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Neuronal impact of patient-specific aberrant NRXN1α splicing

Transcriptome and functional studies in human iPSC-derived neurons suggest that the phenotypic effects of NRXN1 deletions can occur through reduction in wild-type NRXN1α isoform levels and expression of mutant NRXN1α isoforms.

Erin Flaherty
Shijia Zhu
Kristen J. Brennand
Research29 Nov 2019
Nature Genetics

Volume: 51, P: 1679-1690
Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from patients with childhood-onset schizophrenia.

Gabriel E. Hoffman
Brigham J. Hartley
Kristen J. Brennand
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-15
Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells

Inkyu S Lee
Claudia M B Carvalho
Kristen J Brennand
ResearchOpen Access24 Jun 2015
npj Schizophrenia

Volume: 1, P: 1-5

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