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Molecular Psychiatry (23)
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Showing 1–50 of 66 results

Advanced filters: Author: Howard Edenberg Clear advanced filters

Novobiocin inhibition of simian virus 40 DNA replication

Howard J. Edenberg
Research31 Jul 1980
Nature

Volume: 286, P: 529-531
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

P: 1-11
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Radiation hybrid mapping of genes in the lithium-sensitive Wnt signaling pathway

A R Rhoads
J D Karkera
S D Detera-Wadleigh
Research08 Oct 1999
Molecular Psychiatry

Volume: 4, P: 437-442
Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder

This multi-ancestral meta-analysis of alcohol use disorder in over one million individuals identifies genome-wide significant risk variants from independent genomic loci and shared genetic architecture between alcohol use disorder and other mental and general medical conditions.

Romain Icick
Alexey Shadrin
Ole A. Andreassen
Research08 Jan 2025
Nature Mental Health

Volume: 3, P: 253-265
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Using a sample of more than 1 million individuals, Hatoum et al. identify genomic loci associated with general and substance-specific addiction risk.

Alexander S. Hatoum
Sarah M. C. Colbert
Arpana Agrawal
Research22 Mar 2023
Nature Mental Health

Volume: 1, P: 210-223
Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Alcohol use disorder and drinks per week both have been studied genetically and have different correlations with psychiatric diseases. Here the authors integrate multi-omics data to identify unique and shared variants, genes and pathways for alcohol use disorder and drinks per week.

Manav Kapoor
Michael J. Chao
Alison Goate
ResearchOpen Access20 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

This paper identified >500 genetic loci associated with behaviors and disorders related to self-regulation, including addiction and child behavior problems. The resulting genetic risk scores predict several behavioral, medical and social outcomes.

Richard Karlsson Linnér
Travis T. Mallard
Danielle M. Dick
Research26 Aug 2021
Nature Neuroscience

Volume: 24, P: 1367-1376
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

A multi-ancestry genome-wide association study of problematic alcohol use in one million individuals identified 110 risk variants and shows that multi-ancestry polygenic scores improve risk prediction compared with single-ancestry scores

Hang Zhou
Rachel L. Kember
Joel Gelernter
ResearchOpen Access07 Dec 2023
Nature Medicine

Volume: 29, P: 3184-3192
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Richard Karlsson Linnér
Travis T. Mallard
Danielle M. Dick
Amendments and Corrections06 Dec 2024
Nature Neuroscience

Volume: 28, P: 213
CRF-Amplified Neuronal TLR4/MCP-1 Signaling Regulates Alcohol Self-Administration

Harry L June
Juan Liu
Laure Aurelian
Research08 Jan 2015
Neuropsychopharmacology

Volume: 40, P: 1549-1559
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

Multi-ancestry genome-wide association meta-analyses identify risk loci for cannabis use disorder. Genomic structural equation modeling and genetic correlation analyses show overlap with several other traits, including impulsivity and psychopathology.

Daniel F. Levey
Marco Galimberti
Joel Gelernter
ResearchOpen Access20 Nov 2023
Nature Genetics

Volume: 55, P: 2094-2103
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Genetics and alcoholism

Excessive consumption of alcohol can have serious physical, psychological and social implications. Alcohol dependence is a complex genetic disease, with variants in many different genes affecting a person's risk of becoming dependent on alcohol. Here, the authors discuss the genetic factors underlying this disorder.

Howard J. Edenberg
Tatiana Foroud
Reviews28 May 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 10, P: 487-494
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

A genetic study of problematic alcohol use in 435,563 individuals, including data from the Million Veteran Program, Psychiatric Genomics Consortium and UK Biobank, found many novel risk loci and provided new insights into trait biology.

Hang Zhou
Julia M. Sealock
Joel Gelernter
Research25 May 2020
Nature Neuroscience

Volume: 23, P: 809-818
Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples

Peter B. Barr
Albert Ksinan
Danielle M. Dick
ResearchOpen Access18 Jun 2020
Translational Psychiatry

Volume: 10, P: 1-9
Reply to “Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression”

Francis J McMahon
Nirmala Akula
Thomas G Schulze
Correspondence28 Dec 2010
Nature Genetics

Volume: 43, P: 5
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Renato Polimanti
Raymond K. Walters
Joel Gelernter
Research26 Feb 2020
Molecular Psychiatry

Volume: 25, P: 1673-1687
Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders

Xi Rao
Kriti S. Thapa
Yunlong Liu
ResearchOpen Access02 Sept 2019
Molecular Psychiatry

Volume: 26, P: 1142-1151
Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance

Jacquelyn L. Meyers
Jessica E. Salvatore
Arpana Agrawal
ResearchOpen Access21 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-12
Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy

Brooke Sadler
Gabe Haller
Alison Goate
ResearchOpen Access28 Mar 2014
Scientific Reports

Volume: 4, P: 1-8
Translating genome-wide association findings into new therapeutics for psychiatry

The Psychiatric Genomics Consortium is aiming to analyze data from >1 million individuals. This is already leading to hundreds of new genetic findings across psychiatric disorders with the potential to restart largely stalled psychiatric drug development pipelines. This paper outlines key questions and plans to translate findings into new therapeutics.

