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Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Excessive fibrosis triggered by bisphosphonates impairs fracture healing in osteoporotic bone. Here, the authors develop an injectable magnesium-alendronate MOF-based hydrogel adhesive and show it prevents fibrosis and enhances bone repair, improving healing strength in an osteoporotic rat model.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Disorder has emerged as a promising tool to manipulate properties of superconducting circuits. Here the authors demonstrate the use of disordered spinodal superconductor for fluxonium qubit fabrication and reveal an interesting correlation between the material disorder and the 1/f-type flux noise.

Toxic methylmercury in soil can accumulate in rice grains. Here, the authors use DNA stable-isotope probing and metagenomics to identify soil microbes and pathways potentially involved in methylmercury degradation.

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

Preliminary results from a phase 2a trial involving 71 patients suggest that a new agent, discovered and designed with artificial intelligence assistance, is safe and effective for the treatment of idiopathic pulmonary fibrosis.

The authors make a bimodal network polyacrylate dielectric elastomer featuring high driving frequency like silicones and thereby a high power density of 154 W kg⁻¹@20 MV m⁻¹, 200 Hz. Their rotary motor realizes a maximum rotating speed of 1245 rpm@ 19.6 MV m⁻¹.

PENSIEVE-AI is a drawing-based, digital cognitive test that can be self-administered in <5 min. It matches traditional tests in detecting cognitive impairment and dementia, offering promise for early detection in literacy-diverse populations.

Multiblock copolymers (MBCPs) comprising polyester and polyacrylate segments offer an efficient strategy for enhancing the performance of polyester and polyolefin blends but synthesis and structural modification of these MBCPs remains challenging. Here, the authors propose a method for synthesizing MBCPs via the switchable polymerization of epoxides, cyclic anhydrides, and acrylates using a dinuclear Co-complex.

A gap-free telomere-to-telomere genome assembly for a ram of Hu sheep uncovers genes and variants associated with domestication and selection for wool fineness.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Analysis of pre- and post-chemotherapy samples collected from 22 patients with high-risk neuroblastoma using single-nucleus RNA and ATAC sequencing and spatial omics characterizes therapy-related changes in cell composition and the tumor microenvironment.

3D printing has potential in designing personalised scaffolds, but minimally invasive implantation is still challenging. Here, the authors report the development of a polyurethane material with temperature triggered shape memory and water triggered deformation that allows for transcatheter delivery.

CYSLTR2 and P2RY6 are identified as endogenous ceramide receptors, and inhibition of these ameliorates atherosclerosis, particularly in chronic-kidney-disease-associated cardiovascular disease.

Tracing cellular changes in complex biological systems is challenging. Here, authors present a flexible framework that integrates multi-sample data with in-house algorithms to infer comparative and spatiotemporal cell-gene patterns, advancing understanding of cellular dynamics.

Covalent cross-linking can be used to improve the mechanical properties of fibers, but can be complicated to prepare and process. Here, the authors report fibers prepared with dynamic covalent bonds, which can reversibly dissociate to enable processing, while maintaining improved mechanical properties in the final material.

Under low-protein conditions, decrease of protein NUFIP1 is found to impair DNA damage response and induce necroptosis in the intestine, thereby contributing to intestinal inflammation in male mice with inflammatory bowel disease.

Piezoelectric materials are used as sensors or actuators in many devices. Here, the authors demonstrate that semiconducting ZnO particles embedded into a Bi_0.5Na_0.5TiO₃-based matrix improve its piezoelectric properties, promising an alternative to presently used lead-based materials.

The role of lactylation in non-histone proteins remains underexplored. Here, the authors investigate lactylation on ALDOA-K147 by proteomics, GCE, and biochemical assays, revealing its diverse regulatory effects on cellular processes, including metabolism, nuclear translocation and gene regulation.

Tan and colleagues conducted a single-cell multiomic analysis of T cell acute lymphoblastic leukemia and identified a treatment-resistant subpopulation of bone marrow progenitor-like blasts associated with poor outcomes.

Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.

Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Incorporating spin crossover motifs into mechanically interlocked molecules offers various switchable properties. Here, the authors report two Fe^II catenated metal-organic frameworks that exhibit spin dependent luminescence and dielectric switching.

Control of magnetization is at the core of many spintronic applications. Out-of-plane anti-damping magnon torque now enables low-power, deterministic switching of perpendicular magnetization at zero magnetic field.

Genetic studies of Chinese individuals have been performed, but mostly with short read sequencing, limiting the types of variants that can be identified. Here, the authors perform long read sequencing of 945 han Chinese individuals, finding structural variants under natural selection and those associated with human traits and evolutionary history.

Prenatal bisphenol A exposure is associated with an increased risk of ASD in boys through a mechanism involving aromatase suppression. These resulting ASD-related behaviors and brain abnormalities may be reversed through postnatal intervention with 10HDA in mice.

New study finds diazotroph-derived nitrogen is utilized by phytoplankton in upper euphotic zone, while below, it is used by nitrifiers. The newly identified pathways reveal the marine nitrogen cycle may be more interconnected than previously recognized.

This analysis provides a collection of sequencing datasets generated from long-read and short-read RNA sequencing, serving as a valuable resource for transcriptome profiling.

Structural characterization of protein complexes is challenging for low-input samples. Here, authors develop a SNAP-MS mass spectrometry workflow based on dissolvable hydrogel beads to enable efficient purification and native-MS-based analysis from biological samples.

Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.

A key feature of the evolutionary transformation of grass cell walls is the cross-linking of interwoven arabinoxylans via ferulate units. This study discovered an unexpected sucrose ferulate cycle that mediates the feruloylation of arabinoxylan.

The acidic oxygen reduction reaction (ORR) plays a crucial role in proton-exchange membrane fuel cells. Here, the authors develop a mesoporous amorphous-crystalline (a-c) heterojunction catalyst which promotes the protonation of *O intermediate via dynamic a-c interface electron redistribution.

The production of higher alcohols is very valuable because of their high volumetric energy density. Now, Sargent, Sinton and co-workers report the design of copper nanoparticles with tailored nanocavities that promote n-propanol formation by the coupling of C2 and C1 intermediates inside the cavity.

Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis.

Mechanically interlocked structures in polymer backbones can give interesting functionality, but can be challenging to prepare and control. Here, the authors report the development of polymers with a daisy chain unit in the backbone that are capable of shape memory behaviour.

Axially chiral compounds play an important role in areas such as asymmetric catalysis. Here, the authors report an organocatalytic asymmetric tyrosine click-like reaction, giving access to enantio enriched urazoles with restricted rotation around an N-C bond.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Here the authors identify distinct mechanisms by which ___domain-specific p53 mutations activate cancer cell growth via the epidermal growth factor receptor (EGFR). These mechanisms affect sensitivity to EGFR inhibitors, opening avenues for targeted therapy.

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

Steam treatment transforms inactive Pd₁/CeO₂ catalyst into a highly reactive one by forming a Ce₂O₃-Pd nanoparticle interface. This ___domain interface is created by the coordinated migration of Ce and Pd atoms on the atom trapped Pd₁/CeO₂.

The role of chromatin rewiring of regulatory elements in multiple myeloma (MM) remains poorly understood. Here, the authors identify a super-enhancer driven gene, PPP1R15B whose perturbation confers vulnerability in MM cells and suggest it as a therapeutic target.