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Nipah virus is a WHO priority pathogen, and there is currently no approved drug for clinical therapy. Here, the authors identified potent human neutralizing antibodies that block receptor binding and provide protection against NiV infection in vivo.

Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding ___domain as evidenced by Cryo-EM.

Traditional protein engineering methods are often slow and labor-intensive. Here, authors develop an automatic protein evolution platform enabled by a protein language model. Using this platform, they significantly improved the activity of a tRNA synthetase within ten days.

Applying neutralizing antibodies against SARS-CoV-2 to infected patients is a promising anti-viral treatment strategy. Here, Zhao et al. derive RBD-targeting monoclonal antibodies from a naïve human phage-displayed Fab library and show their  prophylactic and therapeutic potential in hACE2-transgenic mice.

Macrophages are considered a good candidate for cancer cytotherapy because of their phagocytotic capacity, enabling them to deliver cargo to tissues. Here authors engineer macrophages that are targeted to glypican-3-expressing tumour cells and equipped with drug-loaded exosomes and show therapeutic efficiency in a mouse model of hepatocellular cancer.

The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resource for the genetic improvement of wheat.

There are no approved interventions for Hendra or Nipah viruses. Here, the authors isolate a G glycoprotein-specific antibody with cross-neutralizing and in vivo protective activities, and structurally resolve its binding pattern to the G protein.

Understanding the mechanism of the formation and rupture of conductive filaments in HfO₂-based memristors is essential to solve the problem of scalability of the devices. Here, Zhang et al. visualize this process by tracking atomic-scale evolution of conductive filaments during resistive switching cycles.

Accurate end-to-end deep learning models for adsorption prediction in porous materials would help its discovery. Here, the authors present DeepSorption, a spatial atom interaction learning network to predict structure-adsorption from atomic coordinates and chemical element types.

The dual-cations electrochemical system was considered to be a promising strategy to facilitate sluggish diffusion kinetics. Here the authors prepare zinc-based alloy anode with three-dimensional interface, thus to improve the interfacial stability, achieve high-performing battery system in the aqueous electrolytes containing dual cations.

Nonlinear optical effects in 2D materials can be used for neuromorphic computing systems. Here, the authors introduced free-space optical computing within a bare MoS₂ array. Neural network and digital processing were demonstrated, showing fast speed, low energy consumption, and high signal-to-noise ratio.

Shengyue Wang and colleagues report the draft genome sequence and transcriptome analysis for Echinococcus granulosus, a parasitic helminth and cause of human hydatid disease. Their comparative genomic analysis identifies genes acquired by E. granulosus that are associated with host immune response, parasite survival and growth.

Neoadjuvant therapy is recommended for patients with locally advanced breast cancer. Here the authors report the results of a phase 2 clinical trial of oral neoadjuvant therapy with pyrotinib (pan-HER tyrosine kinase inhibitor), letrozole (aromatase inhibitor) and dalpiciclib (CDK4/6 inhibitor) in patients with treatment-naïve and stage II-III triple positive breast cancer.

The proactive approach to economically and safely extracting microalgae shows potential for efficiently controlling and preventing water blooms. A circular strategy mediated by a customized adsorber for electrostatic microalgae capture coupled with flexible magnetic collection demonstrates remarkable microalgae harvesting and recovery efficiency.

Dalpiciclib is a CDK4/6 inhibitor, recently approved for treatment in advanced breast cancer patients in China. Here, the authors report the results of a phase II trial investigating oral dalpiciclib (CDK4/6 inhibitor) and pyrotinib (pan-HER inhibitor) in patients with HER2-positive metastatic breast cancer.

Retrosynthesis aims to identify synthesis solutions for compounds in drug discovery. Here, the authors frame it as a molecular string editing task and utilize an iterative string editing model to provide high-quality and diverse solutions.

Deep learning can be used to predict molecular properties, but such methods usually need a large amount of data and are hard to generalize to different chemical spaces. To provide a useful primer for deep learning models models, Fang and colleagues use contrastive learning and a knowledge graph based on the Periodic Table and Wikipedia pages on chemical functional groups.

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

A bottom-up assessment of the net greenhouse gas emissions of the pulp and paper industries of 30 countries from 1961 to 2019 leads to country-specific strategies to achieve net zero by 2050.

Lithium selenium batteries are attractive energy storage systems, but they are hindered by low selenium reaction activity and rapid capacity fading. Herein, the authors report a selenium host with atomic cobalt electrocatalyst which exhibits superior performances in lithium-selenium batteries.

Here the authors characterize a monoclonal antibody from a COVID-19 convalescent patient that interferes with SARS-CoV-2 spike binding to ACE2 and has prophylactic and therapeutic activity in non-human primates. Antibody-dependent enhancement of infection is prevented by mutating the Fc region of the antibody.

Schistosoma mansoni and Schistosoma japonicum are the pathogenic agents that cause the tropical disease schistosomiasis. Here, and in an accompanying paper, the genomes of these two flatworms are sequenced and analysed. The results provide insights into the molecular architecture and host interactions of the flatworms, as well as avenues for future development of targeted interventions for schistosomiasis.

The mechanism for the enhanced piezoelectricity in (K,Na)NbO₃ based ceramics has not been fully understood. Here, the authors find that the dopants induced tetragonal phase and the accompanying high-density nanoscale heterostructures are responsible for the high dielectric and piezoelectric properties.

Current methods to reanalyze bulk RNA-seq at spatially resolved single-cell resolution have limitations. Here, the authors develop Bulk2Space, a spatial deconvolution algorithm using single-cell and spatial transcriptomics as references, providing new insights into spatial heterogeneity within bulk tissue.

The design of low-dimensional interface materials for perovskite solar cells is limited in the choice of the metal cation. By processing metal and ammonium halides together, Ye et al. expand the metal cation library for these interface materials.

The characterisation of the papillary thyroid carcinoma (PTC) tumour microenvironment remains crucial. Here, the authors perform single-cell RNA sequencing in 11 patients and identify potential opportunities for the use of immunotherapy and its combination with anti-angiogenic therapy in PTC.

A combination of structural and cell biology studies reveals the molecular mechanism how bozitinib inhibits c-Met and highlights its potential in the treatment of MET-amplified gastric cancer

An alternative approach to defect-trapped Pt single-sites on a semiconductor is reported. Here, protruding Pt sites inhibit charge recombination and cause a tip effect which enhances H₂ evolution yield rates with minimal co-catalyst loading.

Phase boundary engineering through chemical alloying and phase control is a traditional approach to enhancing piezoelectric properties. Here, the authors design a strategy in alkali niobate films, utilizing alkali vacancies without alloying to form nanopillars enclosed.

Superwetting membranes with tunable organic liquid (OL) repellency are highly desirable but remain a challenge. Here, the authors develop a nanoparticle-embedded reconfigurable membrane with switchable wetting modes for various OLs based on a self-defined interfacial physical parameter.

Successive fusion of yeast chromosomes is used to produce a single-chromosome strain that is viable, albeit with slightly reduced fitness.

The history of halogen-containing solid electrolytes is presented, and the advantages of halogen-chemistry for solid electrolytes related to crystal structures, migration pathways and ion transport mechanisms are summarized. Finally, the main challenges and future developments of halogen-containing solid electrolytes are discussed.

In a nested case-control study from the China Kadoorie Biobank, lowering blood low-density lipoprotein cholesterol levels confers lower risk for ischemic stroke but elevated risk for intracerebral hemorrhage, which was confirmed by genetic Mendelian randomization analyses.