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Ionic or molecular transport in conventional polymeric membranes often suffers from a trade-off between permeability and selectivity. The authors report on an interfacial polymer cross-linking strategy to produce a robust, permeable and selective 3-µm-thick ultrathin polymeric membrane containing quasi-ordered reticular cross-linking structures.

Natural vesicles typically consist of a lipid membrane enclosing substances. Now a coacervate vesicle formed by liquid–liquid phase separation of cholesterol-modified DNA and histones has been developed. Unlike traditional vesicles, these lack a membrane and feature a high-density liquid layer around a water-filled cavity, offering enhanced kinetic stability and potential as a biopharmaceutical delivery system.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Intricate regulation of gene expression is important for execution of biology processes. Here, the authors generate a comprehensive map of accessible chromatin by integrating the ATAC-seq data of 12 major maize tissues and explore their interspecific and intraspecific constraints in multiple Poaceae and maize genomes.

The authors describe a new mechanism of AD pathogenesis in which the histone methylase G9a regulates translation of hippocampal proteins associated with AD pathology. Targeting this mechanism with a brain-penetrant inhibitor of G9a helped rescue brain pathology in AD mouse models.

Monolayers of transition metal dichalcogenides have many of the properties required for applications in spintronics and valleytronics. Here, the authors experimentally observe intervalley quantum interference involving conduction band Q-valleys in tungsten diselenide.

Rooftop photovoltaic systems are often seen as a niche solution for mitigation but could offer large-scale opportunities. Using multi-source geospatial data and artificial intelligence techniques, the authors map their potential for reducing global temperatures and analyse regional differences.

The controlled in situ formation of biomolecular condensates as intracellular reservoirs for the enrichment and retention of a chemotherapeutic in cancer cells enhanced antitumour activities in mice with drug-resistant tumours.

Recently, significant progress has been made in higher harmonic generation of spin waves in magnetic materials, but it remains challenging to probe the coherence. Here, Lan, Liu et al observe the higher-harmonic spin-wave generation induced by static edge spin textures in a soft ferromagnetic film, and probe the coherence of higher harmonic generation.

Atherosclerosis is associated with the dysregulation of lipid metabolism in vascular endothelial cells. Here, the authors show that the accumulation of lipid droplets in vascular endothelial cells disrupts endothelial ciliation and contributes to atherosclerosis by reducing cytosolic palmitic acid.

Defect engineering in catalysts can enhance performance by manipulating vacancy configurations, but controlling them is challenging. The authors report triple O-Ti-O vacancies in Ni-doped TiO₂, which boost catalytic reactions through water dissociation and active site regeneration.

Bimetallic zinc and gold porphyrin self-assembled into 2D nanosheets as nanoscale optoelectrodes. This design achieves exceptional photoelectric performance under visible one-photon and near-infrared two-photon excitation, enabling far-field optical modulation of single neurons.

Plasmonic-enhanced nanosensors are limited in practical applications, as it remains challenging to detect molecules at low concentrations. Here, the authors introduce a buoyant particulate strategy in order to enrich analytes in the plasmonic hot spots.

Spin polarization in non-magnetic solids has mainly been limited to non-centrosymmetric materials. Here, the authors identify a helical spin texture in the centrosymmetric semiconductor platinum diselenide, and suggest it arises from a local dipole induced Rashba effect rather than the usual spin-splitting.

Implants made from patient-derived lyophilized lymph nodes loaded with chimeric antigen receptor T cells improve T cell delivery and inhibit tumour recurrence.

Criegee intermediates are pivotal in atmospheric chemistry, yet their cationic forms remain poorly understood. Here, the authors present infrared spectra of cationic Criegee intermediates, specifically syn- and anti-CH₃CHOO⁺, using vacuum ultraviolet photoionization coupled with IR photon dissociation spectroscopy.

Spin-orbit couplings enable the electrical manipulation of spin degrees of freedom and so have a central role in spintronic devices. Here, the authors identify an unconventional spin-orbit effect in high-symmetry situations that leads to a linear magnetoelectric coupling in reciprocal space.

A study identifies two genes that act as brakes controlling the sugar content of tomatoes and demonstrates their manipulation to generate sweeter tomatoes without affecting the fruit size and yield.

Novel methodologies for cleaving inherently inert C(sp²)‒ C(sp²) bonds are desirable. Here, the authors report the use of an oriented electric field to cleave C(sp²)‒ C(sp²) in cycloparaphenylenes via electrophilic aromatic substitution.