Gerome Breen
Qingqin Li
Howard J Edenberg
Comments & Opinion26 Oct 2016
Nature Neuroscience

Volume: 19, P: 1392-1396
COVID-19 pandemic stressors are associated with reported increases in frequency of drunkenness among individuals with a history of alcohol use disorder

Jacquelyn L. Meyers
Vivia V. McCutcheon
Bernice Porjesz
ResearchOpen Access06 Oct 2023
Translational Psychiatry

Volume: 13, P: 1-10
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

A quantitative high-throughput screen identified an inhibitor of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine synthesis. This inhibitor limits one-carbon unit availability for nucleotide synthesis.

Michael E Pacold
Kyle R Brimacombe
David M Sabatini
Research25 Apr 2016
Nature Chemical Biology

Volume: 12, P: 452-458
Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders

Stacey Saenz de Viteri
Jian Zhang
Jacquelyn L. Meyers
ResearchOpen Access21 Jun 2023
Molecular Psychiatry

Volume: 28, P: 3391-3396
Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts

Peter B. Barr
Morgan N. Driver
Danielle M. Dick
Research04 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4633-4641
Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans

Dongbing Lai
Tae-Hwi Schwantes-An
Tatiana Foroud
ResearchOpen Access05 Jul 2022
Translational Psychiatry

Volume: 12, P: 1-7
A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior

Jacquelyn L. Meyers
Jian Zhang
Bernice Porjesz
Research20 May 2020
Molecular Psychiatry

Volume: 26, P: 5040-5052
Genome-wide association study of stimulant dependence

Jiayi Cox
Richard Sherva
Lindsay A. Farrer
ResearchOpen Access29 Jun 2021
Translational Psychiatry

Volume: 11, P: 1-10
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

The Psychiatric GWAS Consortium Bipolar Disorder Working Group reports a large-scale genome-wide association study of 7,481 individuals with bipolar disorder with replication in 4,493 cases. The Consortium identifies a new susceptibility locus near ODZ4 and replicates a known association near CACNA1C for bipolar disorder.

Pamela Sklar
Stephan Ripke
Shaun M Purcell
Research18 Sept 2011
Nature Genetics

Volume: 43, P: 977-983
Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study

Sivan Kinreich
Jacquelyn L. Meyers
Bernice Porjesz
Research08 Oct 2019
Molecular Psychiatry

Volume: 26, P: 1133-1141
Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Na Cai
Brad Verhulst
Kenneth S. Kendler
Amendments and CorrectionsOpen Access28 Jan 2025
Molecular Psychiatry

Volume: 30, P: 1715
Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder

Fabiana L. Lopes
Kevin Zhu
Francis J. McMahon
ResearchOpen Access24 Aug 2020
Translational Psychiatry

Volume: 10, P: 1-7
Genetic nurture effects for alcohol use disorder

Nathaniel S. Thomas
Jessica E. Salvatore
Denise Scott
Research17 Oct 2022
Molecular Psychiatry

Volume: 28, P: 759-766
Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk

Peter B. Barr
Travis T. Mallard
Danielle M. Dick
ResearchOpen Access30 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-8
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Emma C. Johnson
Isabelle Austin-Zimmerman
Arpana Agrawal
ResearchOpen Access21 Jun 2024
Neuropsychopharmacology

Volume: 49, P: 1655-1665
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Genome-wide significant association between a ‘negative mood delusions’ dimension in bipolar disorder and genetic variation on chromosome 3q26.1

S Meier
M Mattheisen
M Rietschel
ResearchOpen Access25 Sept 2012
Translational Psychiatry

Volume: 2, P: e165
Correction to: Psychiatric genetics and the structure of psychopathology

Jordan W. Smoller
Ole A. Andreassen
Kenneth S. Kendler
Amendments and Corrections14 Mar 2018
Molecular Psychiatry

Volume: 24, P: 471
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

Dina Popova
Isabel Gameiro-Ros
Ronald P. Hart
Research07 Oct 2022
Molecular Psychiatry

Volume: 28, P: 746-758
Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach

Kaitlin E. Bountress
Shannon E. Cusack
Ananda B. Amstadter
ResearchOpen Access18 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry

J L Meyers
J Zhang
B Porjesz
Research10 Jan 2017
Molecular Psychiatry

Volume: 22, P: 1767-1775
Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Manav Kapoor
Jen-Chyong Wang
Alison Goate
ResearchOpen Access14 Feb 2019
Translational Psychiatry

Volume: 9, P: 1-11
Embryonic ethanol exposure alters expression of sox2 and other early transcripts in zebrafish, producing gastrulation defects

Swapnalee Sarmah
Rajneesh Srivastava
James A. Marrs
ResearchOpen Access03 Mar 2020
Scientific Reports

Volume: 10, P: 1-13

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