limited by the internal electroluminescence quantum efficiency. Nakanotani et al.break this limit and demonstrate nearly 100% efficiency in a double-dopant system without a rare metal.

Hajime Nakanotani
Takahiro Higuchi
Chihaya Adachi
Research30 May 2014
Nature Communications

Volume: 5, P: 1-7
Mutations in the hepatocyte nuclear factor-1α gene (MODY3) are not a major cause of early-onset non-insulin-dependent (type 2) diabetes mellitus in Japanese

Hidekazu Nishigori
Shirou Yamada
J. Takeda
Research01 Jun 1998
Journal of Human Genetics

Volume: 43, P: 107-110
Conformations of 24-Membered Ring Pseudopeptides Containing N,N′-Ethylene-Bridged Dipeptides Constructed from (S)-Alanine, -Leucine, -Isoleucine, and -Phenylalanine

Yoshitane Kojima
Hisayo Goto
Tetsushi Yamashita
Research01 Mar 1994
Polymer Journal

Volume: 26, P: 257-265
High Oxygen Permeation and Persistent Oxygen-Carrying in a Poly(vinylimidazole-co-fluoroalkyl methacrylate)-Cobaltporphyrin Membrane

Baoqing Shentu
Hiromi Shinohara
Hiroyuki Nishide
Research01 Oct 2001
Polymer Journal

Volume: 33, P: 807-811
Cooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin in microspike formation

Wataru Ikeda
Hiroyuki Nakanishi
Yoshimi Takai
Research27 Jun 2001
Oncogene

Volume: 20, P: 3457-3463
Microfabricated arrays of femtoliter chambers allow single molecule enzymology

Yannick Rondelez
Guillaume Tresset
Hiroyuki Noji
Research20 Feb 2005
Nature Biotechnology

Volume: 23, P: 361-365
Identification of a radical SAM enzyme involved in the synthesis of archaeosine

Euryarchaeal ArcS alone cannot produce G⁺-containing tRNA but works as a lysine transferase to produce a lysine adduct intermediate, which finally forms G⁺-containing tRNA in the presence of a newly identified SAM enzyme, RaSEA.

Takashi Yokogawa
Yuichiro Nomura
Satoshi Ohno
Research18 Nov 2019
Nature Chemical Biology

Volume: 15, P: 1148-1155
Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

Expression of Cas9 and gRNA from viral vectors in vivo may cause off-target activity. Here the authors present NanoMEDIC, which uses nanovesicles to transiently deliver editing machinery to hard-to-transfect cells.

Peter Gee
Mandy S. Y. Lung
Akitsu Hotta
ResearchOpen Access13 Mar 2020
Nature Communications

Volume: 11, P: 1-18
Serum syndecan-1 reflects organ dysfunction in critically ill patients

Keiko Suzuki
Hideshi Okada
Akio Suzuki
ResearchOpen Access23 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Presence of sarcopenia does not affect the clinical results of balloon kyphoplasty for acute osteoporotic vertebral fracture

Shoichiro Ohyama
Masatoshi Hoshino
Hiroaki Nakamura
ResearchOpen Access08 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
Resolution of distinct rotational substeps by submillisecond kinetic analysis of F₁-ATPase

Ryohei Yasuda
Hiroyuki Noji
Hiroyasu Itoh
Research19 Apr 2001
Nature

Volume: 410, P: 898-904
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures

The transmembrane protein Elfn1 is implicated in synaptic plasticity. Tomioka et al. identify Elfn1 mutations in epilepsy and attention deficit hyperactivity disorder (ADHD) patients, and show that loss of Elfn1in mice results in seizures, ADHD-like behaviour and impaired development of excitatory synapses.

Naoko H. Tomioka
Hiroki Yasuda
Jun Aruga
Research22 Jul 2014
Nature Communications

Volume: 5, P: 1-16
Small-RNA asymmetry is directly driven by mammalian Argonautes

Asymmetric selection of single-stranded guide RNAs from double-stranded RNA precursors is determined by Ago2, which detects 5′-nucleotide identity and thermodynamic stability of microRNA duplex ends via its MID ___domain.

Hiroshi I Suzuki
Akihiro Katsura
Kohei Miyazono
Research22 Jun 2015
Nature Structural & Molecular Biology

Volume: 22, P: 512-521
X-ray pumping of the ²²⁹Th nuclear clock isomer

Excitation to the second excited state of ²²⁹Th is used to populate the metastable state ^229mTh, enabling accurate determination of the isomer’s energy, half-life and excitation linewidth.

Takahiko Masuda
Akihiro Yoshimi
Koji Yoshimura
Research11 Sept 2019
Nature

Volume: 573, P: 238-242
Characteristic radiological findings for revision surgery after balloon kyphoplasty

Shinji Takahashi
Masatoshi Hoshino
Hiroaki Nakamura
ResearchOpen Access06 Dec 2019
Scientific Reports

Volume: 9, P: 1-7
Destruction of tumor mass by gadolinium-loaded nanoparticles irradiated with monochromatic X-rays: Implications for the Auger therapy

Kotaro Matsumoto
Hiroyuki Saitoh
Fuyuhiko Tamanoi
ResearchOpen Access30 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.

Tomokazu Tamura
Jumpei Ito
Kei Sato
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-20
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Recent Omicron SARS-CoV-2 subvariants independently acquire 5 key Spike mutations. Here, the authors evaluate the evolutionary importance of the 5 mutations and characterize the virological properties of variant BQ.1.1 harboring all 5 mutations.

Jumpei Ito
Rigel Suzuki
Kei Sato
ResearchOpen Access11 May 2023
Nature Communications

Volume: 14, P: 1-20
Cup-Shaped Superparamagnetic Hemispheres for Size-Selective Cell Filtration

Hyonchol Kim
Hideyuki Terazono
Kenji Yasuda
ResearchOpen Access15 Sept 2014
Scientific Reports

Volume: 4, P: 1-6
Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

Besides hepatocytes, resident immune cells of the liver are also contributing to the body’s energy homeostasis. Here authors show that group 2 innate lymphoid cells interact with a specific set of hepatocytes in suppressing gluconeogenesis and regulate blood glucose levels via Interleukin-13 signalling.

Masanori Fujimoto
Masataka Yokoyama
Tomoaki Tanaka
ResearchOpen Access15 Sept 2022
Nature Communications

Volume: 13, P: 1-21
Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas

Hiroyuki Kon
Yukihiko Sonoda
Yoshinori Murakami
Research23 Jan 1998
Oncogene

Volume: 16, P: 257-263
Nifedipine-Induced Vascular Endothelial Growth Factor Secretion from Coronary Smooth Muscle Cells Promotes Endothelial Tube Formation via the Kinase Insert Domain-Containing Receptor/Fetal Liver Kinase-1/NO Pathway

Shin-ichiro Miura
Masahiro Fujino
Keijiro Saku
Research01 Feb 2005
Hypertension Research

Volume: 28, P: 147-153
Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction

Slit and NTRK-like family member (Slitrk) proteins are known to have typical peptide signatures for synaptogenic cell adhesion. This study reveals a specific function of Slitrk3 and tyrosine phosphatase receptor PTPδ transynaptic interaction in inhibitory synaptogenesis and excitatory and inhibitory balance.

Hideto Takahashi
Kei-ichi Katayama
Ann Marie Craig
Research29 Jan 2012
Nature Neuroscience

Volume: 15, P: 389-398

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