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Genome-wide association study identifies five loci associated with lung function

Martin Tobin and colleagues present genome-wide association studies for pulmonary function as part of the SpiroMeta consortium.

Emmanouela Repapi
Ian Sayers
Martin D Tobin
Research13 Dec 2009
Nature Genetics

Volume: 42, P: 36-44
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Louise Wain, Ian Hall, Martin Tobin and colleagues report genome-wide association analyses of lung function, identifying 43 new signals associated with one or more lung function traits. A genetic risk score derived from these results was significantly associated with risk for chronic obstructive pulmonary disease in independent populations.

Louise V Wain
Nick Shrine
Martin D Tobin
Research06 Feb 2017
Nature Genetics

Volume: 49, P: 416-425
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

A genome-wide association study in more than 400,000 individuals identifies 139 new signals for lung function. These variants can predict chronic obstructive pulmonary disease in independent, transancestral cohorts.

Nick Shrine
Anna L. Guyatt
Louise V. Wain
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 481-493
Genome-wide association analysis identifies six new loci associated with forced vital capacity

Stephanie London, Martin Tobin and colleagues report meta-analyses of genome-wide association studies for forced vital capacity (FVC), a spirometric measure of pulmonary function that reflects lung volume. They identify six regions newly associated with FVC and demonstrate that candidate genes at these loci are expressed in lung tissue and primary lung cells.

Daan W Loth
María Soler Artigas
Stephanie J London
Research15 Jun 2014
Nature Genetics

Volume: 46, P: 669-677
Genetics of chronic respiratory disease

In this Review, Sayers et al. summarize findings from recent large-scale genetic epidemiology studies on the genetic underpinnings of chronic respiratory diseases. Furthermore, they outline how insights gained from such studies can improve treatment approaches.

Ian Sayers
Catherine John
Ian P. Hall
Reviews06 Mar 2024
Nature Reviews Genetics

Volume: 25, P: 534-547
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Martin Tobin and colleagues report a meta-analysis of 23 genome-wide association studies for pulmonary function. They identify 16 loci newly associated with variation in two cross-sectional measures of lung function, used to define airway obstruction and to grade the severity of obstruction.

María Soler Artigas
Daan W Loth
Martin D Tobin
Research25 Sept 2011
Nature Genetics

Volume: 43, P: 1082-1090
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine
Anna L. Guyatt
Louise V. Wain
Amendments and Corrections19 Apr 2024
Nature Genetics

Volume: 56, P: 1032-1033
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Genetic and environmental factors impact on lung function, important in the diagnosis of pulmonary diseases. Here the authors use imputation of genotypes to the 1000 Genomes Project reference panel to identify novel, low frequency variants associated with lung function.

María Soler Artigas
Louise V. Wain
Martin D. Tobin
ResearchOpen Access04 Dec 2015
Nature Communications

Volume: 6, P: 1-12
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Multi-ancestry genome-wide association analyses and systematic variant-to-gene mapping strategies implicate new genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

Nick Shrine
Abril G. Izquierdo
Martin D. Tobin
ResearchOpen Access13 Mar 2023
Nature Genetics

Volume: 55, P: 410-422
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine
Anna L. Guyatt
Louise V. Wain
Amendments and Corrections20 May 2019
Nature Genetics

Volume: 51, P: 1067
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Nick Shrine
Abril G. Izquierdo
Martin D. Tobin
Amendments and CorrectionsOpen Access25 Sept 2023
Nature Genetics

Volume: 55, P: 1778-1779
A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist

Ian R Wilkinson
Eric Ferrandis
Richard J Ross
Research26 Aug 2007
Nature Medicine

Volume: 13, P: 1108-1113
A long-acting GH receptor antagonist through fusion to GH binding protein

Ian R. Wilkinson
Sarbendra L. Pradhananga
Richard J. Ross
ResearchOpen Access12 Oct 2016
Scientific Reports

Volume: 6, P: 1-7
Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC₄ synthase gene

I Sayers
A P Sampson
S T Holgate
Research31 Jul 2003
European Journal of Human Genetics

Volume: 11, P: 619-622

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