This study reveals a novel role for the stress-response protein sirtuin 6 (SIRT6) in modulation of glucolipid metabolism disorders in the liver and pancreas under conditions of overnutrution and starvation. The authors show that SIRT6 regulates SREBP1c through the AMPKα-mTORC1 pathway, which and then affects glucolipid metabolic enzymes in an LXR-independent pathway.
- Che Bian
- Haibo Zhang
- Huiwen Ren