A portable multiplexed assay allows for the rapid detection, via plasmonic-gold-enhanced near-infrared fluorescence, of SARS-CoV-2 RNA at single-copy sensitivity and single-nucleotide specificity for the discrimination of variants of the virus.

Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined.

The origin of the charge density wave in vanadium antimonides has been widely debated. Here, the authors report the cooperation of electron-phonon and phonon-phonon coupling for the formation of the charge density wave in CsV₃Sb₅.

Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology of mental disorders; this approach was used with samples from a family with a schizophrenia pedigree and a DISC1 mutation, revealing synaptic abnormalities and large-scale transcriptional dysregulation.

Mice deficient in the Polycomb repressor Bmi1 have a shortened lifespan and develop numerous abnormalities including defects in stem cell self-renewal and thymocyte maturation. Here it is demonstrated that cells derived from Bmi1^−/− mice also show a marked elevation in the intracellular levels of reactive oxygen species, corresponding to the derepression of previously identified Polycomb target genes and sufficient to engage the DNA damage response pathway.

A machine learning framework is proposed to accurately predict electron–phonon coupling (EPC) strengths while reducing computational costs compared with first-principles methods. This approach facilitates EPC calculations with advanced functionals, allowing the accurate determination of real-world material properties such as carrier mobility and superconductivity.

Dorsal root ganglia (DRGs) contain a plethora of neuron types. The authors show that the existence of human-specific DRG neuronal types and microneurography recordings reveal distinct temperature-sensing properties across human sensory afferent types.

Enhanced expression of chloroplast elongation factors StTuA/B increases potato disease resistance and photosynthesis, while oomycete effector Pi22926 inhibits their entry into the chloroplasts by disrupting their phosphorylation by StMAP3Kβ2.

Adaptive differentiation is poorly understood in marine systems. Here, the authors combine genome sequencing with gene expression and physiology to show that genetic divergence and plasticity contribute to local adaptation of Pacific oyster populations.

Zhu and colleagues identify GREMLIN1 as an FGFR1 ligand that promotes plasticity and castration resistance in prostate cancer through regulation of MAPK signaling, and show that anti-GREMLIN1 antibody therapy synergizes with androgen deprivation.

Soil organisms are affected by the presence of predatory protists. Here, the authors predatory protists are negatively associated with bacteria wilt disease incidence in tomato plants and that fertilisation enhances the abundance of predatory protists

Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.

Genetic analyses of teosinte, the wild ancestor of maize, identify a locus (THP9) that is associated with high seed protein content and increased nitrogen-use efficiency, suggesting that THP9 could have applications in crop breeding.

Newly developed microfluidic neural tube-like and forebrain-like structures based on human pluripotent stem cells can model pivotal aspects of neural patterning along both the rostral–caudal and dorsal–ventral axes.

Kagome superconductors host a panoply of condensed matter phenomena, some of which are mediated by band topology. Here, authors use ARPES and DFT to identify type-II and type-III Dirac nodal lines, flat bands and topological surface states in the kagome metal CsTi₃Bi₅.

Structural and biochemical studies of the Notch O-glucosyltransferase Rumi in complex with its substrates inform on the catalytic mechanism for Rumi substrate recognition, and characterization of cancer mutations in Rumi reveals loss of enzyme activity.

Activation of the NLRP3 inflammasome triggers the production of inflammatory cytokines. Here, the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show that administration in mice is effective in preventing septic shock and peritonitis, and in improving diabetes-associated inflammation and insulin resistance.

The authors report selective nucleophilic α-C alkylation of phenols with alcohols catalyzed by anatase titanium dioxide. Experimental and computational studies reveal the formation of Ti=C_α intermediate with the primary carbon of alkyl group at oxygen vacancies of anatase titanium dioxide.

A high-throughput screen of preclinical, investigational and FDA-approved drugs identifies compounds that possess antiviral and neuroprotective effects against Zika virus infection in human neural progenitor cells and astrocytes.

Connecting the different layers in thermoelectric modules is challenging. Yin et al. develop a low-temperature-sintered silver nanoparticle interlayer for high-temperature operation of devices based on a variety of thermoelectric materials.

The design of highly selective yet robust anion exchange membranes remains a challenge. Here, the authors prepare a stable polymer membrane composed of terphenyl isomers, demonstrate roll-to-roll manufacturing, and assess its properties in redox flow batteries, water electrolyzers and fuel cells.