Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Hsuan-An Chen Clear advanced filters

  • Understanding the mechanisms driving PI3K isoform dependency in prostate cancer can help the design of future clinical trials. Here, the authors show that gain-of-function mutations in PIK3CA or PIK3CB can confer PI3K p110 isoform dependency and that the direct inhibition of AKT may be superior to PI3K inhibition in PTEN-deficient prostate cancers.

    • Ninghui Mao
    • Zeda Zhang
    • Brett S. Carver
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.

    • Direna Alonso-Curbelo
    • Yu-Jui Ho
    • Scott W. Lowe
    Research
    Nature
    Volume: 590, P: 642-648

  • Epigenomic data on chromatin accessibility and transcription factor occupancy can reveal enhancer landscapes in cancer. Here, the authors develop a computational strategy called PSIONIC (patient-specific inference of networks informed by chromatin) to model the impact of enhancers on transcriptional programs in gynecologic and basal breast cancers.

    • Hatice U. Osmanbeyoglu
    • Fumiko Shimizu
    • Christina S. Leslie
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12