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Showing 1–8 of 8 results
Advanced filters: Author: Ilias Angelidis Clear advanced filters

  • Aging impacts lung functionality and makes it more susceptible to chronic diseases. Combining proteomics and single cell transcriptomics, the authors chart molecular and cellular changes in the aging mouse lung, discover aging hallmarks, and predict the cellular sources of regulated proteins.

    • Ilias Angelidis
    • Lukas M. Simon
    • Herbert B. Schiller
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.

    • Gizem Günes Günsel
    • Thomas M. Conlon
    • Ali Önder Yildirim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Adipocyte plasticity during injury repair is debated. Here, the authors find that injury causes temporary adipocyte migration, but without lineage conversion to myofibroblasts. Distinct migration patterns, transcriptomics and ECM depositions indicate that adipocytes, unlike fibroblasts, do not contribute to fibrotic scars.

    • Shruthi Kalgudde Gopal
    • Ruoxuan Dai
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and persists in human lung fibrosis.

    • Maximilian Strunz
    • Lukas M. Simon
    • Herbert B. Schiller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559